DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and pcbp3

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_021334343.1	Gene:	pcbp3 / 553765	ZFINID:	ZDB-GENE-050522-157	Length:	358	Species:	Danio rerio

Alignment Length:	361	Identity:	94/361 - (26%)
Similarity:	160/361 - (44%)	Gaps:	75/361 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 GRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSL-EKSITIYGNPENCT 201
            |......:|:|:..:.||:|||::|.|::.:.::|.||:::    :.|:. |:.:||.|..:...
Zfish    11 GLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINI----SEGNCPERIVTITGPTDAIF 71

  Fly   202 NACKRILEVMQQEAISTNKGELSPECSE--ICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKIT 264
            .|...|....:::.|  |....||..|:  :.|:::...:..|.:|||.|:.||.:.:.|..::.
Zfish    72 KAFAMIAYKFEEDII--NSMSNSPATSKPPVTLRLVVPASQCGSLIGKGGSKIKEMRESTGAQVQ 134

  Fly   265 VSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMST 329
            |:  .|:...:.||.:|:.|..|.:.:...||...:.:|        .|:....|  :.....||
Zfish   135 VA--GDMLPNSTERAVTISGTPEAIIQCVKQICVVMLES--------PPKGATIP--YRPKPAST 187

  Fly   330 P---GNGMV---------FNTSM-----PFPS---------------CQS----------FAMSK 352
            |   ..|.|         .|.|:     |.|:               |.|          .||.:
Zfish   188 PVIFSGGQVRADPLAASAANLSLLLQHQPLPAYTIQGQYAIPHPDLYCPSNPQQLTKLHQLAMQQ 252

  Fly   353 TPASVV---PPVFP----NDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNASLKIAPLDADK 410
            ||.:.:   .|.||    :....|..|.|||:.:|.|||.:|:.|..|.:.|.|.:|||     .
Zfish   253 TPFTPLGQTTPAFPGLDASPPASTHELTIPNDLIGCIIGRQGTKINEIRQMSGAQIKIA-----N 312

  Fly   411 PLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFM 446
            .::..:||::||.|||.....|||:|..:.|:...|
Zfish   313 AMEGSSERQITITGTPANISLAQYLINARFRDVAAM 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	1/7 (14%)
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	18/63 (29%)
		KH-I	232..296	CDD:238053	16/63 (25%)
		KH-I	369..436	CDD:238053	27/66 (41%)
		KH-I	455..522	CDD:238053
pcbp3	XP_021334343.1	PCBP_like_KH	17..78	CDD:239089	18/64 (28%)
		PCBP_like_KH	101..165	CDD:239089	17/65 (26%)
		G_path_suppress	<214..277	CDD:318248	11/62 (18%)
		KH_1	276..340	CDD:306517	28/68 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840