Protein Alignment Ork1 and Kcnk18

DIOPT Version :10

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_997144.1
• Gene: Kcnk18 / 332396
• MGIID: 2685627
• Length: 394
• Species: Mus musculus
• Alignment Length: 390
• Identity: 81/390 - (20%)
• Similarity: 131/390 - (33%)
• Gaps: 159/390 - (40%)

  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDK------NTTTQDEI 65
            :..|...::|.:.|||::..:|...:  ..||:       |..|.:.|.|.      |.|..:..
Mouse    35 LCFLCCLVTYALVGAALFSAVEGRPD--PEAEE-------NPELKKFLDDLCNILKCNLTVVEGS 90

  Fly    66 LQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGI 130
            .:.:   |:....|.|.:...|..|:|..|.||..||.||||||::.|.|..|:.:.:.|::.||
Mouse    91 RKNL---CEHLQHLKPQWLKAPQDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGI 152

  Fly   131 PVNGILFAGLGEYFG-------------------------------------------------- 145
            |:..::...:|:...
Mouse   153 PLMFLVLTDIGDILATILSRAYSRFQALLCLPHDIFKWRSLPLCRKQPDSKPVEEAIPQIVIDAG 217

  Fly   146 --------------------RTFEAIYRRYKKYKMSTDMHYVPPQ-------------LGLITTV 177
                                ..||.:..|.||.|:.      ||.             ||.::..
Mouse   218 VDELLNPQPSKDPPSPSCNVELFERLVAREKKNKLQ------PPTRPVERSNSCPELVLGRLSCS 276

  Fly   178 VIA--------------LIPGIALFL---------LLPSWVFTY-FENWPYSISLYYSYVTTTTI 218
            :::              .:|.|||.:         :||.|.... ||:     :.|:.:||.|||
Mouse   277 ILSNLDEVGQQVERLDIPLPVIALVVFAYISCAAAILPFWETELGFED-----AFYFCFVTLTTI 336

  Fly   219 GFGDYV---PTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMIMTFITRGLQSKKLAYLEQQL 280
            ||||.|   |.|           |:.:.|::||.         |.:.||...|...:|.:..:.|
Mouse   337 GFGDIVLVHPHF-----------FLFFSIYIIVG---------MEILFIAFKLMQNRLLHTYKTL 381

  Fly   281  280
            Mouse   382  381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	22/60 (37%)
		Ion_trans_2	185..266	CDD:462301	28/93 (30%)
Kcnk18	NP_997144.1	Ion_trans_2	105..166	CDD:462301	22/60 (37%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	127..132		4/4 (100%)
		Interaction with calcineurin. /evidence=ECO:0000269|PubMed:16569637	210..215		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000269|PubMed:18397886	261..266		0/4 (0%)
		Ion_trans_2	297..374	CDD:462301	29/101 (29%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q7Z418	335..340		4/4 (100%)