DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and twk-12

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_505731.3	Gene:	twk-12 / 192074	WormBaseID:	WBGene00006667	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	707	Identity:	145/707 - (20%)
Similarity:	247/707 - (34%)	Gaps:	212/707 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RWILLLI----FY-----ISYLMFGAAIY--YH--------------------------IEHGEE 32
            :|...||    :|     |:|..|||.::  |.                          ||..::
Worm     8 QWFCNLIRLRSYYKFLLLIAYTAFGAWLFRTYELQADIKRRSVFGNTTNLVRRQLAERWIEMHKD 72

  Fly    33 KISRAEQ----RKAQIAINEYLLEELGDKNTTTQDEILQRISDYCDKPVTLPPTYDDTPYTWTFY 93
            .:.|.:.    |:|..|: |:||:||             .:||:      :....::||:|||
Worm    73 AVLRNDSALRFRRAAEAV-EWLLDEL-------------NLSDH------IRDLSEETPWTWT-- 115

  Fly    94 HAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIYRRYKKY 158
            .|.|:|..:.:|:|||..:..|..||:..|.|::.|||...:....:|:...:..:..|::.::.
Worm   116 GAMFYAGQLYTTIGYGYPTTKTDEGRICTIFYALFGIPCFLMYLKSIGKTLSKKMKKYYKKLRRS 180

  Fly   159 KMSTDMHYVPPQLGLITTVVIALIPG------------------IALFLLLPSWV------FTYF 199
            ::...         |:.|.|.|:..|                  ||:.:|: .|:      |..:
Worm   181 RVGRI---------LLPTRVTAMKDGFEDPEAAEERKKKPFPIPIAIIMLI-IWICFSASMFCIW 235

  Fly   200 EN-WPYSISLYYSYVTTTTIGFGDYV---PTFGANQPKEFGGWFVVYQIFVIVWFIFSLGYLVMI 260
            |: |.:|.::|:..|:.:|:|.||.:   |..               .:|..:..:..|..|.|.
Worm   236 EDTWVFSSAVYFFIVSISTVGLGDMLFRTPDM---------------MVFNFLLILVGLALLSMC 285

  Fly   261 MTFITRGLQSKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLNELYILKVKFCRKGNRKKP 325
            ...||    .:...:.:::...::|..|...:....||     ..:.|...|.::..  .|..:.
Worm   286 FELIT----DRVAKWKQKRFDEHIKKVQKMAFQVFEKD-----PFIEEAPPLGIRMA--PNLMQI 339

  Fly   326 KNKAKTEQK-------------KKSSRYIAYTLPRSNSCPDLSMYRVEPAPIPS----RKRAFSV 373
            .....:|:|             |.:...|...|..|:...| |...:|....|.    ......|
Worm   340 AATHVSEEKRGFFAEFKDWFAGKVTDNVIQSKLEDSDDESD-SEEALEEFDSPQIATVTANDLIV 403

  Fly   374 CADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPPAEQEDAA 438
            |::..|.:|.:...:|.||  :|.|...|.. ....|.|..|.    :.|:...||...:. |:.
Worm   404 CSNGAATRRVSKQSYALSD--ISNLSNSKIL-PGNNYGQLLDR----IKAMEKFKPKKNDL-DSR 460

  Fly   439 LYGGYHGFSDSQILASEWSFSTVNEFTSPRRPRARACSDFNLEAPRWQSERPLRSSHNEWTWSGD 503
            ::.   .|.:::.||.      :.|.|..|.....:|.. :|.....|...|
Worm   461 MFA---KFLENKKLAK------ILEQTELRELATVSCQT-DLSGLVVQRRNP------------- 502

  Fly   504 NQQIQEAFNQRYKGQQRANG--AANSTMVHLEPDALEEQLKKQSPGAGRVKKFSMPDGLRRLFPF 566
                        ||:....|  ::.|||..|.|:      |..:|....|..|:..| |:  |.:
Worm   503 ------------KGRHARIGSCSSQSTMSTLLPN------KMHAPDEDSVMSFTFGD-LK--FDY 546

  Fly   567 QKKRPSQDLERKLSVVSVPEGVISQQARSPLDY-YSNTVTAASSQSYLRNGRGPPPP 622
             |..|..|           |..|.:...|..|: ...||.........|.|..||||
Worm   547 -KTEPFID-----------EYYIRESNHSIFDFDEDETVRIPQKMLISRPGMPPPPP 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	18/53 (34%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	21/93 (23%)
twk-12	NP_505731.3	Ion_trans_2	92..167	CDD:285168	27/95 (28%)
twk-12	NP_505731.3	Ion_trans_2	226..>272	CDD:285168	12/60 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910