DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and prg

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001260253.1	Gene:	prg / 34177	FlyBaseID:	FBgn0285971	Length:	558	Species:	Drosophila melanogaster

Alignment Length:	537	Identity:	120/537 - (22%)
Similarity:	197/537 - (36%)	Gaps:	140/537 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 EDEVVGEAFQC--NTNPISSNEDDG-----EEANGA--NQTLW-LHIKPEPCLE-------AEEV 329
            :|:.|.....|  ||:|.|.|..|.     ::.:.|  :::|| :......||.       .|.:
  Fly    10 QDQDVSTCRLCHHNTDPNSLNIFDDTVQFCKDVSIAEVSKSLWSVQYDRNECLSELICSRCLEIL 74

  Fly   330 DLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIAIGDSQFSIKEENQL---VGSDDEAPMGVE 391
            :.|.:|: :..:.|.:..:.|.:..|....|:.....|:....:.||..:   |..::.|....|
  Fly    75 EEAFELR-KGMQEREQSLQEQLKEMIKDHPKHRPGLNGNPGVFVPEEGCIIVEVDPENLAESSEE 138

  Fly   392 DFMKLHVSGELPLSDEERFDGFADDDSDLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKA 456
            :|         .|..:..::.:.|||.:.::|.|::||||..:.:|.:..|      |....:.|
  Fly   139 EF---------ALGSDGEYENYDDDDEEEEEDYDEEDEEDGQNGEDVDMPL------GMDAAQMA 188

  Fly   457 KSGRRRRRRNKDEPNPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHV 521
            .........|..|..|       :|.|
  Fly   189 AQQSVANNANTTEARP-------KRAF-------------------------------------- 208

  Fly   522 QSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYL 586
                     .|..|:..|:.....:.|:::.|     :|.       |.:.|.:|:.:..::..|
  Fly   209 ---------LCQYCDLGFTLPAECQEHELAAH-----DPN-------APYCCNFCNIKLVTRPAL 252

  Fly   587 RKH--TLLHTDFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHN 649
            ..|  ||...|..|.|..|.:.|..|:.|::|...|||.|.|.|.:|..||:||..|..|||.|:
  Fly   253 ISHIKTLHDPDRPYVCAHCRKGFVRRSDLKKHTIVHTGVRPFTCNVCSKSFSRNTNLTKHMRIHS 317

  Fly   650 GEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHT--------- 705
            |.||:.|:.|.::|..|.::..|.|.|...|...|..|..||.|...|..|.:.||
  Fly   318 GVKPFVCQQCPRSFQTAVEMMRHTRSHGEVKAFQCGRCPYSFSRRDKLIAHQQVHTRRDMEQQQQ 382

  Fly   706 ---------------------------GERPYKCDQCPKSFTQSNDLKAHIRRHTGERYKCPHCD 743
                                       ..|.|.||.|.::|.:..||:.|...|....:.|..|:
  Fly   383 MGLIPPMEGDLQQQALQAKQKAAAQTKNSRYYHCDVCDRTFQRERDLQRHQALHMDSLFACKTCN 447

  Fly   744 AYFLQLYNMRNHCMSAH 760
            ..|.:...::.|.:.||
  Fly   448 QGFNRREQLQRHELEAH 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	73/324 (23%)
		C2H2 Zn finger	476..496	CDD:275368	2/19 (11%)
		zf-H2C2_2	488..513	CDD:290200	0/24 (0%)
		C2H2 Zn finger	504..525	CDD:275368	0/20 (0%)
		C2H2 Zn finger	532..548	CDD:275368	3/15 (20%)
		C2H2 Zn finger	573..593	CDD:275368	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	11/23 (48%)
		C2H2 Zn finger	628..648	CDD:275368	10/19 (53%)
		zf-H2C2_2	640..663	CDD:290200	10/22 (45%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	10/60 (17%)
		C2H2 Zn finger	712..732	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
prg	NP_001260253.1	zf-AD	16..94	CDD:285071	16/78 (21%)
		COG5048	<212..340	CDD:227381	43/139 (31%)
		C2H2 Zn finger	239..260	CDD:275368	5/20 (25%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
		zf-H2C2_2	280..305	CDD:290200	11/24 (46%)
		zf-C2H2	294..316	CDD:278523	11/21 (52%)
		C2H2 Zn finger	296..316	CDD:275368	10/19 (53%)
		zf-H2C2_2	308..331	CDD:290200	10/22 (45%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..372	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	7/19 (37%)
		C2H2 Zn finger	443..464	CDD:275368	4/20 (20%)
		C2H2 Zn finger	470..490	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.080