DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ork1 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_742039.1	Gene:	Kcnk2 / 170899	RGDID:	621448	Length:	426	Species:	Rattus norvegicus

Alignment Length:	354	Identity:	98/354 - (27%)
Similarity:	164/354 - (46%)	Gaps:	57/354 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RW-----ILLLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDE 64
            :|     |.|::  :.||:.||.::..:|..:|    ..||...:...:..:.:....|:|..||
  Rat    58 KWKTVSTIFLVV--VLYLIIGATVFKALEQPQE----ISQRTTIVIQKQNFIAQHACVNSTELDE 116

  Fly    65 ILQRISDYCDKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIG 129
            ::|:|....:..:.......:....|....:||||.||.:|:|:|||||.|..|::..|.|:::|
  Rat   117 LIQQIVTAINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLG 181

  Fly   130 IPVNGILFAG----LGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGLITTVVIALIPGIALFLL 190
            ||:.|.|.||    ||..||:....:...:.|:.:|      ..::.:|:|::..|. |..||:.
  Rat   182 IPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVS------QTKIRIISTIIFILF-GCVLFVA 239

  Fly   191 LPSWVFTYFENWPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFV--IVWF--I 251
            ||:.:|.:.|.|....::|:..:|.|||||||||.          ||..:.|..|.  :|||  :
  Rat   240 LPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVA----------GGSDIEYLDFYKPVVWFWIL 294

  Fly   252 FSLGYLVMIMTFITRGLQ--SKKLAYLEQQLSSNLKATQNRIWSGVTKDVGYLRRMLN-ELYILK 313
            ..|.|...:::.|...|:  |||    .::.....:|......:.||.:....||.|: |:|
  Rat   295 VGLAYFAAVLSMIGDWLRVISKK----TKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIY--- 352

  Fly   314 VKFCRKGNRKKPKNKAKTEQKKKSSRYIA 342
                       .|.:..|..|:|.|..:|
  Rat   353 -----------DKFQRATSVKRKLSAELA 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	27/57 (47%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	28/87 (32%)
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	25/56 (45%)
		Ion_trans_2	234..312	CDD:285168	28/87 (32%)
		Required for basal channel activity. /evidence=ECO:0000250\|UniProtKB:P97438	354..426		6/17 (35%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250\|UniProtKB:P97438	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349061
Domainoid	1	1.000	66	1.000	Domainoid score	I9680
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm45417
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.840