Protein Alignment Ork1 and twk-1

DIOPT Version :10

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_001293466.1
• Gene: twk-1 / 192072
• WormBaseID: WBGene00006656
• Length: 451
• Species: Caenorhabditis elegans
• Alignment Length: 512
• Identity: 101/512 - (19%)
• Similarity: 187/512 - (36%)
• Gaps: 183/512 - (35%)

  Fly     1 MSPNRWILLL-IFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDE 64
            |..:.::|:| :..|.|::||..::                            :|...:|..:..
 Worm    65 MFASTYVLILNVALILYVLFGCQVF----------------------------DLRHSSTNNEAS 101

  Fly    65 ILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIG 129
            .|.|.                           .|..|..||:|||||:|....|::|.|.|.|.|
 Worm   102 FLDRA---------------------------LFCITTISTIGYGNIAPFDDRGKVICILYCVAG 139

  Fly   130 IPV-------NGILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIA--LIPGI 185
            ||:       |.:|...:.....|::.:.......::..|            :.:::|  ...|.
 Worm   140 IPLFFMTVATNSVLVVDICNIVHRSYSSQNVENSGFRWYT------------SAILLAAHCFIGA 192

  Fly   186 ALFLLLPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWF 250
            .:|.|   |:    :...:..:.|:|:::.||||:|||.||     |:   |.|.    ::||..
 Worm   193 LIFSL---WI----DQLDFLDAFYFSFISITTIGYGDYSPT-----PE---GLFQ----YIIVTV 238

  Fly   251 IFSLGYLVMIMTF--ITRGLQSKKLAYLEQQLSSNLKATQNRIWSG----VTKDV---------- 299
            ....|...|::.|  :.:|:.  .:.|..:::|.:.:|   .||.|    ..||:
 Worm   239 YLCTGVATMLLFFASLQKGIM--WIHYYGRKVSDSEEA---EIWFGGQMMTVKDLVTLVAEKFGS 298

  Fly   300 --GYLRRMLNEL-YILKVKFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEP 361
              ..||.:|::| .||:|. |:         :|:.:..::..|.:       |:...||
 Worm   299 TPEKLREVLHDLDKILEVA-CK---------QAEEDDDEEDWRSV-------NNSEALS------ 340

  Fly   362 APIPSRKRAF-SVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALA 425
            .|.|.:|..| |..:|....|   ..:|:.:.|....:.::            |:|   .:.||.
 Worm   341 PPAPRKKTVFLSGSSDGDDCQ---ATIHSFTSTNQRSIPKD------------TEL---AILALG 387

  Fly   426 TVKPPPAEQEDAALYGGYHGFSDSQILASEWSFSTVNEFTSPRRPRARACSDFNLEA 482
            |::....:.....::|.:|                     .|:.|.::..||.|:|:
 Worm   388 TIQHHLRKPSVRGIHGHHH---------------------HPKIPFSKPASDSNIES 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	20/67 (30%)
		Ion_trans_2	185..266	CDD:462301	22/82 (27%)
twk-1	NP_001293466.1	Ion_trans_2	76..149	CDD:462301	26/127 (20%)
		Ion_trans_2	182..256	CDD:462301	24/92 (26%)