DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and ZNF69

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	351	Identity:	116/351 - (33%)
Similarity:	170/351 - (48%)	Gaps:	48/351 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   440 FRLKQEPLDGEKPLKKAKSG----------RRRRRRNKDEPNPDNRCEVCQRTFSRHC---HLLR 491
            ||..|....||||....:.|          |.....:.|.|   .:|:.|.:.|  ||   :|:
Human   182 FRTPQRDHTGEKPYACKECGKTFISHSSIQRHVVMHSGDGP---YKCKFCGKAF--HCLSLYLI- 240

  Fly   492 HKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGE 556
            |:..|..:||:.|..|.|:|:.|..|:.|.::....|.::|..|..||.......||: ..|.||
Human   241 HERIHTGEKPYECKQCGKSFSYSATLRIHERTHTGEKPYECQQCGKAFHSPRCYRRHE-RIHTGE 304

  Fly   557 GLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREHEKTH 620
                        ..:.|:.|.|.|:...|:|.|...|: ...|.|..|.:........:.|.:.|
Human   305 ------------KAYQCKECGKAFTCPQYVRIHERTHSRKKPYECTQCGKALSSLTSFQTHIRMH 357

  Fly   621 TGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNLCN 685
            :|:|.:.|.|||..|...:..:.|.:.|:|||||||:.|.|||..::.|:.|||.|||.||..|.
Human   358 SGERPYECKICGKGFCSANSFQRHEKTHSGEKPYKCKQCGKAFIHSSSLRYHERIHTGEKPYECK 422

  Fly   686 TCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKA------HIRRHTGER-YKCPHCD 743
            .|||:|..:.:|.:|.||||||:||:|.:|.|:|....:|::      |:|.|:||| |||..|.
Human   423 QCGKAFRSSSHLQLHGRTHTGEKPYECQECGKAFRSMKNLQSHERTQTHVRIHSGERPYKCKLCG 487

  Fly   744 AYFLQLYNMRNHCMSAHNKHIETKTG 769
            ..|        :|..:..:|.:|.||
Human   488 KGF--------YCPKSLQRHEKTHTG 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	99/306 (32%)
		C2H2 Zn finger	476..496	CDD:275368	7/22 (32%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	4/15 (27%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	3/19 (16%)
		zf-H2C2_2	613..637	CDD:290200	9/23 (39%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	11/22 (50%)
		C2H2 Zn finger	656..676	CDD:275368	9/19 (47%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
		zf-C2H2	684..704	CDD:278523	8/19 (42%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	7/25 (28%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..189	CDD:275368	3/6 (50%)
		C2H2 Zn finger	197..217	CDD:275368	2/19 (11%)
		COG5048	222..>540	CDD:227381	106/311 (34%)
		C2H2 Zn finger	225..245	CDD:275368	7/22 (32%)
		zf-H2C2_2	241..262	CDD:290200	8/20 (40%)
		C2H2 Zn finger	253..273	CDD:275368	7/19 (37%)
		zf-H2C2_2	266..290	CDD:290200	7/23 (30%)
		C2H2 Zn finger	281..301	CDD:275368	6/20 (30%)
		zf-H2C2_2	295..318	CDD:290200	9/35 (26%)
		C2H2 Zn finger	309..329	CDD:275368	7/19 (37%)
		C2H2 Zn finger	337..357	CDD:275368	3/19 (16%)
		zf-H2C2_2	349..372	CDD:290200	8/22 (36%)
		C2H2 Zn finger	365..385	CDD:275368	6/19 (32%)
		zf-H2C2_2	377..400	CDD:290200	11/22 (50%)
		C2H2 Zn finger	393..413	CDD:275368	9/19 (47%)
		zf-H2C2_2	405..430	CDD:290200	14/24 (58%)
		C2H2 Zn finger	421..441	CDD:275368	8/19 (42%)
		C2H2 Zn finger	449..468	CDD:275368	5/18 (28%)
		C2H2 Zn finger	483..503	CDD:275368	5/27 (19%)
		zf-H2C2_2	495..520	CDD:290200	4/11 (36%)
		C2H2 Zn finger	511..531	CDD:275368
		zf-H2C2_2	523..546	CDD:290200
		C2H2 Zn finger	539..559	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000