DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2202 and ZNF263

DIOPT Version :9

Sequence 1:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_005732.2	Gene:	ZNF263 / 10127	HGNCID:	13056	Length:	683	Species:	Homo sapiens

Alignment Length:	769	Identity:	194/769 - (25%)
Similarity:	296/769 - (38%)	Gaps:	197/769 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 EQDANLARILDECTLHQCERNDGMPPHMCSSCVEAARNAYRFKRHAERSYCSLVALLGRSPQLKA 133
            |::..|...|:|    .|..:..:||.......||:.  .||:|.
Human     9 EREGLLIVKLEE----DCAWSQELPPPDPGPSPEASH--LRFRRF-------------------- 47

  Fly   134 RGAEAASQTDQVALLPCEMCHDQFLNSLELRLHRNQVHRTTKEATSAGTDGLPSEDFKCKFCPQH 198
            |..|||...:.::.|. |:||. :|.. |:|         |||..   .:.|..|.| ....||
Human    48 RFQEAAGPREALSRLQ-ELCHG-WLRP-EMR---------TKEQI---LELLVLEQF-LTILPQ- 95

  Fly   199 FPHLRQLRSHLARSHEQT---ARLQCAHCQRTFSR-RDHLLRHIRNQHRDVEEDLLRTWPPADEN 259
                 :::|.:...|.::   |.......||...| |..:..|.|.....:||       |....
Human    96 -----EIQSRVQELHPESGEEAVTLVEDMQRELGRLRQQVTNHGRGTEVLLEE-------PLPLE 148

  Fly   260 TMNSDGGDELVSAEVLLNEEDNEDEVVGEAFQCNTNPISSNEDDGEEANGANQTLWLHI-KPEPC 323
            |.......:|...|...:......|::|.:.|.:...:.      |.|..|.   ||.: .||..
Human   149 TARESPSFKLEPMETERSPGPRLQELLGPSPQRDPQAVK------ERALSAP---WLSLFPPEGN 204

  Fly   324 LEAEEV----------DLAMQLKLEKKRRRREKAEAQAETSIDRTVKN-----EHI--------A 365
            :|.:|:          |:||.:..|:...:.....|.:..::..:.:|     .||        .
Human   205 MEDKEMTGPQLPESLEDVAMYISQEEWGHQDPSKRALSRDTVQESYENVDSLESHIPSQEVPGTQ 269

  Fly   366 IGD-------SQFSIKEENQLVGSDDEAPM-GVEDFMKL---------HVSGELPLSDEERFDGF 413
            :|.       |..|.||     |.....|. |.|.|..|         ::..::.|.|:.|  |.
Human   270 VGQGGKLWDPSVQSCKE-----GLSPRGPAPGEEKFENLEGVPSVCSENIHPQVLLPDQAR--GE 327

  Fly   414 ADDDSDLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRRRRNKDEPNPDNRCEV 478
            .....:|....|....:.|...:.|.          |:.|..|.|||...|..:.:|...:.|.:
Human   328 VPWSPELGRPHDRSQGDWAPPPEGGM----------EQALAGASSGRELGRPKELQPKKLHLCPL 382

  Fly   479 CQRTFSRHCHLLRHK----------------------------LSHLEKKPHNCPHCPKAFARSD 515
            |.:.||.:.:|:||:                            .:||.::.|.|..|.|.|:::.
Human   383 CGKNFSNNSNLIRHQRIHAAERLCMGVDCTEIFGGNPRFLSLHRAHLGEEAHKCLECGKCFSQNT 447

  Fly   516 HLKAHVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRF 580
            ||..|.::....|.::|::|...||....|.||: ..|.||  :|          :.|..|.:.|
Human   448 HLTRHQRTHTGEKPYQCNICGKCFSCNSNLHRHQ-RTHTGE--KP----------YKCPECGEIF 499

  Fly   581 SSKTYLRKHTLLHT-DFLYACKTCDETFRERAQLREHEKTHTGQR-------------------- 624
            :..:.|.:|..:|| :..|.|..|.::|...:.|..||:||..:|
Human   500 AHSSNLLRHQRIHTGERPYKCPECGKSFSRSSHLVIHERTHERERLYPFSECGEAVSDSTPFLTN 564

  Fly   625 ---------NFLCCICGDSFARNDYLRVHMRRHNGEKPYKCRFCVKAFPRATDLKVHERYHTGTK 680
                     .|.|..||.||.:..:|..|.|.|.|||||||..|.:.|...::|..|:|.|||.|
Human   565 HGAHKAEKKLFECLTCGKSFRQGMHLTRHQRTHTGEKPYKCTLCGENFSHRSNLIRHQRIHTGEK 629

  Fly   681 PNLCNTCGKSFHRAYNLTIHMRTHTGERPYKCDQCPKSFTQSNDLKAHIRRHTG 734
            |..|:.||.||..:.|...|:|||||||||||.:|.:||::|:.|.:|.|.|||
Human   630 PYTCHECGDSFSHSSNRIRHLRTHTGERPYKCSECGESFSRSSRLMSHQRTHTG 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071	12/51 (24%)
		C2H2 Zn finger	150..171	CDD:275368	6/20 (30%)
		C2H2 Zn finger	192..213	CDD:275370	3/20 (15%)
		C2H2 Zn finger	221..239	CDD:275370	5/18 (28%)
		COG5048	<443..730	CDD:227381	105/344 (31%)
		C2H2 Zn finger	476..496	CDD:275368	7/47 (15%)
		zf-H2C2_2	488..513	CDD:290200	10/52 (19%)
		C2H2 Zn finger	504..525	CDD:275368	7/20 (35%)
		C2H2 Zn finger	532..548	CDD:275368	5/15 (33%)
		C2H2 Zn finger	573..593	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	6/19 (32%)
		zf-H2C2_2	613..637	CDD:290200	12/52 (23%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..663	CDD:290200	12/22 (55%)
		C2H2 Zn finger	656..676	CDD:275368	6/19 (32%)
		C2H2 Zn finger	684..704	CDD:275368	8/19 (42%)
		zf-C2H2	684..704	CDD:278523	8/19 (42%)
		zf-H2C2_2	696..721	CDD:290200	16/24 (67%)
		C2H2 Zn finger	712..732	CDD:275368	8/19 (42%)
		C2H2 Zn finger	739..755	CDD:275368
ZNF263	NP_005732.2	SCAN	38..149	CDD:128708	36/161 (22%)
		Dendrin	<128..>347	CDD:317849	45/241 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..185		6/37 (16%)
		KRAB	218..277	CDD:214630	9/58 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..301		13/75 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..368		13/57 (23%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-C2H2	380..400	CDD:306579	7/19 (37%)
		COG5048	<434..649	CDD:227381	70/227 (31%)
		C2H2 Zn finger	436..456	CDD:275368	7/19 (37%)
		C2H2 Zn finger	464..484	CDD:275368	7/20 (35%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		COG5048	629..>682	CDD:227381	27/52 (52%)
		C2H2 Zn finger	633..653	CDD:275368	8/19 (42%)
		C2H2 Zn finger	661..681	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910