Protein Alignment Ork1 and Kcnk6

DIOPT Version :10

• Sequence 1: NP_001285097.1
• Gene: Ork1 / 32020
• FlyBaseID: FBgn0017561
• Length: 1019
• Species: Drosophila melanogaster
• Sequence 2: NP_446258.2
• Gene: Kcnk6 / 116491
• RGDID: 621450
• Length: 313
• Species: Rattus norvegicus
• Alignment Length: 273
• Identity: 71/273 - (26%)
• Similarity: 118/273 - (43%)
• Gaps: 46/273 - (16%)

  Fly    10 LIFYISYLMFGAAIYYHIEHGEEKISRAEQRKAQIAINEYLLEELGDKNTTTQDEILQRI--SDY 72
            |:.|..||..||.:...:|...|...|||..    .:.|.||...........|..::|:  :..
  Rat    11 LVAYAGYLALGALLVARLERPHEARLRAELG----TLREQLLRHSPCVAAHALDAFVERVLAAGR 71

  Fly    73 CDKPVTL----PPTYDDTPYTWTFYHAFFFAFTVCSTVGYGNISPTTFAGRMIMIAYSVIGIPVN 133
            ..:.|..    |....|.  .|.|..|.|||.|:.:|||||..:|.|.||:...|.::::|:|:.
  Rat    72 LGRAVLANASGPANASDP--AWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPIT 134

  Fly   134 GILFAGLGEYFGRTFEAIYRRYKKYKMSTDMHYVP-----------PQLGLITTVVIALIPGIAL 187
            .:|.....:                ::|..:.:.|           ||......:|..|:..:|:
  Rat   135 MLLLTASAQ----------------RLSLLLTHAPLSWLSLRWGWHPQRAARWHLVALLMVIVAI 183

  Fly   188 FLLLPSWVFTYFEN-WPYSISLYYSYVTTTTIGFGDYVPTFGANQPKEFGGWFVVYQIFVIVWFI 251
            |.|:|:.||.|.|. |.:..:.|:.:::.:|||.|||||.....||     :..:|::.|..:..
  Rat   184 FFLIPAAVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQP-----YRSLYKVLVTAYLF 243

  Fly   252 FSLGYLVMIM-TF 263
            ..|..:|::: ||
  Rat   244 LGLVAMVLVLQTF 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ork1	NP_001285097.1	Ion_trans_2	83..144	CDD:462301	21/60 (35%)
		Ion_trans_2	185..266	CDD:462301	26/81 (32%)
Kcnk6	NP_446258.2	Ion_trans_2	<89..146	CDD:462301	20/74 (27%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	106..111		4/4 (100%)
		Ion_trans_2	180..259	CDD:462301	26/82 (32%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	214..219		3/4 (75%)
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	282..290
		Lysosomal targeting signal. /evidence=ECO:0000269|PubMed:28381826	308..312