DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CG17612

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	648	Identity:	154/648 - (23%)
Similarity:	227/648 - (35%)	Gaps:	188/648 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 QTARLQCAHCQRTFSRRD-------------HLLRHIRNQ--------HRDV-----EEDLLRTW 253
            :|..|||.|.. ||..:.             ||...|..:        :.:|     |||.|...
  Fly    24 KTLCLQCLHMD-TFGTKHKGPRPETQINDKVHLEMSINGEDGLPEHPLYPEVQLVVKEEDALIKK 87

  Fly   254 PPADENTMNSD---GGDELVSAEVLLNEEDNED----------EVVGEAFQCNTNPISSNEDDGE 305
            ...:||.::::   |...:|..||..|...|.|          ||:.|....|.:.|...:...|
  Fly    88 KVIEENHIHNEEIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILEDHPANNDVIIIQDSVAE 152

  Fly   306 EANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIAIGDSQ 370
            |.        |.:..|..:|.|::                    |.|..| .|...|..|||..:
  Fly   153 EE--------LPVIKEEAIEGEDL--------------------QGEYFI-ITECLEEPAIGSCR 188

  Fly   371 FSIKEENQLVG-SDDEAPMGVEDFMKLHVSGELPLSDEERFDGFAD--------------DDSDL 420
            ..:::.:.|.. .||....|:.....|.....:|:   |:.|.|::              ||.:.
  Fly   189 VCLEQSDNLTNIFDDAHQYGIPIATILSQYTGMPV---EKGDSFSEYICVTCLDVVKNAFDDLES 250

  Fly   421 DDDDDD---DDEEDAGDDDDGEFRLKQEPLDGE---KP-----------LKKAKSGRRRRRRNK- 467
            .::...   ..:|:..|.|  ...:|.:|:|.|   ||           |..||.....|..|:
  Fly   251 KENTIQMYRQPKEEIIDID--SIPVKNKPVDYEVTGKPPHRCPQCPKIFLLAAKLQAHIRTHNET 313

  Fly   468 --DEPNPDNRCEVCQRTF-SRHC---HLLRHKL-----SHLEKKPHNCPHCPKAFARSDHLKAHV 521
              .|| |..:|.:|...: .|.|   |:..|:.     |.|| .|:.||||||.|..|..|:.|:
  Fly   314 RTTEP-PRLKCPMCPSIYMKRGCLEAHMWIHRASDERESELE-PPYRCPHCPKLFLYSSFLEIHI 376

  Fly   522 QS-------LHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKR 579
            |:       |.....|||:.|...||.:.:|:.|               :|:...|.|
  Fly   377 QTHEDVSQRLSRKSSHKCAQCADVFSDVSSLKDH---------------VKIHAGERT------- 419

  Fly   580 FSSKTYLRKHTLLHTDFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVH 644
                              :.|..|..:|:|.:.|:.|:..||   .|.|..|...|...:||..|
  Fly   420 ------------------FKCPLCLMSFQEESNLKSHDCAHT---RFKCHKCSKFFESQNYLDFH 463

  Fly   645 MRR-HNGEKPYKCRFCVKAFPRATDLKVH------ERYHTGTKPNL---CNTCGKSFHRAYNLTI 699
            .:: |..:.|:||..|.:.|.:...||.|      .::.....|..   |..|.|.|....|..:
  Fly   464 FKKSHTTKGPFKCIKCQQTFQKRNGLKEHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQM 528

  Fly   700 HMRTH----TGERPYKCDQCPKSFTQSNDLKAHIRRHTGERYKCPHCDAYFLQLYNMRNHCMS 758
            |..||    |....:.|.||.||:.....|..||..|.    :|.||...|...|.:..|..|
  Fly   529 HHATHKKVKTVIERHNCTQCKKSYQNKKLLTKHILSHN----RCVHCSMSFTSKYLLEQHTCS 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370	6/30 (20%)
		COG5048	<443..730	CDD:227381	88/333 (26%)
		C2H2 Zn finger	476..496	CDD:275368	6/28 (21%)
		zf-H2C2_2	488..513	CDD:290200	13/29 (45%)
		C2H2 Zn finger	504..525	CDD:275368	11/27 (41%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	0/19 (0%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	8/23 (35%)
		C2H2 Zn finger	628..648	CDD:275368	6/20 (30%)
		zf-H2C2_2	640..663	CDD:290200	8/23 (35%)
		C2H2 Zn finger	656..676	CDD:275368	6/25 (24%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		zf-C2H2	684..704	CDD:278523	6/19 (32%)
		zf-H2C2_2	696..721	CDD:290200	10/28 (36%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368	5/15 (33%)
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	9/61 (15%)
		C2H2 Zn finger	290..310	CDD:275368	4/19 (21%)
		C2H2 Zn finger	323..343	CDD:275370	5/19 (26%)
		zf-C2H2_8	356..438	CDD:292531	29/121 (24%)
		C2H2 Zn finger	359..379	CDD:275368	11/19 (58%)
		C2H2 Zn finger	394..414	CDD:275368	7/34 (21%)
		C2H2 Zn finger	422..438	CDD:275368	5/15 (33%)
		C2H2 Zn finger	447..463	CDD:275368	5/15 (33%)
		C2H2 Zn finger	476..505	CDD:275368	6/28 (21%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..584	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006715
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.050