Protein Alignment CG2186 and RBM33

DIOPT Version :9

• Sequence 1: NP_001368978.1
• Gene: CG2186 / 32017
• FlyBaseID: FBgn0030243
• Length: 1193
• Species: Drosophila melanogaster
• Sequence 2: XP_005249588.1
• Gene: RBM33 / 155435
• HGNCID: 27223
• Length: 1221
• Species: Homo sapiens
• Alignment Length: 1380
• Identity: 307/1380 - (22%)
• Similarity: 442/1380 - (32%)
• Gaps: 484/1380 - (35%)

  Fly     2 SDINDDLLNYEL------GDDIDDQALLGADEDELLLSDEELEKDVTSE---------------- 44
            |::.||||..:|      ..|:.|:.|    .|:||.||.|.|::.:|:
Human    41 SELEDDLLGEDLLSGKKNQSDLSDEEL----NDDLLQSDNEDEENFSSQGVTISLNATSGMVTSF 101

  Fly    45 -----VKQQMRAEAEEWAQEQIRQHERKHKEQLQADATAATEVTVAATATAEVAPTLRAQPELAS 104
                 ...|...:..|:.|||.......||    :|.:                       ||.:
Human   102 ELSDNTNDQSGEQESEYEQEQGEDELVYHK----SDGS-----------------------ELYT 139

  Fly   105 SPAPDPVPAKPLVAQVEKHVDTAHAAVAAEPAKELVSASRSESPQQQ---------AKEEAPPAD 160
            ...|:.       .|.|     .|.|...|...|.|     |.|:::         .:...|..:
Human   140 QEYPEE-------GQYE-----GHEAELTEDQIEYV-----EEPEEEQLYTDEVLDIEINEPLDE 187

  Fly   161 CAEKEATQNNGNSE--EQAENAGSQSE------------AERGLGLCSLLASSQESLPSASSASV 211
            ..::|..|..|..:  ::.|:..::.|            .|.|         ..|:|........
Human   188 FTDEEYLQAYGGQQGLQEQEDCVAEDELDEITDAQVAPATEEG---------GMETLELQKDIKE 243

  Fly   212 ISDPREDDEEREERTNYKTASE-----------RSDNNLRQQQE-----HAHMSPYQHQQRRLHG 260
            .||..|:|:|...|..:||..:           |...|:.:..|     .|.:..::.::|:
Human   244 ESDEEEEDDEESGRLRFKTERKEGTIIRLSDVTRERRNIPETLELSAEAKAALLEFEERERQ--- 305

  Fly   261 HGDKPRVGGGGRFMHGQQQQQQQQQSQMGKP--PRGIGTRHHLLRNPSPSFG-IQQQRMGMAGMQ 322
                          |.|.:...::..:.|.|  .||:|.:    |..|...| ::..|..:...|
Human   306 --------------HKQGRYSSRRGGRRGGPLMCRGVGDQ----RRESTERGRMKDHRPALLPTQ 352

  Fly   323 P----------PPQRYGMPGNAPPPQHLALMSTPVGAAPTAACLLPLTVPVTPLTLSIPQAHPSH 377
            |          |||....|...||||.          .|..:...|  .|:.||   :|..||.|
Human   353 PPVVTHSPRLIPPQPQAPPPPPPPPQQ----------QPIRSLFQP--QPLQPL---LPVQHPHH 402

  Fly   378 QVHQQQQQTLSNPTFIPIPGQYPATQPPNQSPQQAPTNTQQPHSAPASP-----LHTPTHSHMMH 437
            .         |.|..:.:|   |..:.|.......|...|||.:...:|     :.||....::.
Human   403 P---------SPPQGMHMP---PQLETPRMMMTPPPVTPQQPKNIHINPHFKGTVVTPVQVPLLP 455

  Fly   438 HSHNPNGGVLHHLLPHPHE-------QVRVGLLQPPPLAY-----APNPGGYRNGALLGPGPGPG 490
            ....|...|.....|.|.|       .|.....|||.|..     ||.|...|:...||....|.
Human   456 VPSQPRPAVGPQRFPGPPEFPQHTPGPVPNSFSQPPRLPLQDQWRAPPPPQDRDPFFLGVSGEPR 520

  Fly   491 LHQQHQSPH---QQQSGMRPPLYRNAPPSYGYDQGH--PPQHPQQFMRPHNGWRPQGD-----NA 545
            .     ..|   :|:|...||     ||....:..|  |.|.|..|.:|...:..||.     ..
Human   521 F-----PSHLFLEQRSPPPPP-----PPPTLLNSSHPVPTQSPLPFTQPGPAFNQQGQQPVFPRE 575

  Fly   546 RMQRPPLQT--------------------LPPHMM----PGAP-------PNYANGMGMRGPPPQ 579
            |..||.||.                    :||...    ||.|       ||....:....|||.
Human   576 RPVRPALQPPGPVGILHFSQPGSATTRPFIPPRQPFLPGPGQPFLPTHTQPNLQGPLHPPLPPPH 640

  Fly   580 QQQSQQPPQQQPAPQQAGNPLQQAVNPGQPPQQ--------PNGPPQQQGSS-----SVPRVSKV 631
            |.|.|| |||||.||.  .|..|.  |.|||.|        |..|||.|...     |||....:
Human   641 QPQPQQ-PQQQPPPQH--QPPHQP--PHQPPPQHQPPPQHPPQHPPQHQHHHHHHHLSVPPPPLM 700

  Fly   632 -LINPNFKGGVEAATNKFIKETHFMPAINSEAELLRQQVEFINKNRQYIEKRRMERSPPSSGSST 695
             :..|.|:..|:.|..:         |.:|..:..::|....|...|.:.||.|::..|::..:
Human   701 PMSQPQFRPHVQTAQPQ---------ASSSRMQCPQRQGLRHNTTSQNVSKRPMQQMQPTAPRN- 755

  Fly   696 GAASSGQAGERRRTRSRSRSRGRSYSPVKRVERERERERERERDRERDRERDRERYGANRAAGNR 760
                             |..|....:|...:|
Human   756 -----------------SNLRELPIAPSHVIE--------------------------------- 770

  Fly   761 GFRRASSRDRDENRGAASTASAQGAGGSASSGAAPPKRRRSG--SAGGGTARNPFSGEPRGRPSE 823
               .:|||       .::|.|||   ......|:||.|..:|  |:.|.|........|..:|.|
Human   771 ---MSSSR-------CSATPSAQ---VKPIVSASPPSRAVAGSRSSQGKTEVKVKPASPVAQPKE 822

  Fly   824 TGSRSMP-SDEDEETRNYRLEIEKQKQLREKIMRDKELKRRRAAEEKLHE--EKRAEQHN---TS 882
            ....... .|||||||.|||:||:||:|||:|::.|||:|::.|..:..|  |:.|:|..   ..
Human   823 EAKTETEFPDEDEETRLYRLKIEEQKRLREEILKQKELRRQQQAGARKKELLERLAQQQQQLYAP 887

  Fly   883 PARDDQEVAAGQGSAAPTPA-ASKHRPTASAGERKVIS---LKRRDDQDASSVRSRQAQGSQSNA 943
            |...:||    :.:.:|:|. .:...|...|..|:.:.   |.:..|...|:|:.:.:....|:|
Human   888 PPPAEQE----EQALSPSPTNGNPLLPFPGAQVRQNVKNRLLVKNQDVSISNVQPKTSNFVPSSA 948

  Fly   944 QAGQGQQQQQAARKQLTAAKIAPEAKRSITDHLAPSSKQHHHHHQQHHQTAAAPARTVVLGSGAV 1008
            .. |.|.||..|.|.|...:..|                         |:...|...|:
Human   949 NM-QYQGQQMKALKHLRQTRTVP-------------------------QSQTQPLHKVL------ 981

  Fly  1009 AGGTPPKPRDKLRLGTPSDDEVELDYDDDDLLLDEEDRLLATP-------SPPPQKASSKRSATP 1066
                |.||.|.                       ||..:..||       .|...|...||:.|
Human   982 ----PIKPADV-----------------------EEPAVPQTPRVASIQGRPQDTKPGVKRTVT- 1018

  Fly  1067 EPLVVKRNHKAMRGGSSTSAPSFSSNQRRVVLKPTSNGSSSS----GGDQQQLSHS---GRQRDR 1124
                    |:...||.  ..|..||..|.:.|.....|.|..    .|..|:|...   |.|..|
Human  1019 --------HRTNSGGG--DGPHISSKVRVIKLSGGQGGESDGFFHPEGQPQRLPQPPEVGPQPAR 1073

  Fly  1125 R----RGGEDSALQR--------------KGGVGSVGG------SSSSGSGGGIFDRLEKRVAVS 1165
            :    |||    ||:              ..|:.|:.|      :...|.|.|:
Human  1074 KVTLTRGG----LQQPPHLPAGPHAHSPVPPGIKSIQGIHPAKKAIMHGRGRGV----------- 1123

  Fly  1166 GGGSSGGGGGSSHKQ 1180
             .|..|.|....:||
Human  1124 -AGPMGRGRLMPNKQ 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2186	NP_001368978.1	PHA03247	<323..629	CDD:223021	103/386 (27%)
RBM33	XP_005249588.1	RRM_SF	1151..1216	CDD:240668

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7164
eggNOG	1	0.900	-	-		E1_28IQQ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I5016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22014
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5746
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.080