DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and ZNF3

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001305065.1	Gene:	ZNF3 / 7551	HGNCID:	13089	Length:	453	Species:	Homo sapiens

Alignment Length:	573	Identity:	141/573 - (24%)
Similarity:	219/573 - (38%)	Gaps:	185/573 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 LPSEDFKCKFCP---------QHFPHLRQLRSHLARSHEQTARLQCAHC--QRTFSRRDHLLRHI 238
            |||:  .|.|.|         .|.||               ..:.|.|.  |...:..|..:..|
Human    21 LPSQ--MCIFHPILSDFFGAAIHIPH---------------PEIACQHVLFQELVTFEDVAVYFI 68

  Fly   239 RNQHRDVE---EDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSN 300
            |.:.:.:|   .||.|                     :|:|       |..|..|..:....:.|
Human    69 RKEWKRLEPAQRDLYR---------------------DVML-------ENYGNVFSLDRETRTEN 105

  Fly   301 EDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIA 365
            :.:..|...::..|         |...:.|::..||.::...|        |.|:.|.:.|
Human   106 DQEISEDTRSHGVL---------LGRFQKDISQGLKFKEAYER--------EVSLKRPLGN---- 149

  Fly   366 IGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDE--ERFDGFADD---DSDLDDDDD 425
                           ...:.....:.||.::.|..:|....|  |:::.|.:.   :|:|
Human   150 ---------------SPGERLNRKMPDFGQVTVEEKLTPRGERSEKYNDFGNSFTVNSNL----- 194

  Fly   426 DDDEEDAGDDDDGEFRLKQEPLD-GEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHL 489
                            :..:.|. |::|                     ::|:.|.::|:|...|
Human   195 ----------------ISHQRLPVGDRP---------------------HKCDECSKSFNRTSDL 222

  Fly   490 LRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHN 554
            ::|:..|..:||:.|..|.|||::|.||..| |.:|:
Human   223 IQHQRIHTGEKPYECNECGKAFSQSSHLIQH-QRIHT---------------------------- 258

  Fly   555 GEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREHEK 618
              |.:|          :.|..|.|.||..:.|..|..:|| :..|.|..|.:||...:.|..|::
Human   259 --GEKP----------YECSDCGKTFSCSSALILHRRIHTGEKPYECNECGKTFSWSSTLTHHQR 311

  Fly   619 THTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNL 683
            .|||::.:.|..||.:|:|:..|..|.|.|.|||||:|..|.|||.:::.|..|:|.|||.||..
Human   312 IHTGEKPYACNECGKAFSRSSTLIHHQRIHTGEKPYECNECGKAFSQSSHLYQHQRIHTGEKPYE 376

  Fly   684 CNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER 736
            |..||..|..:..|..|.|.||||.||:|.:|.|:|..|:.|..|.|.||||:
Human   377 CMECGGKFTYSSGLIQHQRIHTGENPYECSECGKAFRYSSALVRHQRIHTGEK 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370	6/29 (21%)
		C2H2 Zn finger	221..239	CDD:275370	4/19 (21%)
		COG5048	<443..730	CDD:227381	91/288 (32%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	488..513	CDD:290200	10/24 (42%)
		C2H2 Zn finger	504..525	CDD:275368	10/20 (50%)
		C2H2 Zn finger	532..548	CDD:275368	0/15 (0%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	9/23 (39%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	12/22 (55%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	13/24 (54%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368
ZNF3	NP_001305065.1	KRAB	57..98	CDD:366587	12/68 (18%)
		COG5048	<182..360	CDD:227381	66/260 (25%)
		C2H2 Zn finger	185..201	CDD:275368	2/36 (6%)
		C2H2 Zn finger	209..229	CDD:275368	6/19 (32%)
		C2H2 Zn finger	237..257	CDD:275368	10/20 (50%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	6/19 (32%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		zf-H2C2_2	361..386	CDD:372612	12/24 (50%)
		C2H2 Zn finger	377..397	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..414	CDD:372612	13/23 (57%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000