Protein Alignment Ork1 and twk-13

DIOPT Version :10

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_001122984.1
• Gene: twk-13 / 192077
• WormBaseID: WBGene00006668
• Length: 625
• Species: Caenorhabditis elegans
• Alignment Length: 548
• Identity: 107/548 - (19%)
• Similarity: 179/548 - (32%)
• Gaps: 190/548 - (34%)

  Fly     5 RWIL-------LLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELG--DKNTT 60
            ||..       |::..|.|.:.||..::|.|...|:..|.|..:....:...::::|.  ..|.|
 Worm   108 RWFRLALPHFGLVLLSIGYTLIGALCFHHYEKPYEQQLRNETSRRIGELKNRVMDQLWRMSNNGT 172

  Fly    61 T-----------QDEILQRIS-DYCDKPVTLPPT-YDDTPYTWTFYHAFFFAFTVCSTVGYGNIS 112
            .           .||:::.:. ||....:|.... |.|.|..|:|..:.||::|..:|:|||:|.
 Worm   173 AYSTWRQTANDGMDELIRDVFWDYTRNYMTPDDVIYGDGPIKWSFMSSIFFSWTAITTIGYGHIV 237

  Fly   113 PTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIYRRY------------KKYK-----M 160
            |.|..||:.:|.|:::|||:..:..|.:|.:.......::..|            |..|     :
 Worm   238 PRTDEGRVAIIFYALLGIPLILVTIADIGRFLATYIIKLHHGYMAVMSFVTNSCLKCIKWACCWI 302

  Fly   161 STDMHYVP-PQLGLI-------------TTVVIALIPG--------------------------- 184
            .....::| |.|.|:             |....|...|
 Worm   303 RLPRRHIPMPTLELLQRTQKLYPNNNNPTVAATAASAGGGTGRRKKQQRDNVSDAGTFDNISEIN 367

  Fly   185 -----------------------------IALFLLL--------PSWVFTYFENWPYSISLYYSY 212
                                         ..||:||        .:::..::|.|.:..:.|:.:
 Worm   368 DGSEGGENENEGEEEEQIQFDPSNHEKRVSVLFILLIMLGYVAGGAYIVRWWEEWTFFEAFYFCF 432

  Fly   213 VTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLV--MIMTFITRGLQSKKLAY 275
            ||.|||||||.||   ||                :.|...:|.|:|  :|:|.:...|
 Worm   433 VTVTTIGFGDIVP---AN----------------VDWLPATLAYIVFGLIITTMCIDL------- 471

  Fly   276 LEQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYIL-------------KVKFCRKGNRKKPKN 327
                           :.|...:|:.:..|.|...::.             .|.|.:|......:.
 Worm   472 ---------------VGSEYIRDIHFYGRSLGRQFMTIGGKVVHLGEVFGYVAFLQKNYGLTAEQ 521

  Fly   328 KAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEPAPIP--------SRKRAFSVCADMVAAQREA 384
            ..|..|..:  .|:...|..... |||:.....|...|        ...|..|..:|.|....|
 Worm   522 LTKLSQLPE--EYLLDCLINGRQ-PDLNWIGGRPYVPPDIYYFKWIEHPRTLSFASDRVLQSME- 582

  Fly   385 GMVHANSDTELSKLDREKTFETAEAYRQ 412
                 :.|...|:....:|....|.|::
 Worm   583 -----SLDLNTSRCSTARTLTPREYYQK 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	24/60 (40%)
		Ion_trans_2	185..266	CDD:462301	26/90 (29%)
twk-13	NP_001122984.1	Ion_trans_2	<214..269	CDD:462301	21/54 (39%)
		Ion_trans_2	401..478	CDD:462301	26/117 (22%)