DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ork1 and Kcnk1

DIOPT Version :9

Sequence 1:	NP_001285097.1	Gene:	Ork1 / 32020	FlyBaseID:	FBgn0017561	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	NP_032456.2	Gene:	Kcnk1 / 16525	MGIID:	109322	Length:	336	Species:	Mus musculus

Alignment Length:	352	Identity:	91/352 - (25%)
Similarity:	158/352 - (44%)	Gaps:	64/352 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRISDYC 73
            |::.|:.||:|||.::..:|...|.:.|.|.||    :....|||....:....::.|.|:.:..
Mouse    26 LVLGYLLYLVFGAVVFSSVELPYEDLLRQELRK----LKRRFLEEHECLSEPQLEQFLGRVLEAS 86

  Fly    74 DKPVTLPPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVNGILFA 138
            :..|::....... :.|.|..|.|||.||.||.|||:..|.:..|:...|.|||||||.. :||
Mouse    87 NYGVSVLSNASGN-WNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFT-LLF- 148

  Fly   139 GLGEYFGRTFEAIYRRYKKYKMSTDMHYVPPQLGL---ITTVVIALIPG---IALFLLLPSWVFT 197
                     ..|:.:|...:.....:.|...:.|.   :..:|.|::.|   ::.|..:|:.||:
Mouse   149 ---------LTAVVQRVTVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFS 204

  Fly   198 YFE-NWPYSISLYYSYVTTTTIGFGDYVPTFGANQP-KEFGGWFVVYQIFVIVWFIFSL-GYLVM 259
            ..| :|.:..|.|:.:::.:|||.|||||..|.||. :|      :|:|.:..:.:..| ..||:
Mouse   205 VLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRE------LYKIGITCYLLLGLIAMLVV 263

  Fly   260 IMTF--ITRGLQSKKLAYLEQQLSSNLKATQNR---IWSGVTKDVGYLRRMLNELYILKVKFCRK 319
            :.||  :....:.:|:.|:::....:|......   .:|.||:.|..|:
Mouse   264 LETFCELHELKKFRKMFYVKKDKDEDLVHIMEHDQLSFSSVTEQVAGLK---------------- 312

  Fly   320 GNRKKPKNKAKTEQKKKSSRYIAYTLP 346
                        |::|:|..::|...|
Mouse   313 ------------EEQKQSEPFVASQSP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	<90..144	CDD:285168	25/53 (47%)
Ork1	NP_001285097.1	Ion_trans_2	185..269	CDD:285168	27/88 (31%)
Kcnk1	NP_032456.2	Ion_trans_2	<100..157	CDD:285168	27/67 (40%)
		Selectivity filter 1. /evidence=ECO:0000250\|UniProtKB:O00180	117..122		3/4 (75%)
		Ion_trans_2	191..267	CDD:285168	25/81 (31%)
		Selectivity filter 2. /evidence=ECO:0000250\|UniProtKB:O00180	225..230		3/4 (75%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250\|UniProtKB:O00180	293..299		0/5 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..336		6/46 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm43345
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740