DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and Zbtb4

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001291281.1	Gene:	Zbtb4 / 287441	RGDID:	1307184	Length:	984	Species:	Rattus norvegicus

Alignment Length:	443	Identity:	99/443 - (22%)
Similarity:	143/443 - (32%)	Gaps:	138/443 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   499 KKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPG-- 561
            ::|..||.|.|:|.....|:.|        |.:|              |...:.....||.||
  Rat   207 RRPFPCPRCGKSFIHPKRLQTH--------EAQC--------------RRGSNTRGSAGLGPGGS 249

  Fly   562 ----------SELKLQLA-----EHTCEYCSKRFSSKTYLRKHTLLHTDFLYACKTCDETFRERA 611
                      |.|...::     ||..:                ::....||.|..|:.::...:
  Rat   250 GPGGPAGVDASALPQPVSFRDGPEHVVK----------------VVGGHVLYVCAACERSYVTLS 298

  Fly   612 QLREHEKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYH 676
            .|:.|...|:.:|.:.|..|...||..:|...|...|.||:.|:|.||.:.|....:||.|:|..
  Rat   299 SLKRHSNVHSWRRKYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWETFVTYYNLKTHQRAF 363

  Fly   677 TGTKPNL--------------CNTCGKSFHRAYNLTIHMRTHTGERPYK-----CDQCPKSFTQS 722
            .|..|.|              .||.     :.|.| :.||  ..:||||     ..:.|.|.:..
  Rat   364 HGISPGLLASEKTPNGGYKPKLNTL-----KLYRL-LPMR--AAKRPYKTYSQGAPEAPLSPSLH 420

  Fly   723 NDLKAHIRR----------HTGERYKCPHCDAYFLQLYNMRNHCMSAHNKHIETKTGRLQRTGLL 777
            ..:.|.:..          ..|.    ||....|.       |...:...|..:.:|......:.
  Rat   421 TPVPAVMPASPQPLLPSVPEPGP----PHSVITFA-------HPAPSVIVHGSSSSGAAGGGPVG 474

  Fly   778 DDGGQSHLTTVVMPPARYPNELD-----PQLAATAAATAAGGAESTSSTTVIHSPGTYNATAAAP 837
            ..|.|:........|.|.|.:.:     |:.|||..        |.:||.||      .||||.|
  Rat   475 TGGSQAASVITYTTPPRPPKKREYPPPPPEPAATPT--------SPASTAVI------PATAAGP 525

  Fly   838 ANTFD---GANFTP--TAVNTPAPFGAFNFPPAVMAHLMYNQGGSSQHSQSGS 885
            |...:   |.|...  |...|..|.|..:           ..|||...:..||
  Rat   526 ATATEEAKGRNLRAGRTLTYTAKPVGGVS-----------GSGGSPTGTGRGS 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	61/266 (23%)
		C2H2 Zn finger	476..496	CDD:275368
		zf-H2C2_2	488..513	CDD:290200	6/13 (46%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	1/15 (7%)
		C2H2 Zn finger	573..593	CDD:275368	0/19 (0%)
		C2H2 Zn finger	600..620	CDD:275368	4/19 (21%)
		zf-H2C2_2	613..637	CDD:290200	7/23 (30%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..663	CDD:290200	9/22 (41%)
		C2H2 Zn finger	656..676	CDD:275368	8/19 (42%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
		zf-C2H2	684..704	CDD:278523	6/19 (32%)
		zf-H2C2_2	696..721	CDD:290200	9/29 (31%)
		C2H2 Zn finger	712..732	CDD:275368	3/29 (10%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
Zbtb4	NP_001291281.1	BTB_POZ_ZBTB4	12..160	CDD:349504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..104
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q9P1Z0	165..324		30/154 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..210		0/2 (0%)
		zf-C2HC_2	211..233	CDD:404749	9/43 (21%)
		C2H2 Zn finger	212..228	CDD:275370	6/15 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..262		9/56 (16%)
		C2H2 Zn finger	287..307	CDD:275368	4/19 (21%)
		C2H2 Zn finger	315..335	CDD:275368	6/19 (32%)
		zf-C2H2_4	341..364	CDD:404733	9/22 (41%)
		C2H2 Zn finger	343..361	CDD:275368	7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..575		32/132 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..696
		C2H2 Zn finger	701..719	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..734
		zf-C2H2	736..758	CDD:395048
		C2H2 Zn finger	738..758	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..836
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	853..876
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..984
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100