DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and ZSCAN20

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001364305.1	Gene:	ZSCAN20 / 7579	HGNCID:	13093	Length:	1043	Species:	Homo sapiens

Alignment Length:	871	Identity:	215/871 - (24%)
Similarity:	323/871 - (37%)	Gaps:	259/871 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EPAVSKLVSQLEPLTTMDTVDAERVCRVCLKDVSLEGELHFIFNETPV----------------- 68
            |||        :.||..|:...|...:..::|:.:.| :|:.:.||..
Human   295 EPA--------QALTWRDSRAWEEQYQWDVEDMKVSG-VHWGYEETKTFLAILSESPFSEKLRTC 350

  Fly    69 EQDANLARILDE--------CTLHQCE-------RN-----DGMPPHMCS-----SCVEAARNAY 108
            .|:..:.|.:.|        .||.||.       ||     ...||..|.     ..:..||.|.
Human   351 HQNRQVYRAIAEQLRARGFLRTLEQCRYRVKNLLRNYRKAKSSHPPGTCPFYEELEALVRARTAI 415

  Fly   109 RFKRHAERSYCSLVALLGRSPQLKARGAEAASQTDQVALLPCEM---CHDQFLNSLELRLHRNQV 170
            |    |.......|||    |:|....||...| ::....|.||   |:...|.::|
Human   416 R----ATDGPGEAVAL----PRLGYSDAEMDEQ-EEGGWDPEEMAEDCNGAGLVNVE-------- 463

  Fly   171 HRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQ--TARLQCAH----CQRTFS 229
              :|:....||...|    |:.:....|:.: .:.::.||...|.  :.:|:..|    ..|..:
Human   464 --STQGPRIAGAPAL----FQSRIAGVHWGY-EETKAFLAILSESPFSEKLRTCHQNSQVYRAIA 521

  Fly   230 RRDHLLRHIR--NQHRDVEEDLLRTWPPADENTMNSDGG-------DELVSAEVLLNEEDNEDEV 285
            .|...|..:|  .|.|...::|||::..|  .:.:..|.       |.|:.|...:.......|.
Human   522 ERLCALGFLRTLEQCRYRFKNLLRSYRKA--KSSHPPGTCPFYEELDSLMRARAAVRAMGTVREA 584

  Fly   286 VGEAFQCNTNPISSNEDDGEEANG--ANQTLWLHIKPEP-CLEAEEVDLAMQLKLEKKRRRREKA 347
            .|.. :|..   ||.|.|.:||.|  ||:..   :||.. |.:|.::...|:
Human   585 AGLP-RCGQ---SSAETDAQEAWGEVANEDA---VKPSTLCPKAPDMGFEMR------------- 629

  Fly   348 EAQAETSIDRTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDG 412
                                              .:||..:..:|..: .:.|.|.....|....
Human   630 ----------------------------------HEDEDQISEQDIFE-GLPGALSKCPTEAVCQ 659

  Fly   413 FADDDSDLDDDDDDDDE---------EDAGDDDDGEFRLKQEPLD-GEKPLKKAKSGRRRRRRNK 467
            ..|...|.:::::|:.:         :::..::|.|..:..:.|. .|||.|
Human   660 PLDWGEDSENENEDEGQWGNPSQEQWQESSSEEDLEKLIDHQGLYLAEKPYK------------- 711

  Fly   468 DEPNPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHS-NKEHK 531
                    |:.|.::|||..|.:.|:..|..:||:.|..|.|.|:...:|..| |.:|: .|.:|
Human   712 --------CDTCMKSFSRSSHFIAHQRIHTGEKPYKCLECGKNFSDRSNLNTH-QRIHTGEKPYK 767

  Fly   532 CSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-- 594
            |..|..:||....|..|: ..|.||  :|          :.|..|.|.|:..:.|.||..:|.
Human   768 CLECGKSFSDHSNLITHQ-RIHTGE--KP----------YKCGECWKSFNQSSNLLKHQRIHLGG 819

  Fly   595 ----------------------------------------------------DFLYACKTCDETF 607
                                                                :.||.|..|..:|
Human   820 NPDQCSEPGGNFAQSPSFSAHWRNSTEETAPEQPQSISKDLNSPGPHSTNSGEKLYECSECGRSF 884

  Fly   608 RERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVH 672
            .:.:.|..|::.|||::.:.|..||.||:::..|..|.|.|.|||||||..|.|.|...:.|..|
Human   885 SKSSALISHQRIHTGEKPYECAECGKSFSKSSTLANHQRTHTGEKPYKCVDCGKCFSERSKLITH 949

  Fly   673 ERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER- 736
            :|.|||.||..|..|||.|....||..|.|.||||:||||.:|.|.|.||:.|..|.|.||||:
Human   950 QRVHTGEKPYKCLECGKFFRDRSNLITHQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIHTGEKP 1014

  Fly   737 YKCPHCDAYFLQLYNMRNHCMSAHNK 762
            |||..|...|    |..:| .|||.:
Human  1015 YKCTECGKDF----NNSSH-FSAHRR 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	22/117 (19%)
		C2H2 Zn finger	150..171	CDD:275368	5/23 (22%)
		C2H2 Zn finger	192..213	CDD:275370	3/20 (15%)
		C2H2 Zn finger	221..239	CDD:275370	4/21 (19%)
		COG5048	<443..730	CDD:227381	104/342 (30%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..637	CDD:290200	10/23 (43%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	13/22 (59%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		C2H2 Zn finger	684..704	CDD:275368	9/19 (47%)
		zf-C2H2	684..704	CDD:278523	9/19 (47%)
		zf-H2C2_2	696..721	CDD:290200	15/24 (63%)
		C2H2 Zn finger	712..732	CDD:275368	9/19 (47%)
		C2H2 Zn finger	739..755	CDD:275368	4/15 (27%)
ZSCAN20	NP_001364305.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..49
		SCAN	47..132	CDD:396558
		Myb_DNA-bind_4	323..404	CDD:404682	16/81 (20%)
		Myb_DNA-bind_4	483..564	CDD:404682	17/83 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	661..692		3/30 (10%)
		COG5048	699..>1029	CDD:227381	115/368 (31%)
		C2H2 Zn finger	712..732	CDD:275368	7/19 (37%)
		C2H2 Zn finger	740..760	CDD:275368	7/20 (35%)
		C2H2 Zn finger	768..788	CDD:275368	6/20 (30%)
		C2H2 Zn finger	796..816	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..873		0/37 (0%)
		C2H2 Zn finger	877..897	CDD:275368	5/19 (26%)
		C2H2 Zn finger	905..925	CDD:275368	8/19 (42%)
		C2H2 Zn finger	933..953	CDD:275368	7/19 (37%)
		C2H2 Zn finger	961..981	CDD:275368	9/19 (47%)
		C2H2 Zn finger	989..1009	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1017..1037	CDD:275368	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000