DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Imp and nova1

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	NP_001038254.1	Gene:	nova1 / 555590	ZFINID:	ZDB-GENE-060526-113	Length:	495	Species:	Danio rerio

Alignment Length:	480	Identity:	116/480 - (24%)
Similarity:	187/480 - (38%)	Gaps:	120/480 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENV--GSLEKSITIYGNPENC 200
            |.:.::.|::|:.|...|:|||:.|.||..:.:::.|.:.:.:.::.  |:.|:...|.|..|..
Zfish    52 GEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLIQGTVEAL 116

  Fly   201 TNACKRILEVMQQEAISTNKGE----LSPECSE-----ICLKILAHNNLIGRIIGKSGNTIKRIM 256
            ......|.|.:::...|:.|.|    |.|:.:.     ...|::..|:..|.||||.|.|:|.:|
Zfish   117 NGVHNFIAEKVREMPQSSQKTEPVSILQPQTTVNPDRIKQAKLIVPNSTAGLIIGKGGATVKAVM 181

  Fly   257 QDTDTKITVSSINDINSFNL-ERIITVKGLIENMSRA----------ENQISTKLRQSYEN---- 306
            :.:...:.:|...:  ..|| ||::||.|..|...:|          :.|.|:.|..||.|
Zfish   182 EQSGAWVQLSQKPE--GINLQERVVTVSGEPEQNRKAVEIIVQKIQEDPQSSSCLNISYSNITGP 244

  Fly   307 -------------------DLQAMAPQSLMF-------PGLHPMAMMSTPGNGMV-----FNTSM 340
                               :..|.|..|.:.       .|..|.||.|..||.::     .||..
Zfish   245 VANSNPTGSPFANSTEVLPNAAAAATASTLLGQAGLAGMGGFPAAMSSLSGNDLLAITSALNTLA 309

  Fly   341 PF------------PSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSH--IR 391
            .:            |:..|..::...||..|..........||   .:.|.|.     |.|  ..
Zfish   310 SYGYNTNTLGLGLNPAAASGVLAAVAASANPAAAAAANLLATY---ASEASGG-----GGHPAAP 366

  Fly   392 SIMRFSNASLKIAP------LDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTD 450
            |:..||..||..|.      |:...||...     :::||            ||:.|.|
Zfish   367 SLGGFSLGSLAAATGASNGYLNPSSPLVAS-----SLLGT------------EKLAEGG------ 408

  Fly   451 DVRLTVELLVASSQVGRIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSV 515
              :..||:.|..:.||.|:||||:.:.|.|.:||:.|::.:.....|  |.....|.|.|...:.
Zfish   409 --KEVVEIAVPENLVGAILGKGGKTLVEYQELTGARIQISKKGEFIP--GTRNRKVTITGSPAAT 469

  Fly   516 QSAQRRIRAMML------STNPPPI 534
            |:||..|...:.      :|||..:
Zfish   470 QAAQYLISQRITYEQGVRATNPQKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	1/7 (14%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	16/64 (25%)
		KH-I	232..296	CDD:238053	21/74 (28%)
		KH-I	369..436	CDD:238053	17/74 (23%)
		KH-I	455..522	CDD:238053	23/66 (35%)
nova1	NP_001038254.1	PCBP_like_KH	58..124	CDD:239089	16/65 (25%)
		PCBP_like_KH	158..221	CDD:239089	21/64 (33%)
		KH-I	411..476	CDD:238053	23/66 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840