DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and insm1a

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_991207.1	Gene:	insm1a / 402941	ZFINID:	ZDB-GENE-040426-1810	Length:	383	Species:	Danio rerio

Alignment Length:	436	Identity:	95/436 - (21%)
Similarity:	158/436 - (36%)	Gaps:	106/436 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   277 NEEDNEDEVVGEAFQCNTNPISSNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKR 341
            :|||.:...|.:...|...|:|                     |......|.|..||........
Zfish    22 SEEDEQGAFVAQDVPCARRPVS---------------------PVQFGNPETVYRAMYSPTRPVS 65

  Fly   342 RRREKAEAQAETSIDRTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSG------ 400
            |..|:|..:...::...:..|......:            ..|:||:.    :|:..|.
Zfish    66 REHERACLERRFNLGSPISAESFPAAPN------------CSDQAPVD----LKIGTSNSNRTGT 114

  Fly   401 ----ELPLSDEERFDGFADDDS----DLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAK 457
                :.|.||.||....|...:    .|..:|:.......|      .::|:.|:: :||..:..
Zfish   115 TVTTKRPASDTERKGKPASKKAKAMRKLQFEDEMTTSPVLG------LKIKEGPVE-QKPRSQCA 172

  Fly   458 SGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQ 522
            ||        |:|..:..|::|:..::....|.:||.|.:.:..:.||.|.|.|:...:|.:| :
Zfish   173 SG--------DKPLGEFVCQLCREAYADPFSLAQHKCSRIVRIEYRCPECDKLFSCPANLASH-R 228

  Fly   523 SLHSNKEHKCSLCEAAFSRLDALERHKVSKHN---GEGL-EPGSELKLQLAEHTCEYCSKRFSSK 583
            ..|..|:      .|..::..|.|:.:.|...   ..|| |.|||..|    :.|::|.|:|..:
Zfish   229 RWHKPKQ------SAESNKTPAPEKEETSSDRDTPSPGLSESGSEDGL----YDCQHCGKKFKRQ 283

  Fly   584 TYLRKHTLLHTDFLYACKTCDETFRERAQLR-EHEKTHTGQRNFLCCICGDSFARNDYLRVHMRR 647
            .||:||...|.|       ..|..:..|.|. ...:.|      ||.:||::|........|:|.
Zfish   284 AYLKKHVTAHHD-------APEKPQSHAPLNLSASECH------LCPVCGENFPSRMSQERHIRL 335

  Fly   648 HNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNLCNTCGKSFHR 693
            .:..:.|.|::|...|..:..|..|           .|.|..|.:|
Zfish   336 QHSAQVYPCKYCPAMFYSSPGLTRH-----------INKCHPSENR 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	65/256 (25%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		zf-H2C2_2	488..513	CDD:290200	9/24 (38%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	3/15 (20%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	600..620	CDD:275368	3/20 (15%)
		zf-H2C2_2	613..637	CDD:290200	7/24 (29%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	5/22 (23%)
		C2H2 Zn finger	656..676	CDD:275368	5/19 (26%)
		C2H2 Zn finger	684..704	CDD:275368	4/10 (40%)
		zf-C2H2	684..704	CDD:278523	4/10 (40%)
		zf-H2C2_2	696..721	CDD:290200
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	739..755	CDD:275368
insm1a	NP_991207.1	SNAG domain. /evidence=ECO:0000250\|UniProtKB:Q63ZV0	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	99..141		9/45 (20%)
		C2H2 Zn finger	183..203	CDD:275368	5/19 (26%)
		C2H2 Zn finger	211..231	CDD:275368	7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..269		12/45 (27%)
		zf-C2H2	271..293	CDD:278523	8/21 (38%)
		C2H2 Zn finger	273..293	CDD:275368	8/19 (42%)
		C2H2 Zn finger	316..335	CDD:275368	5/18 (28%)
		C2H2 Zn finger	344..365	CDD:275368	6/31 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910