DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Imp and HEN4

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001190612.1	Gene:	HEN4 / 836560	AraportID:	AT5G64390	Length:	866	Species:	Arabidopsis thaliana

Alignment Length:	725	Identity:	140/725 - (19%)
Similarity:	241/725 - (33%)	Gaps:	267/725 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VEFEGSKLHAEQLD---------KNQRRSQRNQRNPYPGMPGPGRQADFPLRILVQSEMVGAIIG 159
            :|....|.|||:..         .:.:|.:.:.......:..|...|.|  |:|.....|||:||
plant     1 MERNSVKFHAEKRSGAFDPGSGFGSSKRVKTHHTQLLSALVVPVGHAAF--RLLCPLSHVGAVIG 63

  Fly   160 RQGSTIRTITQQSRARVDVHRKENVGSLEKSITIY----------------GNPE---------- 198
            :.|:.|:.:.|.:.|::.|....: ||.::.|||.                ||.|
plant    64 KSGNVIKQLQQSTGAKIRVEEPPS-GSPDRVITIIAQADSKSRVKLGANNNGNAEGEKKEEEVEV 127

  Fly   199 -NCTNACKRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTK 262
             ....|..::.|::..||.|.         :.:| ::|..::..|.:|||.|..:..|.::|..|
plant   128 SKAQGALIKVFELLAAEADSD---------TVVC-RLLTESSHAGAVIGKGGQMVGSIRKETGCK 182

  Fly   263 ITVSSIN-------DINSFNLE-RIITVKGLIENMSRA------------------ENQISTKLR 301
            |::...|       |.....:| ..|.||..:.::||.                  |.:....|.
plant   183 ISIRIENLPICADTDDEMVEVEGNAIAVKKALVSISRCLQNCQSIDKVRMVGNRPLEKEFQASLH 247

  Fly   302 QSYENDLQAMAPQSL-------------MFP---------------------------------- 319
            :..|..:|...|:|:             :||
plant   248 RPIETIIQESLPRSVEVNPYDYRLRNDEIFPRGTVARANDVIPHDTLHLRRIEAVPQGALRMHIE 312

  Fly   320 ------------------------------------------------------GLH-PMAMMST 329
                                                                  .|| |..|:..
plant   313 ADRQDVLRRHVEADRQDALRRRIDVVPQETLYMPSDVLRGDCFRQHRERDDSHDSLHRPFEMVPR 377

  Fly   330 PGNGMVFNT----------------------------------SMPFPSCQSFAMSKTPASVVPP 360
            ...||.|.:                                  :.|.....|.:|:.| |::.||
plant   378 DAMGMPFESFPRDAYGRPIETMTQETLRGQSADYLAHRYSTLDTHPHSFTTSASMANT-ATMKPP 441

  Fly   361 VFPNDL----QETTY--LYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERK 419
              |:::    |:..:  |....|| |.:|||.|..:|.:...:.|.:.:.     ..||...||.
plant   442 --PSEVEVGNQDVVFKILCSTENA-GGVIGTGGKVVRMLHSETGAFINVG-----NTLDDCEERL 498

  Fly   420 VTIVGT--PEGQ----WKAQYMIFEKMREEGFMCGTDDV-------RLTVELLVASSQVGRIIGK 471
            :.:..:  ||.|    .||..:||.::    |...|:.:       .:|..|:|.:||:|.::||
plant   499 IAVTASENPECQSSPAQKAIMLIFSRL----FELATNKILDNGPRSSITARLVVPTSQIGCVLGK 559

  Fly   472 GGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSA----QRRIRAMMLSTNPP 532
            ||..|.|:::.||:.|::.:....|....:.:..|.|.|.|.:|:.|    ..|:|..:.|
plant   560 GGVIVSEMRKTTGAAIQILKVEQNPKCISENDQVVQITGEFPNVREAIFHITSRLRDSVFS---- 620

  Fly   533 PITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALPPQLHHQPVSSASSSSTPPAHHQ 597
                  .:.|..|.:...:|........|...|.|...         ||.||:.:::|: ..|.:
plant   621 ------NSMKNSLAKSSSALTTERFYDRQSDNPLSIGS---------HQSVSNPATNSS-SLHRR 669

  Fly   598 QQASTAATSH 607
            .:.|..:.||
plant   670 SEDSFLSGSH 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	9/50 (18%)
		RRM2_VICKZ	42..118	CDD:240805	5/22 (23%)
		KH-I	145..208	CDD:238053	21/89 (24%)
		KH-I	232..296	CDD:238053	19/89 (21%)
		KH-I	369..436	CDD:238053	19/74 (26%)
		KH-I	455..522	CDD:238053	22/70 (31%)
HEN4	NP_001190612.1	PCBP_like_KH	49..102	CDD:239089	18/55 (33%)
		PCBP_like_KH	151..218	CDD:239089	17/67 (25%)
		PCBP_like_KH	453..522	CDD:239089	19/74 (26%)
		PCBP_like_KH	543..611	CDD:239089	22/67 (33%)
		KH-I	786..849	CDD:238053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D286875at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3056
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920