DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and PCBP3

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_024307854.1	Gene:	PCBP3 / 54039	HGNCID:	8651	Length:	596	Species:	Homo sapiens

Alignment Length:	477	Identity:	109/477 - (22%)
Similarity:	171/477 - (35%)	Gaps:	138/477 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 GRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGN----PENCTNACKRILEVMQQEAISTN 219
            |..||....:..:|....|.|.|.:.....::....|:    |           .|:....:||.
Human    29 GLSGSISSCLNGESGHLSDTHIKPDRSQPHRAALFQGDAFWAP-----------SVLPHSTLSTL 82

  Fly   220 KGELSPE--------CSE------ICLKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSIND 270
            .....|:        .||      :.:::|.|...:|.||||.|.|:|::.:::..:|.:|..|
Human    83 SHHPQPQFGRRMESKVSEGGLNVTLTIRLLMHGKEVGSIIGKKGETVKKMREESGARINISEGN- 146

  Fly   271 INSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMV 335
                ..|||:|:.|..:.:.:|...|:.|    :|.|                           :
Human   147 ----CPERIVTITGPTDAIFKAFAMIAYK----FEED---------------------------I 176

  Fly   336 FNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAIIGTRGSHIRSIMRFSNAS 400
            .|           :||.:||:..|||       |..|.:|.:..|::||..||.|:.|...:.|.
Human   177 IN-----------SMSNSPATSKPPV-------TLRLVVPASQCGSLIGKGGSKIKEIRESTGAQ 223

  Fly   401 LKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQV 465
            :::    |...|...|||.|||.|||:...:....|...|.|......|...|..    .||:.|
Human   224 VQV----AGDMLPNSTERAVTISGTPDAIIQCVKQICVVMLESPPKGATIPYRPK----PASTPV 280

  Fly   466 GRIIGKGGQNVR--ELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLS 528
               |..||| ||  .|...|.::..|.:|...|..|         :|          .|:|.:..
Human   281 ---IFAGGQ-VRADPLAASTANLSLLLQHPPLPKLG---------VG----------SIKAELFP 322

  Fly   529 TNPPPITKKQKAAKEQLQQQQQSLAGAASSGSQQQQPQSPSQQQALP--------PQLHHQPVSS 585
            ::|             |....| |.....||..|.:...||..:...        ||::.:..||
Human   323 SHP-------------LNWPAQ-LCPPRGSGPTQSRDSMPSLTRMCNSSAGGRSYPQINGRCNSS 373

  Fly   586 ASSSSTPPAHHQQQASTAATSH 607
            |...|.|..:.:..:|....|:
Human   374 AGGRSYPQINGRCNSSAGGRSY 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796
		RRM2_VICKZ	42..118	CDD:240805
		KH-I	145..208	CDD:238053	9/52 (17%)
		KH-I	232..296	CDD:238053	19/63 (30%)
		KH-I	369..436	CDD:238053	22/66 (33%)
		KH-I	455..522	CDD:238053	16/68 (24%)
PCBP3	XP_024307854.1	PCBP_like_KH	108..169	CDD:239089	19/65 (29%)
PCBP3	XP_024307854.1	PCBP_like_KH	192..256	CDD:239089	22/67 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141654
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840