DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CG6689

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	624	Identity:	137/624 - (21%)
Similarity:	236/624 - (37%)	Gaps:	167/624 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 GLPSEDFKCK---FCPQHFPH---LRQLRSHLARSHEQTARLQCAHC----QRTFSRRDHLLRHI 238
            |...|..|.|   .|.:||..   ...|:..:..:.::|.|.....|    |.:.|.|....|..
  Fly    46 GYTEESLKLKNPCICIEHFKDEDIEGSLKFEMGLAKKRTLRPGAVPCVNKSQESGSDRARKERSQ 110

  Fly   239 RNQHRDVEEDLLRTWPPADENT------MNSDGGDELVSAEVLLNEED--NEDEVVGEAFQCNT- 294
            |.:::::..:||     |:|..      ..|...|.:..:|.:..|.|  :.:|.:.|..:|.|
  Fly   111 RRRNQELVAELL-----AEEEAKLIHPEATSFEQDSVYLSETVTMELDPLSGEEKLEELQKCRTC 170

  Fly   295 -NPISSNEDDGEEANGANQTLWLHI----------KP-EP-------------CLEAEEVDLAMQ 334
             |..:::....:..:.||..|..||          || ||             .::..|:.::.:
  Fly   171 YNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPRLMCPACKSALDQAIDFREMCISTE 235

  Fly   335 LKLEKKRRRREKAEAQAETSIDRTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVS 399
            |||.:.:...::.:.:||.  :..:.::|..|.|::.:..||.:..|.|             ||.
  Fly   236 LKLSQAKPSTDEVQIEAEN--ENPISSDHDLISDTENTNVEEIEDAGGD-------------HVE 285

  Fly   400 GELPLSDEERFDGFADDDSDLDDDDDDDDEEDAGDD---------------------DDGEFRLK 443
            .|.           ..||....:..|:..|..|..|                     :....| |
  Fly   286 DEA-----------TSDDQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKARLR-K 338

  Fly   444 QEPLDGEKPLKKAKSGRRRRRRN-----KDEPN-----------PDNRCEVCQRTFSRHCHLLR- 491
            ..|:..:...|:..:|.::.:|:     |:|.|           |:..|:.|.:.| |..|.||
  Fly   339 GAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAF-RMSHNLRI 402

  Fly   492 HKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHK------CSLCEAAFSRLDALERHKV 550
            |.|.|...|.:.|..|||.|     ..|:::::|....|:      |..|...|:...|.::|:.
  Fly   403 HMLRHTRTKNYQCTECPKTF-----YDAYMRNMHIRIRHRGETPFACGFCSETFAYPGARQKHES 462

  Fly   551 SKHNG------EGLEPGSELK-LQLAEHTCEYCSKRFSSKTYLRKHTLLHTDF-LYACKTCDETF 607
            ..||.      :.:.|....| .:...:.|:.|.|.::||..|..|...|||. .|.|:.|.:::
  Fly   463 EVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKYALGWHIKSHTDANAYKCQRCSKSY 527

  Fly   608 RERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVH 672
            .:..:|:.||.||.                             ::|.:|..|:|.|.:.|.|:.|
  Fly   528 SDPNKLKRHEMTHE-----------------------------KRPLQCDVCLKGFYQRTRLREH 563

  Fly   673 ERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYK 711
            |..|||.:|..|..|..:|...||    |::|...:.::
  Fly   564 ELIHTGERPYWCEVCNVNFRYKYN----MKSHANSKMHQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370	5/26 (19%)
		C2H2 Zn finger	221..239	CDD:275370	5/21 (24%)
		COG5048	<443..730	CDD:227381	75/300 (25%)
		C2H2 Zn finger	476..496	CDD:275368	9/20 (45%)
		zf-H2C2_2	488..513	CDD:290200	12/25 (48%)
		C2H2 Zn finger	504..525	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..548	CDD:275368	4/15 (27%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..637	CDD:290200	5/23 (22%)
		C2H2 Zn finger	628..648	CDD:275368	0/19 (0%)
		zf-H2C2_2	640..663	CDD:290200	4/22 (18%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		zf-C2H2	684..704	CDD:278523	6/19 (32%)
		zf-H2C2_2	696..721	CDD:290200	3/16 (19%)
		C2H2 Zn finger	712..732	CDD:275368	137/624 (22%)
		C2H2 Zn finger	739..755	CDD:275368
CG6689	NP_650051.1	THAP	2..96	CDD:283206	11/49 (22%)
		zf-AD	167..240	CDD:214871	16/72 (22%)
		zf-C2H2	385..407	CDD:278523	9/22 (41%)
		C2H2 Zn finger	387..407	CDD:275368	9/20 (45%)
		zf-H2C2_2	399..422	CDD:290200	10/22 (45%)
		C2H2 Zn finger	415..436	CDD:275368	7/25 (28%)
		C2H2 Zn finger	444..460	CDD:275368	4/15 (27%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	8/19 (42%)
		zf-met	574..597	CDD:289631	7/26 (27%)
		C2H2 Zn finger	575..591	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457869
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840