DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment feo and ASE1

DIOPT Version :9

Sequence 1:	NP_572658.2	Gene:	feo / 32015	FlyBaseID:	FBgn0030241	Length:	671	Species:	Drosophila melanogaster
Sequence 2:	NP_116582.1	Gene:	ASE1 / 854223	SGDID:	S000005584	Length:	885	Species:	Saccharomyces cerevisiae

Alignment Length:	733	Identity:	160/733 - (21%)
Similarity:	283/733 - (38%)	Gaps:	148/733 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSPSAIA------VKAQILEMTGEHVDQLHAMWSQLFEVKTC---------GEFLLRLKDHANS 50
            :|.||.|.      ::..||....:.|.|.......|...|..         |.||.||:|:..|
Yeast   169 INDPSGIKTIPDLYIRNAILLQESKTVPQSPKKPLSLLSKKAALDTAKKFVLGSFLPRLRDYLKS 233

  Fly    51 FFT--DLLNESREKQQAILNDIAALRAEATDLTRLLHEPLDI----GERPESMPLVVWELK---- 105
            ..|  .|:...:|....:........||..:|:.|....|.|    |:...||..::...|
Yeast   234 LITLKHLIQSVKENLPGLTEADNEAIAEFPELSTLTAYLLQIENGKGDIGLSMKFIIDNRKDILK 298

  Fly   106 -------LDKSIEHL-------RDQLARRRAEICELLLQQEQLCEELGELPLPLLADPLPLPEEM 156
                   .::|::|:       .::..||...:....:....:||:|| .||..|
Yeast   299 GSAFKTINEESVKHMNEVIKIYEEEYERRFKSVLTKKVSISSICEQLG-TPLATL---------- 352

  Fly   157 DAFRNRLGQLRDQRVLRLKEMDQLRQAIKHDMKLLECLPQTDTEERLLNQVDHCLTPETFELLRN 221
                  :|:..:|.:....|.:.....|.:       ....|.|.  ::::|     .|.|.|:.
Yeast   353 ------IGEDFEQDLRSYGEEENSTSEIPN-------FHPVDRER--MSKID-----ITLEKLQA 397

  Fly   222 MQKNFADQVKELRERIDDMREKIHVLWDRLQETDEYAMRRVREATTYTQRTYDVLREELQRCQAL 286
            :.|..||:.:.|.|:...       ||.||:.:.||....:|..::.:..:...:.:|:.|.:|:
Yeast   398 IHKERADKKRLLMEQCQK-------LWTRLKISQEYIKTFMRNNSSLSTESLGRISKEVMRLEAM 455

  Fly   287 RRQNLKTFIEQLRIEIKEMWDLTLKSQQERKRFSNYYNDWYN------ED--LLELHELELDDLK 343
            :::.:|..|.....:|:|:|.....|::.|.:|...:.:..|      ||  |||..|.||..|:
Yeast   456 KKKLIKKLISDSWDKIQELWRTLQYSEESRSKFIIVFEELRNSATTLQEDELLLETCENELKRLE 520

  Fly   344 TFYNKNKEIFDLYESRAELWSRMEALEAKASEPNRFNNRGGQ--LLKEEKERKAITSKLPKIEQQ 406
            ......|.|..|......|....|.||..:.:.:|..:|...  ||.|||.||.||...|::...
Yeast   521 EKLTLYKPILKLISDFESLQEDQEFLERSSKDSSRLLSRNSHKILLTEEKMRKRITRHFPRVIND 585

  Fly   407 ITELVQAYEAQENTPFLVHGENILE-------RMAADWERHRQAKQQSSARKKAPPSASKIMPPP 464
            :...::..:...:.|||..|:.:.|       .:.|.:.|.|...|:|...|......:|::.
Yeast   586 LRIKLEEADGLFDQPFLFKGKPLSEAIDIQQQEIEAKYPRCRVRMQRSKKGKCGANKENKVIK-- 648

  Fly   465 ATGSTAPRTPRTLRNMSTLSSSTMSLR-KTPSQQHLRPL---------NITKSTGNLHKRLNPSG 519
               :|...|..::|....|:.:..::. ||||::.::.|         ::.:......|..:|:.
Yeast   649 ---NTFKATESSIRVPIGLNLNDANITYKTPSKKTIQGLTKNDLSQENSLARHMQGTTKLSSPNR 710

  Fly   520 LQTGPKTP---------NAKRSLMNTLNS--MKASP------AKHLLAPSQQH----NQL--KST 561
            ..|....|         |.:|..:|...|  :.:||      .:|.:.|.|..    |::  |.:
Yeast   711 RATRLLAPTVISRNSKGNIERPTLNRNRSSDLSSSPRINHTHGEHAVKPRQLFPIPLNKVDTKGS 775

  Fly   562 KSP-LKRVRVLDNTLRRSGGMGRRSIGTRSSKKARTKSNDQNAPPDSSDYTTDENPEQGVSYDEF 625
            ..| |.:.:.|:...|.:|..|:.::  ||.:  |..|.:..|...||.|   :.||..:
Yeast   776 HIPQLTKEKALELLKRSTGTTGKENV--RSPE--RKSSLEDYAQKLSSPY---KEPEHSI----- 828

  Fly   626 QPTSRSSMLPRQRHQLAV 643
               .:.||.|..:.||.:
Yeast   829 ---YKLSMSPEGKFQLNI 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
feo	NP_572658.2	MAP65_ASE1	39..613	CDD:281928	142/648 (22%)
ASE1	NP_116582.1	MAP65_ASE1	121..800	CDD:397896	145/673 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4302
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5674
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001893
OrthoInspector	1	1.000	-	-		otm46645
orthoMCL	1	0.900	-	-		OOG6_103576
Panther	1	1.100	-	-	O	PTHR19321
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3175
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790