DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and twk-43

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_872137.2	Gene:	twk-43 / 3565024	WormBaseID:	WBGene00006693	Length:	597	Species:	Caenorhabditis elegans

Alignment Length:	544	Identity:	111/544 - (20%)
Similarity:	198/544 - (36%)	Gaps:	172/544 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFA 99
            |:|.::::.:|:.::::.: |.:..||.|.||                               |.
Worm   141 SKAPEQQSAVALKKFVIVD-GFEQWTTTDAIL-------------------------------FC 173

  Fly   100 FTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFG-------RTFEAIYRRYKK 157
            |||.:|:||||::|.:|.||:.:|.|..||||...:..|.:|::..       |.|..:.|:.||
Worm   174 FTVITTIGYGNVAPQSFWGRVFVIIYGTIGIPTAMMAIANVGKFLATLLKSWTRPFLLLCRKMKK 238

  Fly   158 YKMSTDM--HYVPPQLGLI------------------------------TTVVIALIPGIALFLL 190
            .....|.  :.:.....|:                              .|..|.|.....::::
Worm   239 RMQKKDQNGNEIKETQRLMESSKKKAKKIEDDISSHEDEEAEEEVEESDVTETIVLFVAFLVYII 303

  Fly   191 LPSWVFTYF-ENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSL 254
            ..|.:.:|: |...:.:::|:::||.||||.||.||     |..:              |...:|
Worm   304 AGSLLMSYYEEGMTFGLAIYFNFVTLTTIGLGDLVP-----QSTD--------------WLFVTL 349

  Fly   255 GYLVMIMTFITRGLQ-----SKKLAYLEQQLSSNLKATQN-RIWSG--------VTKDVG-YLRR 304
            .|..:.:...|..::     .|||.|..::|.:    .|| :||.|        :.|::| .|..
Worm   350 VYCAIGLALTTIAIEIAADTLKKLHYFGRKLDN----VQNVQIWFGGQKLSMKALVKNLGDQLNV 410

  Fly   305 MLNELYILKV-KF-------------CRKGNRKKPKNKAKTEQKKKSSRYI----AYTLPRSNSC 351
            .:.||..|.: ||             ..:.:|....:......:..|..|:    ..||..:.||
Worm   411 PVEELENLDLAKFVDDAIKVEAGELTTLRNDRAWMNSNYWRAIESGSMHYVDDDDLVTLQSNLSC 475

  Fly   352 PDLSMYRVEPAPIPSRKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDL 416
            ....|.    ..:|..:   |..:.|:....|.....::.:.:|..::.|  :||    .|..|:
Worm   476 GSQQML----IRVPYSR---STDSRMITVNHEPLTETSDENFKLHSVNEE--YET----EQFPDI 527

  Fly   417 LAKVVNALATVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTSPRRPRARACSDFNLE 481
            .|::::     ||..::.|...        ..||.:..:              ...:|.:|.|.|
Worm   528 EAEIID-----KPEVSQNEGIR--------KSSQCIELQ--------------KLLKALNDLNNE 565

  Fly   482 A----PRWQSERPLRSSHNEWTWS 501
            .    .||..|...|....:..||
Worm   566 VVSQDGRWSEEARRRYLEYQRIWS 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	21/53 (40%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	19/84 (23%)
twk-43	NP_872137.2	Ion_trans_2	<162..218	CDD:285168	26/86 (30%)
twk-43	NP_872137.2	Ion_trans_2	298..372	CDD:285168	19/92 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010