DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ork1 and twk-24

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_001367093.1	Gene:	twk-24 / 179682	WormBaseID:	WBGene00006677	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	520	Identity:	103/520 - (19%)
Similarity:	184/520 - (35%)	Gaps:	159/520 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RWILLLIFYISYLMFGAAIYYHIEHGEEK---ISRAEQRKAQIAINEYLLEELGDKNTTTQDEIL 66
            |.|..|:...|:.:||..|:..||.|.|.   |.:.|..|           ::.::....|:::.
Worm   116 RHIAWLVVLFSFSLFGGVIFSAIEGGYETTQLIKKFEHEK-----------DVYERRKIYQEQLF 169

  Fly    67 QRISD-----------------------------YCDK-PVTL-PPTYDDTPYTWTFYHAFFFAF 100
            ||:.:                             |..| .||: .|...:|  .|..:...:::.
Worm   170 QRLREIEHDNTNPRGRNSSREHFKLEQSRHALEWYEQKMGVTIEEPQMRET--KWNLWGGVYYSA 232

  Fly   101 TVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVN-------GILFAGLGEY----FGRTF--EAIY 152
            ::.:|:||||..|.|.:||:|.:.|:.||||:.       |.|:....||    |...|  :::.
Worm   233 SLYTTIGYGNFHPLTKSGRIISMMYACIGIPLVFTILLDWGFLYFTWIEYGWNRFNENFCQKSLQ 297

  Fly   153 R---------RYKKYKMSTDMHYVPPQLGLITT---------------------------VVIAL 181
            |         |.::......:....|.|...||                           |....
Worm   298 RDMQRRIRRERIRRVGSELSLSSTAPLLHRTTTQLSNPVQHIESNHPLSPLDVDVPMGEQVQTVP 362

  Fly   182 IPGIALF----LLLPSWVFTYFE-NWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVV 241
            |...|:|    :::.:::...:| .|.|..:.|:.:.:.||||.||.|    ...|.     |::
Worm   363 IKSAAIFFFLWIMISAFIVRLWEYEWTYFTAFYFFFTSLTTIGLGDVV----TKTPN-----FII 418

  Fly   242 YQIFVIVWFIFSLGYLVMIM-----TFITRGLQSKKLAYLEQQLSSNLKATQNRIWSGVTKDVGY 301
            :.:.:.:..:..:|....|:     ....|.|:|....|..:|:..:: ||.:.:   ..::.|.
Worm   419 FNLAMTLIGLSVVGLCAAIVQAKVKLVFDRMLRSIDAQYRIRQVDPHV-ATMSIV---EDEEEGV 479

  Fly   302 LRRMLNELYILKVKFCRKGNRKKPKNKAKTEQKKKSSRYIAYTLPRSNSCPDLSMYRVEPAPIPS 366
            .|.:.::....::.|......||...|.:.:||......|..|                   .||
Worm   480 KRLIQSQSLEDRIIFLFVDEHKKSMLKERWKQKSTMVNRITQT-------------------YPS 525

  Fly   367 RKRAFSVCADMVAAQREAGMVHANSDTELSKLDREKTFETAEAYRQTTDLLAKVVNALATVKPPP 431
            :...:......|..||:      .||.:||..|.|..        :..:|..|::       |||
Worm   526 KADKYVQTGQRVYDQRQ------GSDEDLSDEDEEDV--------EYDELGNKII-------PPP 569

Fly 432 431
Worm 570 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	20/64 (31%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	18/93 (19%)
twk-24	NP_001367093.1	Ion_trans_2	<221..273	CDD:400301	16/51 (31%)
twk-24	NP_001367093.1	Ion_trans_2	368..442	CDD:400301	16/82 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010