DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and Zfp263

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_006245892.1	Gene:	Zfp263 / 287076	RGDID:	1307301	Length:	680	Species:	Rattus norvegicus

Alignment Length:	788	Identity:	185/788 - (23%)
Similarity:	289/788 - (36%)	Gaps:	251/788 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 LARILDECTLHQCERNDGMPPHMCSSCVEAARNAYRFKRHAERSYCSLVALLGRSPQLKARGAEA 138
            :.::.::||..|     .:||.......||:...:|..|..:.|          .|:      ||
  Rat    17 IVKLEEDCTWSQ-----EVPPPEPEPSPEASHLRFRRFRFQDAS----------GPR------EA 60

  Fly   139 ASQTDQVA---LLPCEMCHDQFLNSLELRLHRNQVHRTTKEATSAGTDGLPSEDFKCKFCPQHF- 199
            .:|..::.   |.|.....:|.|..|.|                        |.| ....||..
  Rat    61 LNQLQELCRGWLRPEMRTKEQILELLVL------------------------EQF-LTILPQEIQ 100

  Fly   200 PHLRQLRSHLARSHEQTARLQCAHCQRTFSRRDHLLRHIRNQHRDVEEDLLRTWPPADENTMNSD 264
            ..:::||   ..|.|:...|    .:|.......|.:.:.||.|
  Rat   101 SRVQELR---PESGEEAVTL----VERMQKELGKLRQQVTNQGR--------------------- 137

  Fly   265 GGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSNEDDG-------------------EEANGA 310
                  .||||| ||....|..||:......|:.:....|                   |.|..|
  Rat   138 ------GAEVLL-EEPLPLETAGESPSFKLEPMETERSPGPRLQELLDPSPKRDSQAVKERALSA 195

  Fly   311 NQTLWLHI-KPEPCLEAEEV----------DLAMQLKLE-------KKRRRREKAEAQAET--SI 355
            .   ||.: .||..:|.:::          |:||.:..|       |:...|:..:...|.  ::
  Rat   196 P---WLSLFPPEGNVEDKDMTGTQLPESLEDMAMYISQEWDHQDHSKRAPSRDMVQDSYENVGTL 257

  Fly   356 DRTVKNEHIAI-----GDSQFSIKEENQLVGSDDEAP-MGVEDFMKLHVS--------------- 399
            :..:.::.::.     |...:....:....|.:...| :|||.|.....|
  Rat   258 ESCIPSQEVSSTQVEQGGKPWDPSVQTCKEGMNPRNPVLGVEKFENQERSVESVSPESTHPPVLL 322

  Fly   400 -----GELPLSDEERFDGFADDDSDLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSG 459
                 .|:|.|.|:                        |..||.|...:..|   |..::::..|
  Rat   323 PGQARREVPWSPEQ------------------------GRLDDREGHWECPP---EDKIEESLMG 360

  Fly   460 RRRRR---RNKDEPNPDNRCEVCQRTFSRHCHLLRH-------KL-------------------- 494
            ....|   :.|::|...:.|.:|.:.||.:.:|:||       ||
  Rat   361 TPSCRGLVQAKEQPKKLHLCALCGKNFSNNSNLIRHQRIHAAEKLCMDVECGEVFGGHPHFLSLH 425

  Fly   495 -SHLEKKPHNCPHCPKAFARSDHLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGL 558
             :|:.::.|.|..|.|.|:::.||..|.::....|..:|::|..:||....|.||: ..|.||
  Rat   426 RTHVGEEAHKCLECGKCFSQNTHLTRHQRTHTGEKPFQCNVCGKSFSCNSNLNRHQ-RTHTGE-- 487

  Fly   559 EPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREHEKTHTG 622
            :|          :.|..|.:.|:..:.|.:|..:|| :..|.|..|.::|...:.|..||:||..
  Rat   488 KP----------YKCPECGEIFAHSSNLLRHQRIHTGERPYRCSECGKSFSRSSHLVIHERTHEK 542

  Fly   623 QR--------------------------NFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVK 661
            :|                          .|.|..||.||.:..:|..|.|.|.|||||||..|.:
  Rat   543 ERLDPLPECGQGINDSAPFLTNHRVEKKLFECSTCGKSFRQGMHLTRHQRTHTGEKPYKCILCGE 607

  Fly   662 AFPRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLK 726
            .|...::|..|:|.|||.||..|:.||.||..:.|...|:|||||||||||.:|.:||::|:.|.
  Rat   608 NFSHRSNLIRHQRIHTGEKPYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLT 672

  Fly   727 AHIRRHTG 734
            :|.|.|||
  Rat   673 SHQRTHTG 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	10/46 (22%)
		C2H2 Zn finger	150..171	CDD:275368	4/20 (20%)
		C2H2 Zn finger	192..213	CDD:275370	4/21 (19%)
		C2H2 Zn finger	221..239	CDD:275370	2/17 (12%)
		COG5048	<443..730	CDD:227381	104/344 (30%)
		C2H2 Zn finger	476..496	CDD:275368	9/47 (19%)
		zf-H2C2_2	488..513	CDD:290200	11/52 (21%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	12/49 (24%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	12/22 (55%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
		zf-C2H2	684..704	CDD:278523	8/19 (42%)
		zf-H2C2_2	696..721	CDD:290200	16/24 (67%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368
Zfp263	XP_006245892.1	SCAN	41..151	CDD:128708	35/185 (19%)
		SCAN	41..127	CDD:280241	24/133 (18%)
		KRAB	220..278	CDD:214630	8/57 (14%)
		KRAB	220..257	CDD:279668	7/36 (19%)
		COG5048	<367..531	CDD:227381	43/176 (24%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-C2H2	380..400	CDD:278523	7/19 (37%)
		zf-C2H2	434..456	CDD:278523	8/21 (38%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		zf-H2C2_2	448..473	CDD:290200	7/24 (29%)
		COG5048	<460..646	CDD:227381	62/198 (31%)
		C2H2 Zn finger	464..484	CDD:275368	7/20 (35%)
		zf-H2C2_2	476..501	CDD:290200	10/37 (27%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		zf-H2C2_2	504..529	CDD:290200	8/24 (33%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		zf-C2H2	572..594	CDD:278523	9/21 (43%)
		C2H2 Zn finger	574..594	CDD:275368	8/19 (42%)
		zf-H2C2_2	586..611	CDD:290200	13/24 (54%)
		C2H2 Zn finger	602..622	CDD:275368	6/19 (32%)
		zf-H2C2_2	614..639	CDD:290200	13/24 (54%)
		COG5048	626..>679	CDD:227381	27/52 (52%)
		C2H2 Zn finger	630..650	CDD:275368	8/19 (42%)
		zf-H2C2_2	645..667	CDD:290200	15/21 (71%)
		C2H2 Zn finger	658..678	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000