DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and Insm1

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_058585.2	Gene:	Insm1 / 53626	MGIID:	1859980	Length:	521	Species:	Mus musculus

Alignment Length:	293	Identity:	65/293 - (22%)
Similarity:	107/293 - (36%)	Gaps:	73/293 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   441 RLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCP 505
            ::|:.|:  |.|..:|....|        |..:..|::|:..::....|.:||.|.:.:..:.||
Mouse   249 KIKEGPV--EAPRGRAGGATR--------PLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCP 303

  Fly   506 HCPKAFARSDHLKAHVQSLHSNKEHKCSLCEA--------AFSRLDALERHKVSKHNGEGLEPG- 561
            .|.|.|:...:|.:|      .:.||.....|        |.:|.:|.|.......:.:...||
Mouse   304 ECAKVFSCPANLASH------RRWHKPRPVPAAARAPEPEAATRAEAREAAGGGSSDRDTPSPGG 362

  Fly   562 -SELKLQLAEHTCEYCSKRFSSKTYLRKHTLLH--------------------TDFLYACKTCDE 605
             ||...:...:.|.:|:|:|..:.|||||.|.|                    .|.|......||
Mouse   363 VSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPPPPPPPPPPAEDILAFYAGPDE 427

  Fly   606 TFRERAQ----------LREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCV 660
            ...:.|.          |....:.|      ||.:||::|........|:|..:..:.:.|::|.
Mouse   428 KAPQEASGDGEAAGVLGLSATAQCH------LCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCP 486

  Fly   661 KAFPRATDLKVHERYHTGTKPNLCNTCGKSFHR 693
            ..|..:..|..|           .|.|..|.:|
Mouse   487 ATFYSSPGLTRH-----------INKCHPSENR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	65/291 (22%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	5/23 (22%)
		C2H2 Zn finger	573..593	CDD:275368	10/19 (53%)
		C2H2 Zn finger	600..620	CDD:275368	4/29 (14%)
		zf-H2C2_2	613..637	CDD:290200	7/23 (30%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	4/22 (18%)
		C2H2 Zn finger	656..676	CDD:275368	5/19 (26%)
		C2H2 Zn finger	684..704	CDD:275368	4/10 (40%)
		zf-C2H2	684..704	CDD:278523	4/10 (40%)
		zf-H2C2_2	696..721	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	739..755	CDD:275368
Insm1	NP_058585.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		SNAG domain. /evidence=ECO:0000305\|PubMed:24227653	1..20
		Required and sufficient for interaction with KDM1A. /evidence=ECO:0000250\|UniProtKB:Q01101	2..7
		Necessary for interaction with CCND1. /evidence=ECO:0000250	43..56
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	180..230
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		C2H2 Zn finger	302..322	CDD:275368	7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..369		11/48 (23%)
		zf-C2H2	373..395	CDD:278523	10/21 (48%)
		C2H2 Zn finger	375..395	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..419		1/20 (5%)
		C2H2 Zn finger	454..475	CDD:275368	6/20 (30%)
		C2H2 Zn finger	482..503	CDD:275368	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910