DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and ZNF816

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_001026835.1	Gene:	ZNF816 / 125893	HGNCID:	26995	Length:	651	Species:	Homo sapiens

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	226/537 - (42%)	Gaps:	103/537 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 NGANQTLWLHIKPEPCLEAEEVDLAMQLKLEKKRRRREKAEAQAETSIDRTVKNEHIAIGDSQF- 371
            |.|.:.|:..:..|.....|.||.:::..:|....|.........|...:..|:.|  |||..|
Human    42 NPAQRALYRAVMLENYRNLEFVDSSLKSMMEFSSTRHSITGEVIHTGTLQRHKSHH--IGDFCFP 104

  Fly   372 SIKEE--------NQLVGSDDEAPM-------GVEDFMKLHVSGELPLSDE---------ERFDG 412
            .:|::        .::..:..||||       |..|......:|..|:.|:         .....
Human   105 EMKKDIHHFEFQWQEVERNGHEAPMTKIKKLTGSTDRSDHRHAGNKPIKDQLGLSFHSHLPELHM 169

  Fly   413 FADDDSDLDDDDDDDDEEDAGDDDDGEFRLK-------------------QEPLDGEKPLKKAKS 458
            |.......:..|.......|.:......|||                   ||....|||.:..:.
Human   170 FQTKGKISNQLDKSIGASSASESQRISCRLKTHISNKYGKNFLHSSFTQIQEICMREKPCQSNEC 234

  Fly   459 GRR-------RRRRNKDEPNPDNRCEVCQRTFSR--------HCH-------------------- 488
            |:.       ||.........:.:|:||.:.|::        .||
Human   235 GKAFNYSSLLRRHHITHSREREYKCDVCGKIFNQKQYIVYHHRCHTGEKTYKCNECGKTFTQMSS 299

  Fly   489 LLRHKLSHLEKKPHNCPHCPKAFARSDHLKAHVQSLHS-NKEHKCSLCEAAFSRLDALERHKVSK 552
            |:.|:..|..:||:.|..|.|.|:....|:.| :.||: .|.:||:.|...|.|..||..|| :.
Human   300 LVCHRRLHTGEKPYKCNECGKTFSEKSSLRCH-RRLHTGEKPYKCNECGKTFGRNSALVIHK-AI 362

  Fly   553 HNGEGLEPGSELKLQLAEHTCEYCSKRFSSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREH 616
            |.||  :|          :.|..|.|.||.|:.|:.|.:||| :..|.|:.||..:..|:.|..|
Human   363 HTGE--KP----------YKCNECGKTFSQKSSLQCHHILHTGEKPYKCEECDNVYIRRSHLERH 415

  Fly   617 EKTHTGQRNFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTKP 681
            .|.|||:.::.|.:|...|..:.||..|.|.|.|||||||..|.::|.|.:.|:.|...|||.||
Human   416 RKIHTGEGSYKCKVCDKVFRSDSYLAEHQRVHTGEKPYKCNKCGRSFSRKSSLQYHHTLHTGEKP 480

  Fly   682 NLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTGER-YKCPHCDAY 745
            ..||.|||.|.|..||..|.|.|.||:||||::|.|.|::.:.|:.|.|.||||: |||..||..
Human   481 YTCNECGKVFSRRENLARHHRLHAGEKPYKCEECDKVFSRRSHLERHRRIHTGEKPYKCKVCDKA 545

  Fly   746 FLQLYNMRNHCMSAHNK 762
            |     ..:.|::.|.:
Human   546 F-----RSDSCLANHTR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	112/342 (33%)
		C2H2 Zn finger	476..496	CDD:275368	8/47 (17%)
		zf-H2C2_2	488..513	CDD:290200	10/44 (23%)
		C2H2 Zn finger	504..525	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..548	CDD:275368	6/15 (40%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		zf-H2C2_2	613..637	CDD:290200	9/23 (39%)
		C2H2 Zn finger	628..648	CDD:275368	7/19 (37%)
		zf-H2C2_2	640..663	CDD:290200	13/22 (59%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	11/19 (58%)
		zf-C2H2	684..704	CDD:278523	11/19 (58%)
		zf-H2C2_2	696..721	CDD:290200	14/24 (58%)
		C2H2 Zn finger	712..732	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..755	CDD:275368	4/15 (27%)
ZNF816	NP_001026835.1	KRAB	24..64	CDD:307490	5/21 (24%)
		C2H2 Zn finger	232..251	CDD:275368	3/18 (17%)
		C2H2 Zn finger	259..279	CDD:275368	4/19 (21%)
		COG5048	283..650	CDD:227381	110/294 (37%)
		C2H2 Zn finger	287..307	CDD:275368	2/19 (11%)
		C2H2 Zn finger	315..335	CDD:275368	6/20 (30%)
		C2H2 Zn finger	343..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..391	CDD:275368	8/19 (42%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	6/19 (32%)
		C2H2 Zn finger	483..503	CDD:275368	11/19 (58%)
		C2H2 Zn finger	511..531	CDD:275368	7/19 (37%)
		C2H2 Zn finger	539..559	CDD:275368	6/24 (25%)
		C2H2 Zn finger	567..587	CDD:275368
		C2H2 Zn finger	595..615	CDD:275368
		C2H2 Zn finger	623..643	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000