DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CG4936

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	742	Identity:	156/742 - (21%)
Similarity:	237/742 - (31%)	Gaps:	304/742 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VCRVCLKDVSLEGELHFIFNETPVEQDANLARILDECTLHQCERNDGMPPHMCSSCVEAARNAYR 109
            ||||||:..  :..:..|||:   :.:.:|..::.||.....::.|..|..:|..|.:..:.|::
  Fly    22 VCRVCLQQP--KEPMASIFND---DSEKDLTHMIRECGGVPIKQFDHYPDKICEKCFKVLKMAFK 81

  Fly   110 FKRHAERSYCSLVALLG------RSPQLKARGAEAASQTDQVALLPCEMCHDQFLNSLELRLHRN 168
            |:...:|||..|...:|      |.|:.|  |:|.|::.:.
  Fly    82 FRETCQRSYGHLRQFVGPVEVEQRPPEKK--GSETATKLEP------------------------ 120

  Fly   169 QVHRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQTARLQCAHCQRTFSRRDH 233

  Fly   121 ----------------------------------------------------------------- 120

  Fly   234 LLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPIS 298
                      ||:.|.....|..||.       ||         :.|.::....||
  Fly   121 ----------DVDPDEAEQEPEHDEE-------DE---------DVDLDESHYAEA--------- 150

  Fly   299 SNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRT--VKN 361
               ||..|..|.             :..:|::..:.::|||                ||.  |||
  Fly   151 ---DDAAETQGG-------------VFHDEIEDGILVELEK----------------DRIVHVKN 183

  Fly   362 EHI---AIGDSQFSIKE--ENQLV---GSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDS 418
            |.:   .|.:..:.:.|  |..|:   |.|.|    :.|.....:|.|:...|:      .:.|.
  Fly   184 EQVEEDGIIEEVYDVYETYEGDLIPDQGYDHE----MADQALSELSAEIEYLDQ------VEHDQ 238

  Fly   419 DLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTF 483
            ..:...:||.|.|....:: ||          .|.|..::....|...|...||
  Fly   239 LTESAHEDDAEVDLNSTEE-EF----------VPSKSVRASIHARNATKRRVNP----------- 281

  Fly   484 SRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSR-LDALER 547
                                        .||....|.|            ..|::.|: .|....
  Fly   282 ----------------------------RRSATSTASV------------AVESSTSKTTDRGNP 306

  Fly   548 HKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFS-SKTYLRKHTLLHT------------DFLYA 599
            .||.:.|.:  ..||::.::        ..|..| .:...|||:.:.|            :|.|.
  Fly   307 LKVRRGNSD--SAGSKMSIK--------SEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYI 361

  Fly   600 CKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFP 664
            |..|...:..:::|.||.|.|:|.:...|.|||..||:...|..||..|.|.:||||.:|..||
  Fly   362 CDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAF- 425

  Fly   665 RATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHI 729
              .||....::|                         |.||.||||:||.|.|:||.:|.||.|.
  Fly   426 --ADLSTRNKHH-------------------------RIHTNERPYECDVCHKTFTYTNTLKFHK 463

  Fly   730 RRHTGER-YKCPHCDAYFLQLYNMRNH 755
            ..||||: :.|..|...|.|.|.:|||
  Fly   464 MIHTGEKPHVCDVCGKGFPQAYKLRNH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	21/75 (28%)
		C2H2 Zn finger	150..171	CDD:275368	0/20 (0%)
		C2H2 Zn finger	192..213	CDD:275370	0/20 (0%)
		C2H2 Zn finger	221..239	CDD:275370	0/17 (0%)
		COG5048	<443..730	CDD:227381	72/300 (24%)
		C2H2 Zn finger	476..496	CDD:275368	0/19 (0%)
		zf-H2C2_2	488..513	CDD:290200	0/24 (0%)
		C2H2 Zn finger	504..525	CDD:275368	4/20 (20%)
		C2H2 Zn finger	532..548	CDD:275368	3/16 (19%)
		C2H2 Zn finger	573..593	CDD:275368	5/20 (25%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	11/23 (48%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..663	CDD:290200	10/22 (45%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	1/19 (5%)
		zf-C2H2	684..704	CDD:278523	1/19 (5%)
		zf-H2C2_2	696..721	CDD:290200	12/24 (50%)
		C2H2 Zn finger	712..732	CDD:275368	10/19 (53%)
		C2H2 Zn finger	739..755	CDD:275368	6/15 (40%)
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	22/77 (29%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	28/88 (32%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		zf-H2C2_2	403..426	CDD:290200	12/25 (48%)
		C2H2 Zn finger	418..438	CDD:275368	8/47 (17%)
		zf-H2C2_2	432..455	CDD:290200	13/47 (28%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		zf-H2C2_2	459..481	CDD:290200	9/21 (43%)
		C2H2 Zn finger	474..494	CDD:275368	8/17 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457870
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930