DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2202 and ZBTB17

DIOPT Version :9

Sequence 1:NP_572657.2 Gene:CG2202 / 32014 FlyBaseID:FBgn0030240 Length:889 Species:Drosophila melanogaster
Sequence 2:NP_001274532.1 Gene:ZBTB17 / 7709 HGNCID:12936 Length:810 Species:Homo sapiens


Alignment Length:665 Identity:178/665 - (26%)
Similarity:268/665 - (40%) Gaps:148/665 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   252 TWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSNEDDGEE--------AN 308
            |.|..:...:.::|||:....|.:.....:..|..|     .:.||..:.|..||        |:
Human   119 TSPGGNAEALATEGGDKRAKEEKVATSTLSRLEQAG-----RSTPIGPSRDLKEERGGQAQSAAS 178

  Fly   309 GANQTLW---------LHIKPEPC--LEAEEVDLAM------QLKLEKKRRRREKAEAQAETSID 356
            ||.||..         :.:||:|.  :.|.|.:.|:      ::::|..|:..|:.:.|.|    
Human   179 GAEQTEKADAPREPPPVELKPDPTSGMAAAEAEAALSESSEQEMEVEPARKGEEEQKEQEE---- 239

  Fly   357 RTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLD 421
                .|....|.::  :|||    ||..|             :||.|                  
Human   240 ----QEEEGAGPAE--VKEE----GSQLE-------------NGEAP------------------ 263

  Fly   422 DDDDDDDEEDAGDDDDGEFRLKQEPLDGE-KPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSR 485
              :::::||.||.|...|       |..| :.|:....|  .|..:|...:..::||.|.:.|:.
Human   264 --EENENEESAGTDSGQE-------LGSEARGLRSGTYG--DRTESKAYGSVIHKCEDCGKEFTH 317

  Fly   486 HCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKV 550
            ..:..||...|..:||.:|..|.|||:.....|||.::....|.:.|..|..::..:..|..|| 
Human   318 TGNFKRHIRIHTGEKPFSCRECSKAFSDPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHK- 381

  Fly   551 SKHNGEG----------LEPGSELKLQLAEHT------CEYCSKRFSSKTYLRKHTLLH-TDFLY 598
            .:|:||.          ......||.....|:      |:||.:.||..|...:|...| ||..:
Human   382 KRHSGEARYRCEDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEH 446

  Fly   599 ACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAF 663
            .|..||:.|.:...|:.|.|.|.......|..||..|..:..|:.|:|.|:|||||.|..|.:.|
Human   447 KCPHCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQF 511

  Fly   664 PRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAH 728
            .....|:.|.|.|||.||..|..|||:|.:|.:|..|:|.||||:||.|::|.|.|.||:.|..|
Human   512 ADPGALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQHTGEKPYVCERCGKRFVQSSQLANH 576

  Fly   729 IRR----------------------------HTGER-YKCPHCDAYFLQLYNMRNHCMSAHN--- 761
            ||.                            ||||: |.|..|...|.::.|:|:|..:.|.   
Human   577 IRHHDNIRPHKCSVCSKAFVNVGDLSKHIIIHTGEKPYLCDKCGRGFNRVDNLRSHVKTVHQGKA 641

  Fly   762 --KHIETKTGRLQRTGLLDD----GGQSHLTTVVMP---PARYPNELDPQLAATAAATAAGGAES 817
              |.:|.:.|.......:||    ..::...|.|..   ||..|..:....|.||..|....||.
Human   642 GIKILEPEEGSEVSVVTVDDMVTLATEALAATAVTQLTGPATLPAVVPVGAAVTADETEVLKAEI 706

  Fly   818 TSSTTVI--HSPGTY 830
            :.:...:  ..|.|:
Human   707 SKAVKQVQEEDPNTH 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2202NP_572657.2 zf-AD 45..121 CDD:285071
C2H2 Zn finger 150..171 CDD:275368
C2H2 Zn finger 192..213 CDD:275370
C2H2 Zn finger 221..239 CDD:275370
COG5048 <443..730 CDD:227381 100/304 (33%)
C2H2 Zn finger 476..496 CDD:275368 6/19 (32%)
zf-H2C2_2 488..513 CDD:290200 10/24 (42%)
C2H2 Zn finger 504..525 CDD:275368 8/20 (40%)
C2H2 Zn finger 532..548 CDD:275368 3/15 (20%)
C2H2 Zn finger 573..593 CDD:275368 7/19 (37%)
C2H2 Zn finger 600..620 CDD:275368 7/19 (37%)
zf-H2C2_2 613..637 CDD:290200 8/23 (35%)
C2H2 Zn finger 628..648 CDD:275368 7/19 (37%)
zf-H2C2_2 640..663 CDD:290200 11/22 (50%)
C2H2 Zn finger 656..676 CDD:275368 6/19 (32%)
C2H2 Zn finger 684..704 CDD:275368 9/19 (47%)
zf-C2H2 684..704 CDD:278523 9/19 (47%)
zf-H2C2_2 696..721 CDD:290200 13/24 (54%)
C2H2 Zn finger 712..732 CDD:275368 10/47 (21%)
C2H2 Zn finger 739..755 CDD:275368 5/15 (33%)
ZBTB17NP_001274532.1 BTB 14..109 CDD:279045
BTB 25..109 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..295 50/236 (21%)
Interaction with MYC 269..308 12/47 (26%)
COG5048 306..637 CDD:227381 107/331 (32%)
zf-C2H2 306..328 CDD:278523 6/21 (29%)
C2H2 Zn finger 308..328 CDD:275368 6/19 (32%)
zf-H2C2_2 320..344 CDD:290200 9/23 (39%)
C2H2 Zn finger 336..356 CDD:275368 8/19 (42%)
C2H2 Zn finger 364..384 CDD:275368 5/20 (25%)
zf-C2H2 390..412 CDD:278523 2/21 (10%)
C2H2 Zn finger 392..412 CDD:275368 2/19 (11%)
zf-H2C2_2 404..428 CDD:290200 6/23 (26%)
C2H2 Zn finger 420..440 CDD:275368 7/19 (37%)
zf-C2H2 446..468 CDD:278523 7/21 (33%)
C2H2 Zn finger 448..468 CDD:275368 7/19 (37%)
zf-C2H2 475..496 CDD:278523 7/20 (35%)
C2H2 Zn finger 476..496 CDD:275368 7/19 (37%)
zf-H2C2_2 488..512 CDD:290200 11/23 (48%)
C2H2 Zn finger 504..524 CDD:275368 6/19 (32%)
zf-H2C2_2 516..541 CDD:290200 13/24 (54%)
C2H2 Zn finger 532..552 CDD:275368 9/19 (47%)
zf-H2C2_2 544..569 CDD:290200 13/24 (54%)
C2H2 Zn finger 560..580 CDD:275368 10/19 (53%)
zf-H2C2_2 573..597 CDD:290200 4/23 (17%)
C2H2 Zn finger 588..608 CDD:275368 0/19 (0%)
zf-H2C2_2 600..625 CDD:290200 8/24 (33%)
C2H2 Zn finger 616..635 CDD:275370 6/18 (33%)
C2H2 Zn finger 726..746 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 786..810
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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