DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2202 and ZNF778

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001188336.1	Gene:	ZNF778 / 197320	HGNCID:	26479	Length:	757	Species:	Homo sapiens

Alignment Length:	685	Identity:	182/685 - (26%)
Similarity:	270/685 - (39%)	Gaps:	164/685 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 PHLRQLRSHLARSHE-QTARLQCAH-----CQRT-----FSRRDHLLRHIRNQHRDVEEDLLRTW 253
            |.|||.||....|:| ||||   :|     |.||     ||....|..|:|.|:
Human   118 PALRQDRSWFRASNETQTAR---SHNGGQLCDRTQCGEAFSEHSGLSTHVRTQN----------- 168

  Fly   254 PPADENTMNSDGGDELVSAEVLLNEEDNEDEVVGE---AFQCNTNPIS----------------- 298
             ..|....|....|..:..:..|.:...:..|:|:   ||....|.:|
Human   169 -TGDSCVSNHYERDFFIPCQKTLFKIGEQFSVLGQCGKAFSSTPNVVSQQACTRDRSLDYSSCGE 232

  Fly   299 -----------SNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRR-----REKA 347
                       :...:|||.       |   |.:||.:|....:.....:|....|     ||..
Human   233 VFLNQSYLQARAGSHNGEET-------W---KWKPCGKALTHSMGCATPVEMHAVRNPHVCRECG 287

  Fly   348 EAQAETSIDRTVKNEHIAIGDSQFSIKEENQLVGSDDEAPMGVEDFMKLHVSGELPLSDEE---R 409
            :|...|:.  ......:..|:....::|    .|........:...:::| :.|.|...:|   .
Human   288 KAFRYTAY--LTGRVQVHPGEKPCELEE----CGKASPVSSSLTQHVRIH-AAEKPCECKECGKA 345

  Fly   410 FDGFADDDSDLDDDDDDDDEE--DAGDDDDGEFRLKQ--EPLDGEKPLKKAKSGRRRRRRNKDEP 470
            |.|.:.....:..|......|  |.|....|.:.|.:  :....|||......|  :..||....
Human   346 FTGLSGLSKHVQTDPGQKPYECKDCGKACGGFYLLNEHGKTHTREKPFACVVCG--KYFRNSSCL 408

  Fly   471 NPDNR---------CEVCQRTFSRHCHLLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHS 526
            |...|         |..|.:.|:..|.|.||..:|..:||:.|..|.|||..|..|..||::...
Human   409 NNHVRIHTGIKPYTCSYCGKAFTVRCGLTRHVRTHTGEKPYTCKDCGKAFCTSSGLTEHVRTHTG 473

  Fly   527 NKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTL 591
            .|.::|..|..:|:...:|..| ...|.||  :|          :.|:.|.|.|:.::.|.||..
Human   474 EKPYECKDCGKSFTVSSSLTEH-ARIHTGE--KP----------YECKQCGKAFTGRSGLTKHMR 525

  Fly   592 LHT-DFLYACKTCDETFRERAQLREHEKTHTGQRNFLCCICGDSFAR----NDYLRV-------- 643
            .|| :..|.||.|.:.:.....|.||.||||.::.|:|.:|..||..    |.::::
Human   526 THTGEKPYECKDCGKAYNRVYLLNEHVKTHTEEKPFICTVCRKSFRNSSCLNKHIQIHTGIKPYE 590

  Fly   644 ----------------HMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKPNLCNTCGKSFH 692
                            |:|.|.|||||:|:.|.|||..::.|.||.|.|||.||.:|..|||:|.
Human   591 CKDCGKTFTVSSSLTEHIRTHTGEKPYECKVCGKAFTTSSHLIVHIRTHTGEKPYICKECGKAFA 655

  Fly   693 RAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER-YKCPHCDAYFLQLYNMRNH- 755
            .:.:|..|.||||||:||.|::|.|:|..|:.|..|.|.|||:: |||..|...:.:.|.::.|
Human   656 SSSHLIEHRRTHTGEKPYICNECGKAFRASSHLHKHGRIHTGQKPYKCKECGKAYNRFYLLKEHL 720

  Fly   756 ----------------------CMSAHNK-HIETK 767
                                  |::.|.: |.:.|
Human   721 KTYTEEQVFVCKDCGKSFKNSSCLNHHTQIHTDEK 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370	6/12 (50%)
		C2H2 Zn finger	221..239	CDD:275370	8/27 (30%)
		COG5048	<443..730	CDD:227381	107/326 (33%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	11/24 (46%)
		C2H2 Zn finger	504..525	CDD:275368	9/20 (45%)
		C2H2 Zn finger	532..548	CDD:275368	4/15 (27%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	613..637	CDD:290200	12/23 (52%)
		C2H2 Zn finger	628..648	CDD:275368	7/47 (15%)
		zf-H2C2_2	640..663	CDD:290200	11/46 (24%)
		C2H2 Zn finger	656..676	CDD:275368	9/19 (47%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
		zf-C2H2	684..704	CDD:278523	8/19 (42%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
ZNF778	NP_001188336.1	KRAB	42..100	CDD:214630
		C2H2 Zn finger	283..303	CDD:275368	4/21 (19%)
		C2H2 Zn finger	311..331	CDD:275368	2/23 (9%)
		C2H2 Zn finger	339..358	CDD:275368	3/18 (17%)
		C2H2 Zn finger	367..387	CDD:275368	4/19 (21%)
		COG5048	380..747	CDD:227381	119/381 (31%)
		C2H2 Zn finger	395..415	CDD:275368	5/21 (24%)
		C2H2 Zn finger	423..443	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	9/19 (47%)
		C2H2 Zn finger	479..499	CDD:275368	5/20 (25%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		C2H2 Zn finger	535..555	CDD:275368	7/19 (37%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		C2H2 Zn finger	591..611	CDD:275368	2/19 (11%)
		C2H2 Zn finger	619..639	CDD:275368	9/19 (47%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		C2H2 Zn finger	675..695	CDD:275368	8/19 (42%)
		C2H2 Zn finger	703..722	CDD:275368	4/18 (22%)
		C2H2 Zn finger	731..751	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000