Protein Alignment Imp and NOVA1

DIOPT Version :9

• Sequence 1: NP_001245616.1
• Gene: Imp / 32009
• FlyBaseID: FBgn0285926
• Length: 638
• Species: Drosophila melanogaster
• Sequence 2: NP_002506.2
• Gene: NOVA1 / 4857
• HGNCID: 7886
• Length: 507
• Species: Homo sapiens
• Alignment Length: 508
• Identity: 113/508 - (22%)
• Similarity: 184/508 - (36%)
• Gaps: 146/508 - (28%)

  Fly   116 LDKNQRRSQRNQRNPYPG---MPGPGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVD 177
            ||....|.:..:..|..|   ....|....:.|::|:.|...|:|||:.|.||..:.:::.|.:.
Human    20 LDPPDSRKRPLEAPPEAGSTKRTNTGEDGQYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIK 84

  Fly   178 VHRKENV------------GSLEKSITIYG----------------------NPENCTNACKRIL 208
            :.:.::.            |::|....::|                      .|:...|. .||.
Human    85 LSKSKDFYPGTTERVCLIQGTVEALNAVHGFIAEKIREMPQNVAKTEPVSILQPQTTVNP-DRIK 148

  Fly   209 EVMQQEAISTNKGELSPECSEIC--LKILAHNNLIGRIIGKSGNTIKRIMQDTDTKITVSSINDI 271
            :.:.....:|......|..:...  :||:..|:..|.||||.|.|:|.:|:.:...:.:|...|
Human   149 QTLPSSPTTTKSSPSDPMTTSRANQVKIIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPD- 212

  Fly   272 NSFNL-ERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLMFPGLHPMAMMSTPGNGMV 335
             ..|| ||::||.|..|...:|...|..|:::    |.|:.:..::.:..:......|.|.....
Human   213 -GINLQERVVTVSGEPEQNRKAVELIIQKIQE----DPQSGSCLNISYANVTGPVANSNPTGSPY 272

  Fly   336 FNTSMPFPSCQSFA----------MSKTPASVVPPVFPNDLQETT--------YLYIPNN----- 377
            .||:...|:..:.|          ::..|| |:.....|||...|        |.|..|.
Human   273 ANTAEVLPTAAAAAGLLGHANLAGVAAFPA-VLSGFTGNDLVAITSALNTLASYGYNLNTLGLGL 336

  Fly   378 ----AVGAII-------------------------------GTRGSHIRSIMRFSNASLKIAP-- 405
                |.||:.                               ||.|:       |:..||..|.
Human   337 SQAAATGALAAAAASANPAAAAANLLATYASEASASGSTAGGTAGT-------FALGSLAAATAA 394

  Fly   406 ----LDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMREEGFMCGTDDVRLTVELLVASSQVG 466
                ..|..||...     .|:||            ||..:     |:.||   ||:.|..:.||
Human   395 TNGYFGAASPLAAS-----AILGT------------EKSTD-----GSKDV---VEIAVPENLVG 434

  Fly   467 RIIGKGGQNVRELQRVTGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQ 519
            .|:||||:.:.|.|.:||:.|::.:.....|  |.....|.|.|...:.|:||
Human   435 AILGKGGKTLVEYQELTGARIQISKKGEFVP--GTRNRKVTITGTPAATQAAQ 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	6/32 (19%)
		RRM2_VICKZ	42..118	CDD:240805	1/1 (100%)
		KH-I	145..208	CDD:238053	17/96 (18%)
		KH-I	232..296	CDD:238053	23/64 (36%)
		KH-I	369..436	CDD:238053	20/120 (17%)
		KH-I	455..522	CDD:238053	23/65 (35%)
NOVA1	NP_002506.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		5/23 (22%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	27..43		2/15 (13%)
		PCBP_like_KH	51..117	CDD:239089	14/65 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	139..171		5/32 (16%)
		PCBP_like_KH	173..238	CDD:239089	23/66 (35%)
		KH-I	423..488	CDD:238053	24/68 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840