Protein Alignment Ork1 and KCNA2

DIOPT Version :10

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_004965.1
• Gene: KCNA2 / 3737
• HGNCID: 6220
• Length: 499
• Species: Homo sapiens
• Alignment Length: 172
• Identity: 32/172 - (18%)
• Similarity: 64/172 - (37%)
• Gaps: 64/172 - (37%)

  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISD 71
            :|:...:|..::|.:|:|:         :.|::|::|.
Human   330 LLIFFLFIGVILFSSAVYF---------AEADERESQF--------------------------- 358

  Fly    72 YCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI-----P 131
                     |:..|         ||::|....:|||||::.|||..|:::....::.|:     |
Human   359 ---------PSIPD---------AFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALP 405

  Fly   132 VNGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVP--PQL 171
            | .::.:....::.|..|.  ....:|...|....:|  |.|
Human   406 V-PVIVSNFNYFYHRETEG--EEQAQYLQVTSCPKIPSSPDL 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	16/65 (25%)
		Ion_trans_2	185..266	CDD:462301
KCNA2	NP_004965.1	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:453885
		Ion_trans	162..420	CDD:459842	25/144 (17%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		4/4 (100%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499