DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and FUBP3

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_003925.1	Gene:	FUBP3 / 8939	HGNCID:	4005	Length:	572	Species:	Homo sapiens

Alignment Length:	622	Identity:	134/622 - (21%)
Similarity:	216/622 - (34%)	Gaps:	191/622 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 QAQRAAVGLNGVEFEGSKLHAEQL-DKNQRRSQRNQRNPY--PGMPGPGRQADFPL--------- 145
            |.|.|.||:....|..:.....|: .|.......|...|.  |.:.|.|.|.. ||
Human     6 QGQSAPVGMKAEGFVDALHRVRQIAAKIDSIPHLNNSTPLVDPSVYGYGVQKR-PLDDGVGNQLG 69

  Fly   146 -----RILVQSE------MVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPEN 199
                 |.::..|      |||.||||.|..|..|..:|..::.: ..|:.|..|:...:.|.||:
Human    70 ALVHQRTVITEEFKVPDKMVGFIIGRGGEQISRIQAESGCKIQI-ASESSGIPERPCVLTGTPES 133

  Fly   200 CTNACKRILEVMQQEAISTNKGELSPEC------------SEICLKILAHNNLIGRIIGKSGNTI 252
            ...| ||:|            |::...|            :....:||...:.:|.:||:.|.||
Human   134 IEQA-KRLL------------GQIVDRCRNGPGFHNDIDSNSTIQEILIPASKVGLVIGRGGETI 185

  Fly   253 KRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLM 317
            |::.:.|..|:.:.....:.: ..::.:.:.|....:.:|...:...:|:..:.|
Human   186 KQLQERTGVKMVMIQDGPLPT-GADKPLRITGDAFKVQQAREMVLEIIREKDQAD---------- 239

  Fly   318 FPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAI 382
            |.|:.        |:   ||:.|...|.:                         :.:|..|||.:
Human   240 FRGVR--------GD---FNSRMGGGSIE-------------------------VSVPRFAVGIV 268

  Fly   383 IGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFE----KMREE 443
            ||..|..|:.|...:...::..|.|...|     ||...::|.|:....|.::|.|    ....:
Human   269 IGRNGEMIKKIQNDAGVRIQFKPDDGISP-----ERAAQVMGPPDRCQHAAHIISELILTAQERD 328

  Fly   444 GF--------------------MCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIK 488
            ||                    ..|..::..|    |.:.:.|.:|||||:|::.:.:.:|:.::
Human   329 GFGGLAAARGRGRGRGDWSVGAPGGVQEITYT----VPADKCGLVIGKGGENIKSINQQSGAHVE 389

  Fly   489 LPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSLA 553
            |..:  .||:.........|.|:...::.|::.|...:..||                      .
Human   390 LQRN--PPPNSDPNLRRFTIRGVPQQIEVARQLIDEKVGGTN----------------------L 430

  Fly   554 GAASSGSQQ--QQPQSPSQQQALPPQL---------------HHQPVSSASSSSTPPAH-HQQQA 600
            ||..:..|.  .||.:|..|...||:.               |..|||.      |||. .|...
Human   431 GAPGAFGQSPFSQPPAPPHQNTFPPRSSGCFPNMAAKVNGNPHSTPVSG------PPAFLTQGWG 489

  Fly   601 STAATSHQLQQQQPSPPPPGNATAAAAQQQQQLASSQ 637
            ||.....|..||.||             ||.|..|||
Human   490 STYQAWQQPTQQVPS-------------QQSQPQSSQ 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	16/69 (23%)
		RRM2_VICKZ	42..118	CDD:240805	7/25 (28%)
		KH-I	145..208	CDD:238053	23/82 (28%)
		KH-I	232..296	CDD:238053	13/63 (21%)
		KH-I	369..436	CDD:238053	17/66 (26%)
		KH-I	455..522	CDD:238053	16/66 (24%)
FUBP3	NP_003925.1	KH-I	78..148	CDD:412160	23/83 (28%)
		KH-I	159..241	CDD:412160	15/92 (16%)
		KH-I	252..321	CDD:412160	20/98 (20%)
		KH-I	356..424	CDD:412160	17/73 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..521		32/129 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840