DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sofe and prc1b

DIOPT Version :9

Sequence 1:	NP_001285092.1	Gene:	sofe / 32016	FlyBaseID:	FBgn0030242	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_956528.1	Gene:	prc1b / 393203	ZFINID:	ZDB-GENE-040426-777	Length:	605	Species:	Danio rerio

Alignment Length:	594	Identity:	153/594 - (25%)
Similarity:	258/594 - (43%)	Gaps:	88/594 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RMFEPQACED--CLARLKDHVHTFYTDLRKETSDKEQGILNDIAVLRNEASGL------------ 77
            |..|..|.|.  ||.:...|:    .|:.:|....|...|....|::|...||
Zfish     2 RKSEVIAAESVACLNKALCHL----KDIWEEIGIPEDQRLERTNVVKNHVKGLLDMMIAEEESLR 62

  Fly    78 RRLL------HK-----AVDIGERPDDVPMEIWYIKLEK----YIEQLRKELVSRRAEIRELLHQ 127
            :||:      ||     .:::...|.........::.||    ::|.:.||...|...::.|..|
Zfish    63 KRLMTSIEKCHKELSKLCLELQSPPFQEEKSGTMLQREKELRTHVEVMLKEKNQRMQALKALTEQ 127

  Fly   128 QQQLCDELGEQPLSLLADPLPLPEEMDPFREHLAQLRDQRVQRLRDMDELRQNIKRNIKLLELQL 192
            .|.|||.|..||.|:....:|..|:::.|.:|::.|..::.:|.::...|::.|...:..|:...
Zfish   128 DQDLCDLLCSQPFSISPGCVPSMEQLENFHQHISCLTAEKERRHKEFVTLKKQIILCMDDLDQLP 192

  Fly   193 RTDSEKRLLNADNHKLTPYAYVRLQEMDKEFADQVQDLIDRID-----------EMRGKIECLWQ 246
            .|..||.::..|.....         :.||..|.::.|:.:::           ..|.||..||:
Zfish   193 ETSFEKDVVCEDEESFC---------LSKENIDSLKVLLQQLENRKAENERVCGSYREKILELWK 248

  Fly   247 RLRMTDEYAMRRVREATSYNQCTYDILREELERCQAMRQQNLIAFIEQLRIEINEWWDLSLKSTE 311
            ||::..|.........|...:...:.|:.|::|.:.::.:|:....|.||.||..:|:....|.:
Zfish   249 RLQIPQEERDVISEHMTLSKKRNMEALQVEVKRLEELKLKNMQNVTETLRKEIAVYWEKCFYSAD 313

  Fly   312 ERRRFTTYYCDTQTEDVLEQFEKELDNLKEFYNSNRKIFELYANRGELWTRMEALEAKANDPNRF 376
            :|:.|..||.|..:|::|...:.|:..||::|..::::||......|.|.....||.:|.||:||
Zfish   314 QRQAFMPYYDDDFSEELLSLHDAEIVQLKQYYEDHKELFEGVHKWEENWRLFIELEERAKDPSRF 378

  Fly   377 NNRGGQLLKEEKERKTIMSRLPKIDQQITELVQVYMSETHTPFLVHGVDILERMSADWERHRQSK 441
            .||||.||||||:|..|:..|||:::::...::.:..|.:..|.|:|...::.:|..||.:|..|
Zfish   379 TNRGGNLLKEEKQRADIVKGLPKLEKKLKAEIEQWELEQNREFQVNGQKFMQFVSDQWELYRLEK 443

  Fly   442 KQPSAQK--KDGSNTSGQMKPPMVPLTPNTQKSNRGIHGSTSSLKKTPTKANASTTAMSTGNLHK 504
            ::...::  |....|...|....|..||    :.|...|||     ||.||.......|||..:.
Zfish   444 EREKQERQLKKSKQTEEDMVYGTVIRTP----TKRRFLGST-----TPCKARKLNATSSTGTSNS 499

  Fly   505 RRH-----PQHHNTNSPQPAAAAKRNLIAS-----------LECNNASRKVC-----VNGQ-KLL 547
            ...     ...|:..|..|.:|:|.|.:.:           ||.|  ...:|     |.|. |:.
Zfish   500 TIRSVIGGTVCHSPISRPPISASKGNGVKTPGHSKPPHQGLLERN--KENICHLTGGVAGMTKVP 562

  Fly   548 KSPQRKVRV 556
            .||||...:
Zfish   563 ASPQRNFSI 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sofe	NP_001285092.1	MAP65_ASE1	36..598	CDD:281928	149/585 (25%)
prc1b	NP_956528.1	MAP65_ASE1	37..592	CDD:281928	143/555 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3240
eggNOG	1	0.900	-	-		E1_KOG4302
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3891
OMA	1	1.010	-	-		QHG55705
OrthoDB	1	1.010	-	-		D272248at2759
OrthoFinder	1	1.000	-	-		FOG0001893
OrthoInspector	1	1.000	-	-		mtm6397
orthoMCL	1	0.900	-	-		OOG6_103576
Panther	1	1.100	-	-	O	PTHR19321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3175
SonicParanoid	1	1.000	-	-		X857
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870