DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2186 and Rbm33

DIOPT Version :9

Sequence 1:	NP_001368978.1	Gene:	CG2186 / 32017	FlyBaseID:	FBgn0030243	Length:	1193	Species:	Drosophila melanogaster
Sequence 2:	XP_017448166.1	Gene:	Rbm33 / 362297	RGDID:	1310651	Length:	1239	Species:	Rattus norvegicus

Alignment Length:	1305	Identity:	289/1305 - (22%)
Similarity:	407/1305 - (31%)	Gaps:	491/1305 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DINDDLL---------------------------NYELGDDIDDQALLGADEDELLLSDEEL--- 37
            ::|||||                           ::||.|:.:||:  |..|.|....|:||
  Rat    82 ELNDDLLQSDNEDEENFSSQGVTISLNTTSGIVTSFELSDNTNDQS--GEQESEYEQGDDELAYH 144

  Fly    38 ---EKDV-TSEVKQQMRAEAE--EWAQEQIRQHERKHKEQLQADATAATEVTVAATATAEVAPTL 96
               |::: |.|..::.:.|..  |..::||...:...:|||.:|.....|:.
  Rat   145 KPEEQELYTQEYPEEGQYEGHDTELTEDQIEYGDEPEEEQLYSDEVLDIEIN------------- 196

  Fly    97 RAQPELASSPAPDPVPAKPLVAQVEKHVDTAHAAVAAEPAKELVSAS--RSESPQQ--QAKEEAP 157
                                                 ||..|.....  ::...||  |.:|
  Rat   197 -------------------------------------EPLDEFTDEEYLQAYGGQQGLQVRE--- 221

  Fly   158 PADCAEKEATQNNGNSEEQAENAGSQ--SEAERGLGLCSLLASSQESLPSASSASVISDPREDDE 220
              ||   ||      .::..|...||  ||...|         ..|:|.........||..:||:
  Rat   222 --DC---EA------EDDLDEITDSQVASETHEG---------GMETLELQKDIKEESDEEDDDD 266

  Fly   221 EREERTNYKTASERSDNNL----------RQQQEHAHMS-------------PYQHQQRRLHGHG 262
            |...|..:||  ||.:..:          |...|...:|             ..||:|.|   :|
  Rat   267 EESGRLRFKT--ERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQHKQGR---YG 326

  Fly   263 DKPRVGG--GGRFMHGQQQQQQQQQSQMGKPPRGIGTRHHLLRNPSPSFGIQQQRMGMAGMQP-- 323
            .  |.||  ||..|......|::..|:.|:                    :::.|..:...||
  Rat   327 S--RRGGRRGGSLMCRGMGDQRRDNSERGR--------------------MKEHRPALLPTQPPV 369

  Fly   324 --------PPQRYGMPGNAPPPQHLALMST--------------PVGAAPTAACLLPLTVPVTPL 366
                    ||.:...|...||||...:.|.              |...:|.....:|..:....:
  Rat   370 VAHSPRLIPPPQQQPPPPPPPPQQQPIRSLFQQQQLQPLLPLQHPHHPSPPQGVHMPPQIETPRM 434

  Fly   367 TLSIPQAHPSHQVHQQQQQTLSNPTF---IPIPGQYPATQPPNQ-----SPQQAPTNTQQPHSAP 423
            .|:.|...|     ||.:....||.|   :..|.|.|....|:|     .||:.|       ..|
  Rat   435 MLTPPPVTP-----QQPKNIHINPHFKGTVVTPVQVPLLPVPSQPRPAVGPQRFP-------GPP 487

  Fly   424 ASPLHTPTHSHMMHHSHNPNGGVLHHLLPHPHEQVRVGLLQPPPLAY-----APNPGGYRNGALL 483
            ..|.|||.                    |.|:     ...|||.|..     ||.|...|:...|
  Rat   488 EFPQHTPG--------------------PVPN-----SFNQPPRLPLQDQWRAPPPPQERDPFFL 527

  Fly   484 GPGPGPGLHQQHQSPH---QQQSGMRPPLYRNAPPSYGYDQGH--PPQHPQQFMRPHNGWRPQGD 543
            |....|..     ..|   :|:|...||     ||....:..|  |.|.|..|.:|...:..||.
  Rat   528 GVSGEPRF-----PSHLFLEQRSPPPPP-----PPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQ 582

  Fly   544 -----NARMQRPPLQT--------------------LPPHM----MPGAP-------PNYANGMG 572
                 ..|..||.||.                    :||..    .||.|       ||....:.
  Rat   583 QPVFPRERPVRPALQPPGPVGILHFSQPGSATARPFIPPRQPFLPSPGQPFLPTHAQPNLQGPLH 647

  Fly   573 MRGPPPQQQQSQ-QPPQQQPAPQQAGNPLQQAVN-PGQPPQQPNGPPQQQGS--------SSVPR 627
            ...|||.|.|.| |.|||||...|...|||..:. |.|||.|...|||.|..        |:.|.
  Rat   648 PPLPPPHQPQPQPQQPQQQPQHHQHQPPLQPPLQPPHQPPPQHQPPPQHQPQQHQHHHHLSAPPP 712

  Fly   628 VSKVLINPNFKGGVEAATNKFIKETHFMPAINSEAELLRQQVEFINKNRQYIEKRRMERSPPSSG 692
            ....:..|.|:..|:.|          .|..||.                     ||:.:|
  Rat   713 PLMPMSQPQFRPHVQTA----------QPQSNSS---------------------RMQCTP---- 742

  Fly   693 SSTGAASSGQAGERRRTRSRSRSRGRSYSPVKRVERERERERERERDRERDRERDRERYGANRAA 757
                     :.|.|..|.|::.|:    .|:::::....|....       ||...........:
  Rat   743 ---------RQGLRHNTASQNISK----RPMQQMQPTAPRNSNL-------RELPIAPSHVLEMS 787

  Fly   758 GNRGFRRASSRDRDENRGAASTASAQGAGGSASSGAAPPKR----RRSGSAGGGTARNPFSGEPR 818
            |||               .:||.:||   ..:.:..:||.|    .||..........|.|  |.
  Rat   788 GNR---------------CSSTPAAQ---VKSIANTSPPCRAVVASRSSQGKTDAKAKPLS--PG 832

  Fly   819 GRPSETGSRSMP-SDEDEETRNYRLEIEKQKQLREKIMRDKELKRRRAAEEKLHE--EKRAEQHN 880
            .:|.|....... .|||||||.|||:||:||:|||:|::.|||:|::.|..:..|  |:.|:|..
  Rat   833 AQPKEEAKAEAEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQ 897

  Fly   881 TSPARDDQEVAAGQGSAAP--------TPAASKHRPTASAGERKVISLKRRDDQDASSVRSRQAQ 937
            ....:..|:.....||..|        ||:.:...|.          |.....|...:|::|...
  Rat   898 QQQQQQQQQQQQIYGSQTPMEQEELAATPSPTNGNPL----------LPFPGTQCRQNVKTRLLV 952

  Fly   938 GSQSNAQAGQGQQQQQAARKQLTAAKIAPEAKRSITDHLAPSSKQHH---------HHHQQHHQT 993
            .:|                 .:|||.:.|:|    .:.:.|.:...|         |..|..|:.
  Rat   953 KNQ-----------------DVTAANVQPKA----VNFVPPGANMQHQGQHLRPLKHLRQLPHKV 996

  Fly   994 AAAPARTVVLGSGAVAGGTPPKPRDKLRLGTPSDDEVELDYDDDDLLLDEEDRLLATPSPPPQKA 1058
            ...                  ||.|.                       ||     ||..|....
  Rat   997 LHV------------------KPMDM-----------------------EE-----TPHSPQAAR 1015

  Fly  1059 SSKRSATPEPLV--VKRN--HKAMRGGSSTSAPSFSSNQRRVVLKPTSNGSSSSGGDQQQLSHSG 1119
            .:.....|:...  |||.  |:|..||.. ..|..||..|.:.|      |...||:....||:.
  Rat  1016 VTSLQGRPQDTKPGVKRTVMHRANSGGGG-DGPHVSSKVRVIKL------SGGQGGESDGFSHTE 1073

  Fly  1120 RQRDR 1124
            .|..|
  Rat  1074 GQPQR 1078

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2186	NP_001368978.1	PHA03247	<323..629	CDD:223021	100/393 (25%)
Rbm33	XP_017448166.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I7205
eggNOG	1	0.900	-	-		E1_28IQQ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I4955
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22014
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.050