DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and Meics

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_524062.1	Gene:	Meics / 39539	FlyBaseID:	FBgn0025874	Length:	583	Species:	Drosophila melanogaster

Alignment Length:	745	Identity:	171/745 - (22%)
Similarity:	270/745 - (36%)	Gaps:	243/745 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TVDAE--RVCRVCLKDVSLEGELHF-IFNETPVEQDANLARILDE-CTLHQCERNDGMPPHMCSS 99
            :|||.  :.||.|.:..|:..:|.. ..::.|:.:..|  .||.| |.:    :.|.||..:|.:
  Fly    12 SVDASMGKNCRACAEHSSILVDLFSKEISDPPIWEMLN--SILPEICRV----KRDEMPQKICPT 70

  Fly   100 CVEAARNAYRFKRHAERSYCSLVALLGRSPQLKARGAEAASQTDQVALLPCEMCHDQFLNSLELR 164
            |:.||:||:.|:...|:|:                                     ||.:.| |:
  Fly    71 CLVAAQNAFHFRHKCEQSF-------------------------------------QFFSQL-LQ 97

  Fly   165 LHRNQVHRTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQTARLQCAHCQRTFS 229
            |.::                                     .|:|:||          ||:|
  Fly    98 LDKS-------------------------------------NSNLSRS----------HCRR--- 112

  Fly   230 RRDHLLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNT 294
                                         .|||     .|:..|::..|:..:..|.  ....|.
  Fly   113 -----------------------------GTMN-----PLIPFEIVGCEDPLDTNVT--KLDANR 141

  Fly   295 NPISSNED---DGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSID 356
            ..:.::.|   ||:..||.        :.||..|..|:.:             ...:.:.|.||.
  Fly   142 PDVKTDIDEPTDGKATNGQ--------ESEPLQEVFEITM-------------NDIKTEDEVSIQ 185

  Fly   357 RTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGFADDDSDLD 421
            .|.::          :..|||                                      |:::.|
  Fly   186 ETFED----------AFDEEN--------------------------------------DNNNTD 202

  Fly   422 DDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEVCQRTFSRH 486
            .:.:|.|:...|..:           |.::|......||:....|    |....|..|..::|..
  Fly   203 SEREDSDQWTVGSTE-----------DQDEPWIPGGGGRQTVGGN----NQSLLCTECGVSYSTQ 252

  Fly   487 CHLLRHKLSHLE----KKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALER 547
            ..|.||...|.|    :|||.|..|.:.|..:..|..|.:.....:..||.||..|::....|:.
  Fly   253 KALARHVAKHKEQGDTQKPHLCDFCGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGPTLKS 317

  Fly   548 HKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERA 611
            |..:....:|             |.|..|.|.|.::..||.|...|| :..|.|..|.:||.:.:
  Fly   318 HMHTHDEEKG-------------HKCPQCDKTFYTRGNLRAHIQRHTGERPYKCPDCPQTFAKNS 369

  Fly   612 QLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYH 676
            .|:.|.:.|..:|.|.|.:||..|.:|.:|..|:|.|||::.:||..|.|:|...:::..|:|.|
  Fly   370 GLKLHSRLHKEERPFKCELCGKGFVQNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTH 434

  Fly   677 TGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER---YK 738
            :|.||..|..||::|...::|..|:|.||||:|||||||.|.|:.:..|..|...|....   :|
  Fly   435 SGIKPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKCDQCGKGFSANQSLMKHTLWHVDNNDRPFK 499

  Fly   739 CPHCDAYFLQLYNMRNHCMSAHNKHIETKT 768
            |..|...:....::|.| ...|....|.||
  Fly   500 CSQCPKAYDTQQSLRGH-EKTHKNPDEPKT 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	23/77 (30%)
		C2H2 Zn finger	150..171	CDD:275368	5/20 (25%)
		C2H2 Zn finger	192..213	CDD:275370	3/20 (15%)
		C2H2 Zn finger	221..239	CDD:275370	3/17 (18%)
		COG5048	<443..730	CDD:227381	94/291 (32%)
		C2H2 Zn finger	476..496	CDD:275368	6/19 (32%)
		zf-H2C2_2	488..513	CDD:290200	11/28 (39%)
		C2H2 Zn finger	504..525	CDD:275368	5/20 (25%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	9/23 (39%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	10/22 (45%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	16/24 (67%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
Meics	NP_524062.1	zf-AD	21..95	CDD:285071	25/116 (22%)
		C2H2 Zn finger	242..262	CDD:275368	6/19 (32%)
		C2H2 Zn finger	274..294	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	7/23 (30%)
		C2H2 Zn finger	302..322	CDD:275368	6/19 (32%)
		C2H2 Zn finger	330..350	CDD:275368	7/19 (37%)
		zf-H2C2_2	342..366	CDD:290200	9/23 (39%)
		C2H2 Zn finger	358..378	CDD:275368	6/19 (32%)
		C2H2 Zn finger	386..406	CDD:275368	8/19 (42%)
		COG5048	<395..583	CDD:227381	50/135 (37%)
		zf-C2H2	412..434	CDD:278523	7/21 (33%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		zf-H2C2_2	426..451	CDD:290200	10/24 (42%)
		C2H2 Zn finger	442..462	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	15/23 (65%)
		C2H2 Zn finger	470..486	CDD:275368	7/15 (47%)
		C2H2 Zn finger	500..520	CDD:275368	4/20 (20%)
		C2H2 Zn finger	532..552	CDD:275370
		C2H2 Zn finger	559..579	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D42822at6656
OrthoFinder	1	1.000	-	-		FOG0006715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.060