DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and Zfp68

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_038945327.1	Gene:	Zfp68 / 304337	RGDID:	1310463	Length:	624	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	172/677 - (25%)
Similarity:	270/677 - (39%)	Gaps:	149/677 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 QVALLPCEMCHDQFLNSLELRLHRNQVHRTTKEATSAGTDGLPS-EDFKCKFCPQHFPHLRQLRS 207
            ||.::.|::.         |||                :.||.| ||...:|..|.:..|.:.:.
  Rat    25 QVPIIECQIL---------LRL----------------SMGLVSFEDIAVEFTWQEWQDLNEGQR 64

  Fly   208 HLARS---HEQTARLQCAHCQRTFSRRDHLLRHIRNQHRDVEEDLLRTW---------PPADE-N 259
            .|.|.   ...:..|...||:    .:..|:.::        |..|.:|         |...: |
  Rat    65 TLYRDVMLENYSNLLFLGHCK----TKPELIFNL--------EQRLGSWIVEASHQSIPDFQKVN 117

  Fly   260 TMNSDGGDELVS--AEVLLNEEDNEDEVVGEAFQC--NTNPISSNEDDGEEANGANQ---TLW-- 315
            |:|....:....  .:|.|| .|..:|:.|....|  :||..|:.....|::.|.:.   |||
  Rat   118 TLNETSPETKARHVCQVPLN-SDTSEELAGIGNTCTVSTNCFSNQTVKSEDSLGMSPRKFTLWKD 181

  Fly   316 --LHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKN----EHIAIGDSQFSIK 374
              ||...:.....||.|                       .::.|||:    |.:::...|.|..
  Rat   182 VYLHNDVDEVEVGEEPD-----------------------DLNGTVKSVRHPERVSLYRFQSSQG 223

  Fly   375 EENQLVGSDDEAPMGVEDFMKLHVSGELPLS-----------DEERFDGFADDDSDLDDDDDDDD 428
            ....|:....   ...:..:..|...|...|           .:.|...|..:.|::..:..|.:
  Rat   224 YFQSLIPGKS---FNTKAVLLTHKFNEYAKSLVDTAFIGKEMAQIRVKSFECNVSEIKCNKSDLN 285

  Fly   429 EEDAGDDDDGEFRLK--QEPLDGEKPLKKAK--------------------SGRRRRRRNKDEPN 471
            |.|...:.:..::..  :.|...|..|.|.|                    |..::.||.|
  Rat   286 ENDPVHEGEKHYKCSDFENPFIIESYLPKHKGQHEKLFVQKGYEFSQQSEVSLHQKIRRGK---- 346

  Fly   472 PDNRCEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHS-NKEHKCSLC 535
            ....|::|.:.|.......||:.:|..:||:.|..|.|||.:..||..| |.:|: .:.:.|..|
  Rat   347 KTYECKICGKCFYWKTSFNRHQSTHTGEKPYECTECSKAFCQKSHLTQH-QRVHTGERPYICFEC 410

  Fly   536 EAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYA 599
            ..||.|...|..|: ..|.||  :|          :.|:.|.|.|..|..|..|..:|| :..|.
  Rat   411 RKAFYRKSELTDHQ-RIHTGE--KP----------YECKECGKAFCQKPQLTLHQRIHTGEKPYE 462

  Fly   600 CKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFP 664
            |..|.:.|..::.|..|::||||::.:.|.:|..||........|.|.|.|||||:|:.|:|.|.
  Rat   463 CAECGKAFSTKSYLTVHQRTHTGEKPYECTVCRKSFICKSSFSHHWRTHTGEKPYECKQCMKTFY 527

  Fly   665 RATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHI 729
            |.:.|..|:|.|||.|...|..|.|:|:...:|.:|.||||||:||:|.:|.|:|...::||.|.
  Rat   528 RKSGLTRHQRTHTGDKRYECQLCQKAFYCTSHLIVHQRTHTGEKPYECKECRKAFYDKSNLKRHQ 592

  Fly   730 RRHTGER-YKCPHCDAYFLQLYNMRNH 755
            :.||.:: .:|...:.:||.  |...|
  Rat   593 KIHTAKKASECKQSNKFFLS--NTSQH 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368	4/20 (20%)
		C2H2 Zn finger	192..213	CDD:275370	5/23 (22%)
		C2H2 Zn finger	221..239	CDD:275370	3/17 (18%)
		COG5048	<443..730	CDD:227381	102/310 (33%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		zf-H2C2_2	488..513	CDD:290200	10/24 (42%)
		C2H2 Zn finger	504..525	CDD:275368	9/20 (45%)
		C2H2 Zn finger	532..548	CDD:275368	6/15 (40%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..637	CDD:290200	10/23 (43%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	11/22 (50%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		C2H2 Zn finger	684..704	CDD:275368	7/19 (37%)
		zf-C2H2	684..704	CDD:278523	7/19 (37%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..755	CDD:275368	4/15 (27%)
Zfp68	XP_038945327.1	KRAB	42..102	CDD:214630	14/71 (20%)
		COG5048	<325..507	CDD:227381	56/199 (28%)
		C2H2 Zn finger	327..343	CDD:275368	1/15 (7%)
		C2H2 Zn finger	351..371	CDD:275368	5/19 (26%)
		C2H2 Zn finger	379..399	CDD:275368	9/20 (45%)
		C2H2 Zn finger	407..427	CDD:275368	7/20 (35%)
		C2H2 Zn finger	435..455	CDD:275368	7/19 (37%)
		C2H2 Zn finger	463..483	CDD:275368	5/19 (26%)
		C2H2 Zn finger	491..511	CDD:275368	6/19 (32%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		zf-H2C2_2	532..554	CDD:404364	10/21 (48%)
		COG5048	545..>618	CDD:227381	28/75 (37%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000