DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CG5245

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_650197.1	Gene:	CG5245 / 41530	FlyBaseID:	FBgn0038047	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	593	Identity:	153/593 - (25%)
Similarity:	219/593 - (36%)	Gaps:	205/593 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 SEDFKCKFCPQHFPHLRQLRSHLARSHEQTARLQCAHCQRTFSRRD----HLLRHIRNQHRDVEE 247
            ::.|||..|.:.|.....|.||| |.|.:....:|:||.::|.||.    |||:|.:..|:.  .
  Fly    79 TDTFKCTQCQKTFTRKENLESHL-RLHAEERPFECSHCSKSFGRRTHYKRHLLKHEKRPHKC--S 140

  Fly   248 DLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSNEDDGEEANGANQ 312
            ...:|:      |.||       |.:..|:|...|     ..|:|
  Fly   141 HCSKTF------TQNS-------SLKQHLHEHTGE-----RPFKC-------------------- 167

  Fly   313 TLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIAIGDSQFSIKEEN 377
                                                .|..||..|
  Fly   168 ------------------------------------TQCSTSFAR-------------------- 176

  Fly   378 QLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLDDDDDDDDEEDAGDDDDGEFRL 442
                             |.|:...|....|||
  Fly   177 -----------------KSHLQVHLRTHSEER--------------------------------- 191

  Fly   443 KQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHC 507
               |.:                           |..|::.|..:.||..|..:|.|.:|..|.||
  Fly   192 ---PFE---------------------------CTHCEKAFKNNSHLQEHLRTHQEARPFKCSHC 226

  Fly   508 PKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEP------------ 560
            .|:|.....|:.|:.: |:.:..||:.|...|.:.|:|:.| :..|.||  :|
  Fly   227 SKSFKLRSILQKHLLT-HAERSFKCTQCPKTFLQNDSLQIH-LRVHAGE--DPFKCPHCSETFAR 287

  Fly   561 GSELKLQLAEHT------CEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREHEK 618
            .|.|:|.|.||.      |..||..|:.::..|.|..||| :..|.|..|.::|.:::.|.||::
  Fly   288 NSRLQLHLLEHAGKEPLKCSQCSATFAMRSLYRVHVRLHTRERQYKCAECSKSFFKKSHLVEHQQ 352

  Fly   619 THTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNL 683
            .|||:|.|.|..|...|....:|||||..|.|||..||.:|.|.|..::.|.||.:.|||.....
  Fly   353 VHTGERPFKCTHCFKDFKCRTHLRVHMLDHIGEKVPKCSYCSKEFKLSSQLLVHLQEHTGKNQFE 417

  Fly   684 CNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER-YKCPHCDAYFL 747
            |..|.||:..:..|.:|:||||||.|:||..|.|.|.:|.:.:.|:|.||||: |||.||...:.
  Fly   418 CPHCSKSYTTSSTLHMHLRTHTGELPFKCSHCSKLFARSAEHQEHLRTHTGEKPYKCSHCSTRYT 482

  Fly   748 QLYNMRNH 755
            |..::..|
  Fly   483 QKSSLGRH 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370	8/20 (40%)
		C2H2 Zn finger	221..239	CDD:275370	10/21 (48%)
		COG5048	<443..730	CDD:227381	99/305 (32%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	488..513	CDD:290200	11/24 (46%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	11/23 (48%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	13/22 (59%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..755	CDD:275368	4/15 (27%)
CG5245	NP_650197.1	COG5048	74..478	CDD:227381	150/579 (26%)
		C2H2 Zn finger	84..104	CDD:275368	8/20 (40%)
		C2H2 Zn finger	112..132	CDD:275368	9/19 (47%)
		C2H2 Zn finger	139..159	CDD:275368	6/34 (18%)
		C2H2 Zn finger	167..187	CDD:275368	8/112 (7%)
		zf-H2C2_2	179..204	CDD:290200	9/87 (10%)
		C2H2 Zn finger	195..215	CDD:275368	6/19 (32%)
		C2H2 Zn finger	223..243	CDD:275368	7/20 (35%)
		C2H2 Zn finger	250..270	CDD:275368	6/20 (30%)
		C2H2 Zn finger	278..298	CDD:275368	4/19 (21%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	6/19 (32%)
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		C2H2 Zn finger	474..492	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.970