Protein Alignment Imp and igf2bp1

DIOPT Version :9

• Sequence 1: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_001070027.2
• Gene: igf2bp1 / 558182
• ZFINID: ZDB-GENE-060929-1258
• Length: 598
• Species: Danio rerio
• Alignment Length: 578
• Identity: 219/578 - (37%)
• Similarity: 321/578 - (55%)
• Gaps: 98/578 - (16%)

  Fly    28 RQQLEGAGTSSVTTSKILISGIPMQTRFEDIEPLLKPYGIVKQCEAISSKDQNTQTVHITFENPE 92
            |.::|.:......|.|:.|..||...::|.::.||..||.|:.||.::: |..|..|::|:...|
Zfish    67 RIEVEHSVPKKQRTRKLQIRNIPPHLQWEVLDGLLAQYGTVENCEQVNT-DSETAVVNVTYGTRE 130

  Fly    93 QAQRAAVGLNGVEFEGSKLHAEQL-DKN-----QR------------RSQRNQRNPYPGMPGPGR 139
            ||::|...|||.:|:.:.|....: |:|     ||            |....|.:|..|:|...:
Zfish   131 QARQAIQKLNGYQFDNNALRVSYIPDENSEVDSQRGPDNGRRPGYGPRGTSRQMSPGSGIPSKHQ 195

  Fly   140 QADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCTNAC 204
            .||.|||:||.::.||||||::|:|||.||:|:::::|||||||.|:.||.|:|:..||.|:.||
Zfish   196 HADIPLRLLVPTQYVGAIIGKEGATIRNITKQTQSKIDVHRKENAGAAEKPISIHSTPEGCSAAC 260

  Fly   205 KRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSIN 269
            :.|||:|.|||..|...:      |:.||:|||||.:||:|||.|..:|::.||||||||:|.:.
Zfish   261 RMILEIMNQEAKDTKTAD------EVPLKVLAHNNFVGRLIGKEGRNLKKVEQDTDTKITISPLQ 319

  Fly   270 DINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLH--------PMAM 326
            |:..:|.||.|||||.||....||.:|..|:|::|:||:.||..|:.:.|||:        |.:.
Zfish   320 DLTLYNPERTITVKGSIEACCLAEQEIMKKVREAYDNDIAAMNQQTHLIPGLNLGAIGLFPPSSA 384

  Fly   327 MSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIR 391
            |..|..|    .|:|.|.......|:              |||.::|||..||||:||.:|.||:
Zfish   385 MPPPALG----NSVPGPPYGPMGASE--------------QETVHVYIPAQAVGALIGKKGQHIK 431

  Fly   392 SIMRFSNASLKIAPLDA-DKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLT 455
            .:.||:.||:||||.:| |..:     |.|.:.|.||.|:|||..|:.|::||.|....::|:|.
Zfish   432 QLSRFAGASIKIAPAEAPDSKM-----RMVIVTGPPEAQFKAQGRIYGKLKEENFFGPKEEVKLE 491

  Fly   456 VELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETP-------VHIIGLFY 513
            ..:.||::..||:|||||:.|.|||.:|.:.:.:|.          |:||       |.|||.||
Zfish   492 THIKVAAAAAGRVIGKGGKTVNELQNLTAAEVVVPR----------EQTPDEHDQVIVKIIGHFY 546

  Fly   514 SVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQ 571
            :.|.|||:||.::                .|::|||:        |.....||.|..|
Zfish   547 ASQLAQRKIRDIL----------------TQVKQQQK--------GGGMGTPQGPHPQ 580

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	38/126 (30%)
		RRM2_VICKZ	42..118	CDD:240805	25/76 (33%)
		KH-I	145..208	CDD:238053	34/62 (55%)
		KH-I	232..296	CDD:238053	36/63 (57%)
		KH-I	369..436	CDD:238053	32/67 (48%)
		KH-I	455..522	CDD:238053	28/73 (38%)
igf2bp1	NP_001070027.2	RRM1_IGF2BP1	1..77	CDD:241069	2/9 (22%)
		RRM	<2..>87	CDD:223796	5/19 (26%)
		RRM2_IGF2BP1	81..156	CDD:241072	25/75 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	155..195		9/39 (23%)
		KH-I	201..264	CDD:238053	34/62 (55%)
		KH-I	282..347	CDD:238053	36/64 (56%)
		KH-I	409..472	CDD:238053	32/67 (48%)
		KH	489..559	CDD:197652	31/79 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	561..598		9/28 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574661
Domainoid	1	1.000	85	1.000	Domainoid score	I8118
eggNOG	1	0.900	-	-		E1_KOG2193
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4772
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2190
OMA	1	1.010	-	-		QHG45563
OrthoDB	1	1.010	-	-		D286875at2759
OrthoFinder	1	1.000	-	-		FOG0001972
OrthoInspector	1	1.000	-	-		otm24525
orthoMCL	1	0.900	-	-		OOG6_103496
Panther	1	1.100	-	-	O	PTHR10288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.770