back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Imp and PCBP4

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_024309446.1	Gene:	PCBP4 / 57060	HGNCID:	8652	Length:	481	Species:	Homo sapiens

Alignment Length:	499	Identity:	110/499 - (22%)
Similarity:	181/499 - (36%)	Gaps:	152/499 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSL-EKSITIYGNPENCTNACKRIL 208
            ||:|:..:.||:|||::|.|::.|.:||.||:.:    :.||. |:..||.|:.....:|...|.
Human    43 LRMLMHGKEVGSIIGKKGETVKRIREQSSARITI----SEGSCPERITTITGSTAAVFHAVSMIA 103

  Fly   209 EVMQQE--AISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRI---------------- 255
            ..:.::  |...|.|.:|.  ..:.|:::...:..|.:|||:|..||.|
Human   104 FKLDEDLCAAPANGGNVSR--PPVTLRLVIPASQCGSLIGKAGTKIKEIREVRGEIYHPQGIRGK 166

  Fly   256 ---------------------------------------MQDTDTKITVSSINDINSFNLERIIT 281
                                                   :|.|..::.|:  .|:...:.||.:|
Human   167 GAVVRGVLGLWRPPHLESSEPGQPFSGLWEQPEVAPVLCLQTTGAQVQVA--GDLLPNSTERAVT 229

  Fly   282 VKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMVFNTSMPFPSCQ 346
            |.|:.:.:.....||...:.:|        .|:....| .||...:.|    ::.:.:..| |.|
Human   230 VSGVPDAIILCVRQICAVILES--------PPKGATIP-YHPSLSLGT----VLLSANQGF-SVQ 280

  Fly   347 SFAMSKTPA------------------SVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSI 393
            ....:.|||                  ||||.:.|.....:....:||:.:|.:||.:||.|..|
Human   281 GQYGAVTPAEVTKLQQLSSHAVPFATPSVVPGLDPGTQTSSQEFLVPNDLIGCVIGRQGSKISEI 345

  Fly   394 MRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVEL 458
            .:.|.|.:||.     ...:...||.|||.|:|.....|||:|                  |..|
Human   346 RQMSGAHIKIG-----NQAEGAGERHVTITGSPVSIALAQYLI------------------TACL 387

  Fly   459 LVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEH---ALAPPSGGDEETPVHIIGLFYSVQSAQ- 519
            ..|.|..|                 |:....|..   ..:||.......|..::|..|::..:.
Human   388 ETAKSTSG-----------------GTPSSAPADLPAPFSPPLTALPTAPPGLLGTPYAISLSNF 435

  Fly   520 ---RRIRAMML---STNPPP----ITKKQKAAKEQLQQQQQSLA 553
               :.:..:.|   |..|||    .|.|..||....:.::|..:
Human   436 IGLKPMPFLALPPASPGPPPGLAAYTAKMAAANGSKKAERQKFS 479

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.