DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2186 and Rbm33

DIOPT Version :9

Sequence 1:	NP_001368978.1	Gene:	CG2186 / 32017	FlyBaseID:	FBgn0030243	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	NP_082510.1	Gene:	Rbm33 / 381626	MGIID:	1919670	Length:	1231	Species:	Mus musculus

Alignment Length:	1366	Identity:	295/1366 - (21%)
Similarity:	414/1366 - (30%)	Gaps:	540/1366 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DINDDLL---------------------------NYELGDDIDDQALLGADEDELLLSDEEL--- 37
            ::|||||                           ::||.|:.:||:  |..|.|....|:||
Mouse    66 ELNDDLLQSDNEEEENFSSQGVTISLNTTSGIVTSFELSDNTNDQS--GEQESEYEQGDDELAYH 128

  Fly    38 ---EKDV-TSEVKQQMRAEAE--EWAQEQIRQHERKHKEQLQADATAATEVTVAATATAEVAPTL 96
               |::: |.|..::.:.|..  |..::||...:...:|||.:|.....|:.
Mouse   129 KPEEQELYTQEYPEEGQYEGHDAELTEDQIEYGDEPEEEQLYSDEVLDIEIN------------- 180

  Fly    97 RAQPELASSPAPDPVPAKPLVAQVEKHVDTAHAAVAAEPAKELVSAS--RSESPQQ--QAKEEAP 157
                                                 ||..|.....  ::...||  |.:|
Mouse   181 -------------------------------------EPLDEFTDEEYLQAYGGQQGLQVRE--- 205

  Fly   158 PADCAEKEATQNNGNSEEQAENAGSQ--SEAERGLGLCSLLASSQESLPSASSASVISDPREDDE 220
              ||   ||      .::..|...||  ||...|         ..|:|.........||..:||:
Mouse   206 --DC---EA------EDDLDEITDSQVASETHEG---------GMETLELQKDIKEESDEEDDDD 250

  Fly   221 EREERTNYKTASERSDNNL----------RQQQEHAHMS-------------PYQHQQRRLHGHG 262
            |...|..:||  ||.:..:          |...|...:|             ..||:|.|   :|
Mouse   251 EESGRLRFKT--ERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGR---YG 310

  Fly   263 DKPRVGG--GGRFMHGQQQQQQQQQSQMGK-----------PPRGIGTRHHLLRNPSPSFGIQQQ 314
            .  |.||  ||..|......|::..|:.|:           .|..:.....|:..|.|
Mouse   311 S--RRGGRRGGSLMCRGMGDQRRDNSERGRMKEHRPALLPTQPSVVAHSPRLIPPPQP------- 366

  Fly   315 RMGMAGMQPPPQRYGMPGNAPPPQHLALMST--------------PVGAAPTAACLLPLTVPVTP 365
                   ||||     |...||||...:.|.              |...:|.....:|..:....
Mouse   367 -------QPPP-----PPPPPPPQQQPIRSLFQQQQLQPLLPLQHPHHPSPPQGVHMPPQIETPR 419

  Fly   366 LTLSIPQAHPSHQVHQQQQQTLSNPTF---IPIPGQYPATQPPNQ-----SPQQAPTNTQQPHSA 422
            :.|:.|...|     ||.:....||.|   :..|.|.|....|:|     .||:.|       ..
Mouse   420 MMLTPPPVTP-----QQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFP-------GP 472

  Fly   423 PASPLHTPTHSHMMHHSHNPNGGVLHHLLPHPHEQVRVGLLQPPPLAY-----APNPGGYRNGAL 482
            |..|.|||.                    |.|:     ...|||.|..     ||.|...|:...
Mouse   473 PEFPQHTPG--------------------PVPN-----SFNQPPRLPLQDQWRAPPPPQERDPFF 512

  Fly   483 LGPGPGPGLHQQHQSPH---QQQSGMRPPLYRNAPPSYGYDQGH--PPQHPQQFMRPHNGWRPQG 542
            ||....|..     ..|   :|:|...||     ||....:..|  |.|.|..|.:|...:..||
Mouse   513 LGVSGEPRF-----PSHLFLEQRSPPPPP-----PPPTLLNSSHPVPTQSPLPFTQPGPAFNQQG 567

  Fly   543 D-----NARMQRPPLQT--------------------LPPHM----MPGAP-------PNYANGM 571
            .     ..|..||.||.                    :||..    .||.|       ||....:
Mouse   568 QQPVFPRERPVRPALQPPGPVGILHFSQPGSATARPFIPPRQPFLPSPGQPFLPTHAQPNLQGPL 632

  Fly   572 GMRGPPPQQQQSQ-QPPQQQPAPQQAGNPLQQAVN-PGQPPQQPNGPPQQQGS--------SSVP 626
            ....|||.|.|.| |.|||||...|...|||..:. |.|||.|...|||.|..        |:.|
Mouse   633 HPPLPPPHQPQPQPQQPQQQPQHHQHQPPLQPPLQPPHQPPPQHQPPPQHQPQQHQHHHHLSAPP 697

  Fly   627 RVSKVLINPNFKGGVEAATNKFIKETHFMPAINSEAELLRQQVEFINKNRQYIEKRRMERSPPSS 691
            .....:..|.|:..|:.|..:        |: :|..:....|....|...|.|.||.|::..|::
Mouse   698 PPLMPMSQPQFRPHVQTAQPQ--------PS-SSRMQCTPHQGLRHNAASQNISKRPMQQMQPTA 753

  Fly   692 GSSTGAASSGQAGERRRTRSRSRSRGRSYSPVKRVERERERERERERDRERDRERDRERYGANRA 756
            ..:                  |..|....:|...:|                            .
Mouse   754 PRN------------------SNLRELPIAPSHVLE----------------------------M 772

  Fly   757 AGNRGFRRASSRDRDENRGAASTASAQGAGGSASSGAAPPKR----RRSGSAGGGTARNPFSGEP 817
            :|||               .:||..||   ..:....:||.|    .||..........|.|.|.
Mouse   773 SGNR---------------CSSTPVAQ---VKSIVNTSPPCRAVVSSRSSQGNTDAKAKPLSPEA 819

  Fly   818 RGRPSETGSRSMPSDEDEETRNYRLEIEKQKQLREKIMRDKELKRRRAAEEKLHEEKRAEQHNTS 882
            :.:.........| |||||||.|||:||:||:|||:|::.|||:|::
Mouse   820 QPKEEAKPEAEFP-DEDEETRLYRLKIEEQKRLREEILKQKELRRQQ------------------ 865

  Fly   883 PARDDQEVAAGQGSAAPTPAASKHRPTASAGERKVISLKRRDDQDASSVRSRQAQGSQSNAQAGQ 947
                                        .||.||            ..:..|.||..|...|...
Mouse   866 ----------------------------QAGARK------------KELLERLAQQQQQQQQQQH 890

  Fly   948 GQQQQQAARKQLTAAKIAPEAKRSITDHLAPSSKQHHHHHQQHHQTAAAPARTVVLGSGAVAGGT 1012
            ..||||...:|:..::.:.|                      ..:.||.|:.|         .|.
Mouse   891 QPQQQQQQPQQIYGSQTSME----------------------QEELAATPSPT---------NGN 924

  Fly  1013 P--PKPRDKLRLGTPSDDEVELDYDDDDLLLDEEDRLLATPSP------PPQKASSKRSATPEPL 1069
            |  |.|..:.|....:           .||:..:|...|:..|      ||......:.....||
Mouse   925 PLLPFPGAQCRQNVKT-----------RLLVKNQDITTASVQPKAVNFVPPGANVQHQGQHLRPL 978

  Fly  1070 VVKRN--HKAMRGGSSTSAPSFSSNQRRVVLKPTSNGSSSSGGDQQQLSHS----------GRQR 1122
            ...|.  ||.::                  :||.         |.::..||          ||.:
Mouse   979 KHLRQLPHKVLQ------------------VKPM---------DMEETPHSPQAARVTSLQGRPQ 1016

  Fly  1123 DRRRGGEDSALQRKGGVGSVGGSSSSGSGGGIFDRLEKRVAVSGGGSSGGGGGSSHKQRSKAPAR 1187
            |.:.|.:.:.:.|         ::|.|.|.|.....:.||....||..|...|.||.:..  |.|
Mouse  1017 DTKPGVKRTVMHR---------ANSGGGGDGPHVSSKVRVIKLSGGQGGESDGFSHTEGQ--PQR 1070

  Fly  1188 I 1188
            :
Mouse  1071 L 1071

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2186	NP_001368978.1	PHA03247	<323..629	CDD:223021	100/383 (26%)
Rbm33	NP_082510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..168		23/103 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..261		15/52 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..436		36/167 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	452..761		93/377 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..840		13/44 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	876..932		19/86 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	998..1080		21/85 (25%)
		RRM_SF	1161..1226	CDD:240668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	74	1.000	Domainoid score	I9076
eggNOG	1	0.900	-	-		E1_28IQQ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	75	1.000	Inparanoid score	I5259
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22014
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5746
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.080