DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and CG32767

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster

Alignment Length:	948	Identity:	178/948 - (18%)
Similarity:	287/948 - (30%)	Gaps:	308/948 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VCLKDVSLEGELHFIFNETPVEQDANLARILDECTLHQCERNDGMPPHMCSSCVEAARNAYRFKR 112
            :.:.|.:|..::.||..:.|:|||.:..:.......|..:.:.....|.........:...:.:.
  Fly    38 MAINDSALSQQIEFILQDAPMEQDDDPHQHTHVHHHHHSQHHPHSHSHQQQQQQHLQQQQQQQQH 102

  Fly   113 HAERSYCSLVALLGRSPQLKA-----------RGAEAASQTDQVALLPCEMCHDQFLNS------ 160
            |....:..|.......|...|           ..|.||:.|:..|............||
  Fly   103 HHPHHHLKLDNSSNNHPPTAAAAAAAVAVAATTAATAAAATNNSASFSSNSSSSNSNNSNHLDNQ 167

  Fly   161 ----LELRLHRNQVH-----RTTKEATSAGTDGLPSEDFKCKFCPQHFPHLRQLRSHLARSHEQT 216
                ::.:..:.|.|     |...:|| ..:..|.:.|.|.:...:..|.|..  .:|....|:.
  Fly   168 QQLLIQQQQQQQQHHLLNGRRIIIQAT-GNSSVLAASDIKEEDEEEEDPELND--ENLQDIEEEA 229

  Fly   217 ARLQCAHCQRTFSRRDHLLRHIRNQHRDVEEDLLRTWPPADENTMNSDGGDELVSAEVLLNEEDN 281
               |.|..........||...::   .::|||                  ||:...|...:|:|:
  Fly   230 ---QAAEADEEPETTAHLSTQVK---LELEED------------------DEMPDEEEEEDEDDD 270

  Fly   282 EDEVVGE-------AFQCNTNPISSNEDDGEEANGANQTL-----------WLHIKPEPCLEAEE 328
            |:...|:       |.|......||.......|.|.:|.|           ..|....|..||..
  Fly   271 EELQHGQLEYQISAATQTAGAATSSAAGGAATAGGGSQQLVQLPAGSIVSTTTHRLSVPVTEAAL 335

  Fly   329 VDL---------------------------------------------AMQLKLEKKRRRREKAE 348
            |.|                                             |.||.|:.::::...|
  Fly   336 VQLQRRPVYISNAVGGLTAGATYVRMPAAAVISRSPMTVLNVVQQALPATQLILQTQQQQTPAA- 399

  Fly   349 AQAETSIDRTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEERFDGF 413
                            |..:.|.::..|.|....:.:|                   .::|....
  Fly   400 ----------------AAAEQQLALALEQQRQQQEQQA-------------------QQQRQQQQ 429

  Fly   414 ADDDSDLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEK------PLKKAKSGRRRRRRNK--DEP 470
            ..:............::.....:  :.|.:|:.|..::      |:|.:.||......|.  :..
  Fly   430 QQEQQRQQQQQQQQQQQQQAQQE--QQRQQQQQLQQQQQQQQTHPVKHSASGSSSTNNNSTTNST 492

  Fly   471 NPDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLC 535
            |.:|.......|.:               ..:.|..|.:.|...:....| :|.|:| ..||::|
  Fly   493 NSNNNTPAATATVT---------------TSYQCVECVEKFDSKELFDIH-RSGHAN-NMKCAIC 540

  Fly   536 EAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHTDFLYAC 600
            ......|...|:|                        |..|..                   |.|
  Fly   541 NMVLKSLKNYEKH------------------------CLRCKP-------------------YEC 562

  Fly   601 KTCDETFRERAQLREHEKTHTGQRN----FLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVK 661
            :.|....|.|....:|.:.||||::    :.|.:|...|...:|.:||.:.||......|..|.|
  Fly   563 QICGRVVRFRPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHKKIHNENVNLTCEICGK 627

  Fly   662 AFPRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLK 726
            .|.....|:.|.:.|:|.|.:.|:.|||.|.:.|||.||.|||||:.|::|..|.|.....:.|:
  Fly   628 VFSALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHARTHTGDFPFECKICKKKLHTQSSLQ 692

  Fly   727 AHIRRHTGERYKCPHCDAYFLQLYNMRNHCMSAHNKHIETKTGRLQRTGLLDDGGQSHLTTVVMP 791
            .|::.|                                           |.|..|
  Fly   693 THMQVH-------------------------------------------LRDQPG---------- 704

  Fly   792 PARYPNELDPQLAATAAATAAGGAESTSSTTVIHSPGTYNATAAAPAN-TFDGANFTPTAVNTPA 855
                        ||.|||||||.|.|.:|    :|..:.|::.::.:| :.:|.:...:|..|..
  Fly   705 ------------AAAAAATAAGAASSKAS----NSSNSSNSSNSSSSNSSSNGVSAAVSAATTTT 753

  Fly   856 PFGAFNFPPAVMAHLMYNQGGS-------SQHSQSGSD 886
            ...... ||    |.:...|.|       |||.|...|
  Fly   754 TIVKLE-PP----HEIERPGTSSNQQLQQSQHHQMELD 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	11/72 (15%)
		C2H2 Zn finger	150..171	CDD:275368	3/30 (10%)
		C2H2 Zn finger	192..213	CDD:275370	3/20 (15%)
		C2H2 Zn finger	221..239	CDD:275370	3/17 (18%)
		COG5048	<443..730	CDD:227381	73/298 (24%)
		C2H2 Zn finger	476..496	CDD:275368	1/19 (5%)
		zf-H2C2_2	488..513	CDD:290200	3/24 (13%)
		C2H2 Zn finger	504..525	CDD:275368	5/20 (25%)
		C2H2 Zn finger	532..548	CDD:275368	4/15 (27%)
		C2H2 Zn finger	573..593	CDD:275368	2/19 (11%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..637	CDD:290200	8/27 (30%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	8/22 (36%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	11/19 (58%)
		zf-C2H2	684..704	CDD:278523	11/19 (58%)
		zf-H2C2_2	696..721	CDD:290200	13/24 (54%)
		C2H2 Zn finger	712..732	CDD:275368	5/19 (26%)
		C2H2 Zn finger	739..755	CDD:275368	0/15 (0%)
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	6/43 (14%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		C2H2 Zn finger	594..614	CDD:275368	6/19 (32%)
		C2H2 Zn finger	622..642	CDD:275368	6/19 (32%)
		zf-C2H2	648..670	CDD:278523	11/21 (52%)
		C2H2 Zn finger	650..670	CDD:275368	11/19 (58%)
		zf-H2C2_2	662..684	CDD:290200	12/21 (57%)
		C2H2 Zn finger	678..698	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930