DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Imp and fubp1

DIOPT Version :9

Sequence 1:	NP_001245616.1	Gene:	Imp / 32009	FlyBaseID:	FBgn0285926	Length:	638	Species:	Drosophila melanogaster
Sequence 2:	XP_009295789.1	Gene:	fubp1 / 406418	ZFINID:	ZDB-GENE-040426-2159	Length:	662	Species:	Danio rerio

Alignment Length:	627	Identity:	132/627 - (21%)
Similarity:	216/627 - (34%)	Gaps:	188/627 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 FENPEQAQR---AAVGLNGVE---------FEGSKLHAEQLDKNQRRSQRNQRNPYP----GMPG 136
            |::..|..|   |.:|.:||.         :.|.|...|..|:.:.: :....:|:.    ||.|
Zfish    22 FKDALQRARQIAAKIGGDGVPPSPVSNDFGYGGQKRPLEDGDQPETK-KVPPSDPFSAVMGGMGG 85

  Fly   137 PGRQADFPLRILVQSEMVGAIIGRQGSTIRTITQQSRARVDVHRKENVGSLEKSITIYGNPENCT 201
            |.|......:  |...|||.||||.|..|..:.|:|..::.: ..::.|..::|:|:.|:|:...
Zfish    86 PPRSVSEEFK--VPDGMVGFIIGRGGEQISRLQQESGCKIQI-APDSGGMPDRSVTLTGSPDAIM 147

  Fly   202 NACKRILEVMQQEAISTNKGELSPECSEICLKILAHN--------------NLIGRIIGKSGNTI 252
            .|.:.:.|:::       ||..||        ...||              :..|.:|||.|.||
Zfish   148 TAKRLLSEIVE-------KGRPSP--------AFHHNDGPGMSVHEMMIPASKAGLVIGKGGETI 197

  Fly   253 KRIMQDTDTKITVSSINDINSFNLERIITVKGLIENMSRAENQISTKLRQSYENDLQAMAPQSLM 317
            |::.:....|:.:......|: ..::.:.:.|....:.:|::.:...:|.      |....|...
Zfish   198 KQLQERAGVKMVMIQDGPQNT-GADKPLRISGDPFKVQQAKDMVMDLIRD------QGFREQRGE 255

  Fly   318 FPGLHPMAMMSTPGNGMVFNTSMPFPSCQSFAMSKTPASVVPPVFPNDLQETTYLYIPNNAVGAI 382
            :.        |..|.|.....|:..|                              :|..|||.:
Zfish   256 YG--------SRAGGGGGGGESLDVP------------------------------VPRFAVGIV 282

  Fly   383 IGTRGSHIRSIMRFSNASLKIAPLDADKPLDQQTERKVTIVGTPEGQWKAQYMIFEKMR------ 441
            ||..|..|:.|...:...::..|.|...|     ||...|:|.|:....|..:|.:.:|
Zfish   283 IGRSGEMIKKIQNDTGVRIQFKPDDGSTP-----ERIAQIMGPPDRAQHAADIITDLLRSVQAGG 342

  Fly   442 ------------------------EEGFMCGTDDVRLTVELLVASSQVGRIIGKGGQNVRELQRV 482
                                    ..|...|..:...||..:    :.|.||||||:.::.:.:.
Zfish   343 PPGHGGGGGGGGGGRGRGRGQGNWNMGPPGGLQEFTFTVPTM----KTGLIIGKGGETIKNISQQ 403

  Fly   483 TGSVIKLPEHALAPPSGGDEETPVHIIGLFYSVQSAQRRIRAMMLSTNPPPITKKQKAAKEQLQQ 547
            :|:.|:|..:   ||...|.                  .|:...:..:|..|...::..:|::..
Zfish   404 SGARIELQRN---PPPNSDP------------------NIKIFTVRGSPQQIDYARQLVEEKIGG 447

  Fly   548 QQQSLA---------GAASSGSQQQQ-------PQSPSQQQALPPQLHHQPVSSASSSSTPPAHH 596
            ....:.         |..|.|....|       |.:|......||..|           .|||.:
Zfish   448 PVSPMGGPHGPPGPHGGPSHGPPGPQGPPAPMGPYNPGPYGQGPPGPH-----------GPPAPY 501

  Fly   597 QQQASTAATSHQLQQQQPSP---PPPGNATAAAA---QQQQQ 632
            |.|.......| .||.||.|   ....||.|.||   |.|||
Zfish   502 QPQGWGNGYPH-WQQGQPDPNKAAADANAAAWAAYYSQYQQQ 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Imp	NP_001245616.1	RRM	<37..>146	CDD:223796	17/73 (23%)
		RRM2_VICKZ	42..118	CDD:240805	10/41 (24%)
		KH-I	145..208	CDD:238053	18/62 (29%)
		KH-I	232..296	CDD:238053	14/77 (18%)
		KH-I	369..436	CDD:238053	18/66 (27%)
		KH-I	455..522	CDD:238053	15/66 (23%)
fubp1	XP_009295789.1	KH-I	91..153	CDD:238053	18/64 (28%)
		KH-I	176..241	CDD:238053	12/65 (18%)
		KH-I	269..331	CDD:238053	20/96 (21%)
		KH	378..445	CDD:197652	19/91 (21%)
		DUF1897	625..>640	CDD:286140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840