DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CRZ1

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	640	Identity:	140/640 - (21%)
Similarity:	230/640 - (35%)	Gaps:	177/640 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 RSPQLKARGAEAASQTDQVALLPCEMCH-----DQFLNSLELRLHRNQVHRTTKEATSAGTDGLP 186
            ::|.||...:: ..|.|.: |.|.:..|     :|||:.      |:....||:   |:|.|...
Yeast   140 QTPTLKVEQSD-TFQWDDI-LTPADNQHRPSLTNQFLSP------RSNYDGTTR---SSGIDSNY 193

  Fly   187 SEDFKCKFCPQHFPHL--RQLRSHLARSH--------EQTARLQCAHCQRTFSRRDHLLRHIRNQ 241
            | |.:..:   |.|:|  :.|.|..|.||        :....:...:.........|..:||.|
Yeast   194 S-DTESNY---HTPYLYPQDLVSSPAMSHLTANNDDFDDLLSVASMNSNYLLPVNSHGYKHISN- 253

  Fly   242 HRDVEEDLLR-TWPPADENTMN-SDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSNEDDG 304
             .|..:|||. |:  :|.|.:: |:..|...|...::|..|.::..:.    .|.:.:
Yeast   254 -LDELDDLLSLTY--SDNNLLSASNNSDFNNSNNGIINTADTQNSTIA----INKSKV------- 304

  Fly   305 EEANGANQTLWLHI----KPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIA 365
                |.||.:.|.|    .|.|...|..|...:.::                            .
Yeast   305 ----GTNQKMLLTIPTSSTPSPSTHAAPVTPIISIQ----------------------------E 337

  Fly   366 IGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLDDDDDDDDEE 430
            ..:..|.:|.|       |:..:            :|.:.|.|.:.  |.::::|...||:|...
Yeast   338 FNEGHFPVKNE-------DDGTL------------QLKVRDNESYS--ATNNNNLLRPDDNDYNN 381

  Fly   431 DAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHLLRHKLS 495
            :|..|.|..|   ::.::|.| ||..||    |||:....|         .:|:.........:|
Yeast   382 EALSDIDRSF---EDIINGRK-LKLKKS----RRRSSQTSN---------NSFTSRRSSRSRSIS 429

  Fly   496 HLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGL-- 558
            ..||......:..|....:|.|.:....  :|:|...:..:.:::.:::...::  .:|...|
Yeast   430 PDEKAKSISANREKLLEMADLLPSSEND--NNRERYDNDSKTSYNTINSSNFNE--DNNNNNLLT 490

  Fly   559 -EPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHTDFLYACKTCDETFRERAQLR---EHEKT 619
             :|..|..:...::..:..||...        .||..|.|       ..|.::...:   .||..
Yeast   491 SKPKIESGIVNIKNELDDTSKDLG--------ILLDIDSL-------GQFEQKVGFKNDDNHENN 540

  Fly   620 HTG----------------------QRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKA 662
            ..|                      ..||.|.:||..|.|...|:.|:|.|..|:|:.|..|.||
Yeast   541 DNGTFSVKKNDNLEKLDSVTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFICSICGKA 605

  Fly   663 FPRATDLKVHERYHTGTKPNLCN---------TCGKSFHRAYNLTIHMRTHTGER 708
            |.|..|.|.||..|||.|..:|.         .|||.|.|:..|..|.:|.:|.|
Yeast   606 FARQHDRKRHEDLHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368	5/25 (20%)
		C2H2 Zn finger	192..213	CDD:275370	6/22 (27%)
		C2H2 Zn finger	221..239	CDD:275370	2/17 (12%)
		COG5048	<443..730	CDD:227381	71/303 (23%)
		C2H2 Zn finger	476..496	CDD:275368	1/19 (5%)
		zf-H2C2_2	488..513	CDD:290200	4/24 (17%)
		C2H2 Zn finger	504..525	CDD:275368	3/20 (15%)
		C2H2 Zn finger	532..548	CDD:275368	0/15 (0%)
		C2H2 Zn finger	573..593	CDD:275368	3/19 (16%)
		C2H2 Zn finger	600..620	CDD:275368	3/22 (14%)
		zf-H2C2_2	613..637	CDD:290200	9/48 (19%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	9/22 (41%)
		C2H2 Zn finger	656..676	CDD:275368	10/19 (53%)
		C2H2 Zn finger	684..704	CDD:275368	8/28 (29%)
		zf-C2H2	684..704	CDD:278523	8/28 (29%)
		zf-H2C2_2	696..721	CDD:290200	5/13 (38%)
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	739..755	CDD:275368
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	124/595 (21%)
		C2H2 Zn finger	571..591	CDD:275368	8/19 (42%)
		C2H2 Zn finger	599..619	CDD:275368	10/19 (53%)
		C2H2 Zn finger	627..655	CDD:275368	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100