DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and twk-2

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001350984.1	Gene:	twk-2 / 188452	WormBaseID:	WBGene00006657	Length:	1519	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	145/754 - (19%)
Similarity:	262/754 - (34%)	Gaps:	224/754 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEEL-GDKNTTTQDEILQRIS 70
            |:|::....|...||.|:|.:|...|...:...||....:...|:.:: .::....:::|.:.:.
Worm    38 IVLVVCVCIYATIGAWIFYTLESPNEDRLKETGRKTIAEMRSNLIYKINNNEKEVWKEDIEKELM 102

  Fly    71 DYCDKPVTL------------------PPTYDDTPYT------------------------WTFY 93
            .|.:|....                  ..:|::...|                        ||..
Worm   103 LYSEKLYKAFKEQYVRYSDVRTIGFEGRSSYEEADETGGDSERKRRHRHGNKRGDRGSEKMWTTS 167

  Fly    94 HAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFAGLGEYFGRTFEAIYRR---- 154
            .|.|||.|..:|:|||||.|.|..||:..:.:::.|.|:..|....||::.......:|:.
Worm   168 SALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLSECTIWLYKHMRKG 232

  Fly   155 -------YKKYK---------------------MSTDMHYVP----PQLGLITTVVIALIPGIAL 187
                   :|:::                     :..||..:.    |.|.:.|.:::.:..|..|
Worm   233 SARLDSAWKRFRGLEDSISDDLESASKNQDSSILDMDMDEIDKSEVPVLMVFTIILLYIAFGGIL 297

  Fly   188 FLLLPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFIF 252
            |.:|        |:|.|..:.|||:::.|||||||.||        |...:..:..|::
Worm   298 FSIL--------EDWSYMDAFYYSFISLTTIGFGDIVP--------ENHDYIAIMLIYL------ 340

  Fly   253 SLGYLVMIMTFITRGLQ-SKKLAYLEQ--------QLSSNLKATQNRIWSGVTKDVGYLRRMLNE 308
            .:|..|..|.....|:| .:|:.|..:        |.....:..:.|:..|..:::  ||:
Worm   341 GVGLSVTTMCIDLAGIQYIQKIHYFGRKFQGTDLLQYLKKKRMLERRLAMGQGEEI--LRK---- 399

  Fly   309 LYILKV-KFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEPAPIPSRKR--- 369
             |:..| ||.|:..:.:.|.:.:.....:|..:            |.||.|::.:....:.|
Worm   400 -YVHAVEKFEREQEQLQQKMEEEDPPSIESKGF------------DNSMMRIDDSLSAFQLRFYD 451

  Fly   370 ------AFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTT-DLLAKVVNALATV 427
                  .||.....|.:.:.:...|:::        |.::|...:..|..: |.....::...::
Worm   452 TYDEEDLFSPTIHSVRSFQPSVWSHSSA--------RSQSFCRFQRNRGASWDESGPSLSEHCSL 508

  Fly   428 KPPPAEQEDAALYGGYHGFSDSQI-----------LASEWSFS---------------------- 459
            ...|:.....|.:..||..:.|.|           :||..||.
Worm   509 STEPSVHIRQAYWDNYHSPTPSVISFLHRHLYSPSIASSISFDYDCLAKDAKSARRSNSCPPIEI 573

  Fly   460 ----TVNEFTSPRRP-RARACSDFN----LEAPRWQSERPLRSSHNEWTWSGDNQQIQEAFNQ-- 513
                ..|..:||||| .||..|...    :.:....:..||.....|.....:...|.:||:.
Worm   574 PSPPPSNSVSSPRRPLSARTGSTIRTKHAIASEPIYTAAPLSFRLPEPFMLSNLAAICDAFDDAD 638

  Fly   514 --------RYKGQQRA-------NGAANSTMVHLEPDALEEQLKKQSPGAGRVKKFSMPDGLRRL 563
                    .::..|.|       :|.:....:|.:||.|.     ..|....|.|.|:
Worm   639 ACNNLVFGAFRESQLAANHYDSTDGFSGKVQLHPQPDILH-----PPPPPPYVPKLSL------- 691

  Fly   564 FPFQKKRPSQDLERKLSVVSVPEGVISQQARSPLDYYSN 602
               ..||.|...|.|:|  :.||.|:.::.:..:....|
Worm   692 ---SPKRLSVIDENKIS--TSPEPVLKRKNKERIARQQN 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	22/53 (42%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	24/83 (29%)
twk-2	NP_001350984.1	Ion_trans_2	<164..220	CDD:311712	22/55 (40%)
twk-2	NP_001350984.1	Ion_trans_2	285..360	CDD:311712	27/96 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910