DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and Pcbp4

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_067542.3	Gene:	Pcbp4 / 59092	MGIID:	1890471	Length:	403	Species:	Mus musculus

Alignment Length:	450	Identity:	112/450 - (24%)
Similarity:	184/450 - (40%)	Gaps:	91/450 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 GPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSL-EKSITIYGNPEN 199
            ||.......||:|:..:.||:|||::|.|::.|.:||.||:.:    :.||. |:..||.|:...
Mouse    11 GPELSITLTLRMLMHGKEVGSIIGKKGETVKRIREQSSARITI----SEGSCPERITTITGSTAA 71

  Fly   200 CTNACKRILEVMQQE--AISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTK 262
            ..:|...|...:.::  |...|.|.:|.  ..:.|:::...:..|.:|||:|..||.|.:.|..:
Mouse    72 VFHAVSMIAFKLDEDLCAAPANGGSVSR--PPVTLRLVIPASQCGSLIGKAGTKIKEIRETTGAQ 134

  Fly   263 ITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMM 327
            :.|:  .|:...:.||.:||.|:.:.:.....||...:.:|        .|:....| .||...:
Mouse   135 VQVA--GDLLPNSTERAVTVSGVPDAIILCVRQICAVILES--------PPKGATIP-YHPSLSL 188

  Fly   328 STPGNGMVFNTSMPFPSCQSFAMSKTPA------------------SVVPPVFPNDLQETTYLYI 374
            .|    ::.:.:..| |.|....:.|||                  ||||.:.|:....:....:
Mouse   189 GT----VLLSANQGF-SVQGQYGAVTPAEVTKLQQLSGHAVPFASPSVVPGLDPSTQTSSQEFLV 248

  Fly   375 PNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEK 439
            ||:.:|.:||.:||.|..|.:.|.|.:||.     ...:...||.|||.|:|.....|||:|
Mouse   249 PNDLIGCVIGRQGSKISEIRQMSGAHIKIG-----NQAEGAGERHVTITGSPVSIALAQYLI--- 305

  Fly   440 MREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEET 504
                           |..|..|.|..|...|....:             ||. ..:||.......
Mouse   306 ---------------TACLETAKSTSGGTPGSAPAD-------------LPT-PFSPPLTALPTA 341

  Fly   505 PVHIIGLFYSVQSAQ----RRIRAMML---STNPPP----ITKKQKAAKEQLQQQQQSLA 553
            |..::|..|::..:.    :.:..:.|   |..|||    .|.|..||....:.::|..:
Mouse   342 PPGLLGTPYAISLSNFIGLKPVPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFS 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	2/9 (22%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	22/63 (35%)
		KH-I	232..296	CDD:238053	17/63 (27%)
		KH-I	369..436	CDD:238053	23/66 (35%)
		KH-I	455..522	CDD:238053	13/70 (19%)
Pcbp4	NP_067542.3	PCBP_like_KH	19..80	CDD:239089	22/64 (34%)
		PCBP_like_KH	103..167	CDD:239089	18/65 (28%)
		KH-I	243..305	CDD:238053	23/66 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831599
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840