DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and Kcnk5

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001034605.1	Gene:	Kcnk5 / 364241	RGDID:	1564985	Length:	503	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	131/533 - (24%)
Similarity:	216/533 - (40%)	Gaps:	99/533 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NRWILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQR 68
            :|..||....|.||..||||:..:|....|    |.:|.......:||:|....:....|:|||.
  Rat     3 DRGPLLTSAIIFYLAIGAAIFEVLEEPHWK----EAKKNYYTQKLHLLKEFPCLSQEGLDKILQV 63

  Fly    69 ISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVN 133
            :||..|:.|.:  |.:.|...|.:.:|..||.||.:|:||||::|.|.|||:..:.|.:.|:|:.
  Rat    64 VSDAADQGVAI--TGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLC 126

  Fly   134 GILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLLLPSWVFTY 198
            ....:.||::||       .|.|:.........|..:...||...|.::.|:.:.|::|.:||..
  Rat   127 LTWISALGKFFG-------GRAKRLGQFLTRRGVSLRKAQITCTAIFIVWGVLVHLVIPPFVFMV 184

  Fly   199 FENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTF 263
            .|.|.|...||||::|.:||||||:|.  |.|..   ..:..:|:.||.:|....|.:|.:.:.:
  Rat   185 TEEWNYIEGLYYSFITISTIGFGDFVA--GVNPS---ANYHALYRYFVELWIYLGLAWLSLFVNW 244

  Fly   264 -------ITRGLQSKKLAYLEQQLSS--NLKATQNRIWSGVTKDV---GYLRRMLNELYILKVKF 316
                   :.:.::.::....|...||  :.||.| ...|..:|||   .:|.:. .|.|...:|
  Rat   245 KVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQ-MAGSTASKDVNIFSFLSKK-EETYNDLIK- 306

  Fly   317 CRKGNRKKPKNKAKTEQKKKSSRYIAY-------TLPRSNSCPDLSMYRVEPAPIPSRKRAFSVC 374
              :..:|..|.....|:.......:..       ::|.|          :.|..:.|:.|..|:
  Rat   307 --QIGKKAMKTSGGGERVPGPGHGLGAQGGDGLPSIPAS----------LAPLVVYSKNRVPSL- 358

  Fly   375 ADMVAAQREAGMV----------------HANSDTELSKLDR---------------------EK 402
            .::....|..|.|                :..|:..:::|||                     ..
  Rat   359 EEVSQTLRNKGHVSRPLGEDAAAQTPKEGYPTSEVFINQLDRISEEGEPWEALDYHPLIFQNANI 423

  Fly   403 TFETAEAYRQTTDLLAKVVNALATVK----PPPAEQEDAALYGGYHGFSDSQILASEWSFST--- 460
            |||..|......:.....|....|.|    |.|..:..::..|.:....:|...::|...|.
  Rat   424 TFENEETGLSDEETSKSSVEDNLTSKEQPQPGPMTEVPSSSTGEFPSSDESTFTSTESELSVPYE 488

  Fly   461 --VNEFTSPRRPR 471
              :||:.....||
  Rat   489 KLMNEYNKADSPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	21/53 (40%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	27/90 (30%)
Kcnk5	NP_001034605.1	Ion_trans_2	<81..137	CDD:285168	21/55 (38%)
Kcnk5	NP_001034605.1	Ion_trans_2	171..243	CDD:285168	27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349062
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm45417
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.840