DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and igf2bp2b

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001082843.1	Gene:	igf2bp2b / 557028	ZFINID:	ZDB-GENE-060503-536	Length:	436	Species:	Danio rerio

Alignment Length:	482	Identity:	189/482 - (39%)
Similarity:	280/482 - (58%)	Gaps:	88/482 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 RNQRNPYPG-MPGP----GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENV 184
            |.|....|| |.||    .||.:.||||||.::.||||||::|.||:.||:|::::||:|||||.
Zfish     6 REQEFGQPGAMGGPQGPRQRQQELPLRILVPTQFVGAIIGKEGLTIKNITKQTQSKVDIHRKENA 70

  Fly   185 GSLEKSITIYGNPENCTNACKRILEVMQQEAISTNKGELSPECSEICLKILAHNNLIGRIIGKSG 249
            |:.||:|||:.:.|.|:.||:.|||:|::||..|...|      |:.|||||||:|:||:|||.|
Zfish    71 GATEKAITIHSSKEGCSQACRMILEIMEKEANDTKIVE------EVPLKILAHNSLVGRLIGKEG 129

  Fly   250 NTIKRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQ 314
            ..:|:|.|||.||||:|::.|:..:|.||.|:|:|.:|...:||.:|..|||:::|||:.::..|
Zfish   130 RNLKKIEQDTGTKITISALQDLTVYNQERTISVRGGVEECCKAEGEIMKKLREAHENDVASVNQQ 194

  Fly   315 SLMFPGLHPMAMMSTPGNGMVFNTSMP-FPSCQSFAMS-KTPASVVPPVFPNDL----------- 366
            :.|..||:    :|..|   :|::.|. .|.......| .|||:..|.:.|:.:
Zfish   195 TNMMAGLN----LSALG---IFSSGMSVLPPASGLRGSLSTPANYSPLLGPSIMGGLYGVPSSGA 252

  Fly   367 ---------QETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKI-APLDADKPLDQQTERKVT 421
                     ||..||:||..||||:||.:|.||:.:..|:.||:|| ||...|:|     ||.|.
Zfish   253 LSLQQAGGEQEVVYLFIPTPAVGALIGKKGQHIKELAHFAGASIKIAAPESPDEP-----ERMVI 312

  Fly   422 IVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSV 486
            |.|.||.|:|||..|:.|::||.|....::|:|...:.|.|:..||:|||||:.|.|||.:|.:.
Zfish   313 ITGPPEAQFKAQGRIYGKLKEENFFTAKEEVKLEAHIKVPSTAAGRVIGKGGKTVNELQNLTSAE 377

  Fly   487 IKLPEHALAPPSGGDEETP-------VHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQ 544
            :.:|.          ::||       |.|||.|::.|:|||:||.::                :|
Zfish   378 VIVPR----------DQTPDENDDVFVKIIGHFFASQTAQRKIREIV----------------QQ 416

  Fly   545 LQQQQQSLAGAASSGSQQQQPQSPSQQ 571
            ::||::         ..||.||:||:|
Zfish   417 VKQQER---------KHQQMPQTPSEQ 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	10/25 (40%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	34/62 (55%)
		KH-I	232..296	CDD:238053	34/63 (54%)
		KH-I	369..436	CDD:238053	33/67 (49%)
		KH-I	455..522	CDD:238053	26/73 (36%)
igf2bp2b	NP_001082843.1	KH-I	31..94	CDD:238053	34/62 (55%)
		KH-I	112..177	CDD:238053	34/64 (53%)
		arCOG04150	266..427	CDD:274711	72/200 (36%)
		PCBP_like_KH	267..327	CDD:239089	32/64 (50%)
		KH-I	346..410	CDD:238053	26/73 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574651
Domainoid	1	1.000	85	1.000	Domainoid score	I8118
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2190
OMA	1	1.010	-	-		QHG45563
OrthoDB	1	1.010	-	-		D286875at2759
OrthoFinder	1	1.000	-	-		FOG0001972
OrthoInspector	1	1.000	-	-		otm24525
orthoMCL	1	0.900	-	-		OOG6_103496
Panther	1	1.100	-	-	O	PTHR10288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910