Protein Alignment CG2202 and ZBTB4

DIOPT Version :10

• Sequence 1: NP_572657.2
• Gene: CG2202 / 32014
• FlyBaseID: FBgn0030240
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: NP_065950.2
• Gene: ZBTB4 / 57659
• HGNCID: 23847
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 459
• Identity: 101/459 - (22%)
• Similarity: 146/459 - (31%)
• Gaps: 155/459 - (33%)

  Fly   472 PDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCE 536
            ||.:|.                   |.::|..||.|.|:|.....|:.|        |.:|
Human   223 PDLQCS-------------------LPRRPLPCPQCGKSFIHPKRLQTH--------EAQC---- 256

  Fly   537 AAFSRLDALERHKVSKHNGEGLEPGSELKLQLA------------EHTCEYCSKRFSSKTYLRKH 589
                |..|..|.......| |..||....:..:            ||..:
Human   257 ----RRGASTRGSTGLGAG-GAGPGGPAGVDASALPPPVGFRGGPEHVVK--------------- 301

  Fly   590 TLLHTDFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPY 654
             ::....||.|..|:.::...:.|:.|...|:.:|.:.|..|...||..:|...|...|.||:.|
Human   302 -VVGGHVLYVCAACERSYVTLSSLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRY 365

  Fly   655 KCRFCVKAFPRATDLKVHERYHTGTKPNL--------------CNTCGKSFHRAYNLTIHMRTHT 705
            :|.||.:.|....:||.|:|...|..|.|              .||.     :.|.| :.||  .
Human   366 QCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLNTL-----KLYRL-LPMR--A 422

  Fly   706 GERPYK-----CDQCPKSFTQSNDLKAHIRRH-------TGERYKCPHCDAYFLQLYNMRNHCMS 758
            .:||||     ..:.|.|.|.:......:...       ..|....|....:
Human   423 AKRPYKTYSQGAPEAPLSPTLNTPAPVAMPASPPPGPPPAPEPGPPPSVITF------------- 474

  Fly   759 AHNK-----HIETKTGRLQRTGLLDDGGQ--SHLTTVVMPPARYPNELD-----PQLAAT----- 806
            ||..     |..:.:|. ..:|....||.  :.:.|...|| |.|.:.:     |:.|||
Human   475 AHPAPSVIVHGGSSSGG-GGSGTASTGGSQAASVITYTAPP-RPPKKREYPPPPPEPAATPTSPA 537

  Fly   807 ---AAATAAGGAESTSSTTVIHSPG---------TYNAT-------AAAPANTFDGANFTPTAVN 852
               :.|||||.|   .:||...:.|         ||.|.       ...|..   ||...|:.:.
Human   538 TAVSPATAAGPA---MATTTEEAKGRNPRAGRTLTYTAKPVGGIGGGGGPPT---GAGRGPSQLQ 596

  Fly   853 TPAP 856
            .|.|
Human   597 APPP 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:214871
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	65/288 (23%)
		C2H2 Zn finger	476..496	CDD:275368	1/19 (5%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	3/15 (20%)
		C2H2 Zn finger	573..593	CDD:275368	0/19 (0%)
		C2H2 Zn finger	600..620	CDD:275368	4/19 (21%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		C2H2 Zn finger	712..732	CDD:275368	3/19 (16%)
		C2H2 Zn finger	739..755	CDD:275368	1/15 (7%)
ZBTB4	NP_065950.2	BTB_POZ	12..181	CDD:453885
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..124
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..221
		Interaction with CBFA2T3. /evidence=ECO:0000269|PubMed:23251453	186..348		34/176 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..281		7/24 (29%)
		C2H2 Zn finger	311..331	CDD:275368	4/19 (21%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..385	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..765		40/194 (21%)
		C2H2 Zn finger	728..748	CDD:275368
		zf-C2H2	765..787	CDD:395048
		C2H2 Zn finger	767..787	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..852
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1013