Protein Alignment HOXA5 and en

DIOPT Version :10

• Sequence 1: NP_061975.2
• Gene: HOXA5 / 3202
• HGNCID: 5106
• Length: 270
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 239
• Identity: 75/239 - (31%)
• Similarity: 106/239 - (44%)
• Gaps: 60/239 - (25%)

Human    74 AASASAAPAEPRYSQP-----ATSTHSPQPDPLPCSAVAPSPGSDSHHGGKNSLSNSSGASADAG 133
            |.|....||.|..:||     |:|..||.|      |...|..|.:.....:|.|:|||.|:.|.
  Fly   302 AVSQIGQPAAPTMTQPPLSSSASSLASPPP------ASNASTISSTSSVATSSSSSSSGCSSAAS 360

Human   134 STHISSREGVGTASGAEEDAPASSEQASAQSEPSPAPPA-------------------------Q 173
            |.:.|....:| |||:..:|      :|.|.:|.|.|.|                         :
  Fly   361 SLNSSPSSRLG-ASGSGVNA------SSPQPQPIPPPSAVSRDSGMESSDDTRSETGSTTTEGGK 418

Human   174 PQIYP-WMRKLHISHDNIGGP-------------EGKRARTAYTRYQTLELEKEFHFNRYLTRRR 224
            .:::| |:.....|.....||             :.||.|||::..|...|::||:.|||||.||
  Fly   419 NEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLARLKREFNENRYLTERR 483

Human   225 RIEIAHALCLSERQIKIWFQNRRMKWKKDNKLK---SMSMAAAG 265
            |.:::..|.|:|.||||||||:|.|.||....|   ::.:.|.|
  Fly   484 RQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQG 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXA5	NP_061975.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..175		34/129 (26%)
		Antp-type hexapeptide	176..181		2/5 (40%)
		Homeodomain	196..252	CDD:459649	30/55 (55%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	30/55 (55%)
		Engrail_1_C_sig	512..542	CDD:431338	3/16 (19%)